A5079355966- Neurological Disease Mechanisms and Treatments
- Alzheimer's disease research and treatments
- Neuroinflammation and Neurodegeneration Mechanisms
- Dementia and Cognitive Impairment Research
- Neurological Disorders and Treatments
- Amyotrophic Lateral Sclerosis Research
- Contact Dermatitis and Allergies
- Parkinson's Disease Mechanisms and Treatments
- Acute Ischemic Stroke Management
- Immune Response and Inflammation
- Genetic Neurodegenerative Diseases
- Myasthenia Gravis and Thymoma
- Mitochondrial Function and Pathology
- Peripheral Neuropathies and Disorders
- Neurogenetic and Muscular Disorders Research
- Allergic Rhinitis and Sensitization
- Intracranial Aneurysms: Treatment and Complications
- Neurological and metabolic disorders
- Stroke Rehabilitation and Recovery
- Vascular Malformations Diagnosis and Treatment
- Amyloidosis: Diagnosis, Treatment, Outcomes
- Free Radicals and Antioxidants
- Quinazolinone synthesis and applications
- Autoimmune Neurological Disorders and Treatments
- Intracerebral and Subarachnoid Hemorrhage Research
Okayama University
2015-2024
National Institute of Infectious Diseases
2001-2024
Okayama Medical Center
2014-2022
National Hospital Organization
2014-2022
Nitobe Memorial Nakano General Hospital
2011-2020
Kobe University
2018
Kitano Hospital
2017
National Institutes of Health
2015
Misato Junshin General Hospital
2012
Seirei Hamamatsu General Hospital
2012
Evodiamine, a major alkaloidal principle of Evodia fruits (Evodia rutaecarpa, Rutaceae), showed vanilloid receptor agonistic activities comparable to capsaicin. The Chinese literature refers as "hot nature" herb. In spite the similarities in actions evodiamine and capsaicin vitro, has no perceptible taste, including peppery hot taste. Therefore, effectiveness extract preventing obesity on male C3H mice, or SD rats were examined. When was supplemented at 0.03% diet fed mice for 12 days,...
Although chronic cerebral hypoperfusion (CCH) may affect Alzheimer's disease (AD) pathogenesis, the mechanism remains elusive. In present study, we investigated role of CCH on an AD mouse model in neurovascular unit, cerebrovascular remodeling, and trophic coupling. Moreover, examined protective effect galantamine. transgenic mice (APP23) were subjected to bilateral common carotid arteries stenosis with ameroid constrictors for slowly progressive hypoperfusion. exacerbated neuronal loss...
To compare the effectiveness of combination therapy with cholinesterase inhibitors (ChEI) plus memantine in all AD patients and older (age >75 years).The Okayama Memantine Study was used to clinical effects donepezil (n = 61) or galantamine 53) patients, separately, six batteries at baseline, 6 months ChEI only monotherapy, 3, 6, 12 after addition treatment schedule (18 total).The resulted stabilization Mini-Mental State Examination scores Hasegawa dementia rating for months, then...
Recently, aging societies have been showing an increasingly strong relationship between Alzheimer's disease (AD) and chronic cerebral hypoperfusion (HP). In the present study, we created a new mouse model for AD with HP, investigated its clinical pathological characteristics. di sease transgenic mice (APP23) were subjected to bilateral common carotid arteries stenosis ameroid constrictors slowly progressive HP. contrast simple APP23 mice, HP exacerbated motor cognitive dysfunctions white...
Abstract Oxidative stress is associated with the degeneration of both motor neurons and skeletal muscles in amyotrophic lateral sclerosis (ALS). A free radical scavenger edaravone has been proven as a therapeutic drug for ALS patients, but neuroprotective mechanism oxidative not fully investigated. In this study, we investigated model mice bearing sensor nuclear erythroid 2‐related factor 2 (Nrf2) G93A‐human Cu/Zn superoxide dismutase (Nrf2/G93A) treated by edaravone. vivo Nrf2 imaging...
Amyotrophic lateral sclerosis (ALS) is characterized by progressive loss of motor neurons. Multilineage-differentiating stress-enduring (Muse) cells are unique endogenous stem that show therapeutic effects on function in ALS mouse models. We conducted a single-center open phase II clinical trial to evaluate the safety and repeated intravenous injections an allogenic Muse cell-based product, CL2020, patients with ALS. Five received CL2020 intravenously once month for total six doses. The...
The protozoan parasite Entamoeba histolytica causes a wide spectrum of intestinal infections. In severe cases, the trophozoites can breach mucosal barrier, invade epithelium and travel via portal circulation to liver, where they cause hepatic abscesses, which prove fatal if left untreated. host Extra Cellular Matrix (ECM) plays crucial role in amoebic invasion by triggering an array cellular responses parasite, including induction actin rich adhesion structures. Similar protrusive...
The authors declare that they have no conflict of interest associated with this manuscript. Data S1. Supplementary methods. Please note: publisher is not responsible for the content or functionality any supporting information supplied by authors. Any queries (other than missing content) should be directed to corresponding author article.
Cardiotonic effects of evodiamine and rutaecarpine, constituents the fruits Evodia rutaecarpa Bentham Rutaceae, were evaluated on guinea pig isolated atria. Comparison with capsaicin, a vanilloid receptor agonist, revealed similar positive inotropic chronotropic activity, as judged from antagonistic competitive (capsaicin receptor) antagonist capsazepine, non-competitive ruthenium red, calcitonin gene related peptide CGRP(8-37), P2X purinoceptor PPADS, various desensitization studies....
Background and PurposeCognitive cerebrovascular diseases are common in the elderly, but differences plasma levels associations of biomarkers these remain elusive.Methods The present study investigated fatty acids [eicosapentaenoic acid (EPA) docosahexaenoic (DHA)], adiponectin, reptin, markers inflammation [high-sensitivity C-reactive protein (hsCRP) serum amyloid A (serum AA)], lipids [high-density lipoprotein low-density (LDL)] patients with Alzheimer's disease (AD) (n=266), mild cognitive...
Oxidative stress is part of the entire pathological process that underlies development Alzheimer’s disease (AD), including mild cognitive impairment (MCI) stage. Twendee X (TwX) a supplement containing strong antioxidative mix eight antioxidants, which has been shown to have clinical and therapeutic benefit in AD model mice. Here, we conducted multicenter, randomized, double-blind, placebo-controlled prospective interventional study evaluate efficacy TwX mitigating MCI. The primary outcomes...
Alzheimer’s disease (AD) is the most common dementia and a progressive neurodegenerative disorder aggravated by chronic hypoperfusion (HP). Since numerous evidence suggests that inflammation related with AD pathology, we investigated expression change of two anti-inflammatory markers, inter-alpha-trypsin inhibitor heavy chain H4 (ITIH4) alpha-2-HS-glycoprotein (AHSG), in novel model (APP23) HP at 12 month age. As compared wild type (WT, n = 10), immunohistochemical analysis showed higher...
Lymphocyte transformation tests with cobalt were done in 9 hard metal asthma patients diagnosed on the basis of a positive bronchial provocation test cobalt. Positive lymphocyte proliferation response to was defined statistically from results 18 controls comprising 12 metal-exposed and 6 non-exposed controls. Out 4 who had been reported have IgE antibody specific cobalt, lymphocytes 2 proliferated metal: one showed free other both cobalt-conjugated human serum albumin. These suggest that...
Sigma-1 receptor (Sig-1R) is expressed at endoplasmic reticulum (ER) membranes, where it regulates a variety of specific physiological functions. However, the profile and exact roles ER stress-related molecules after Sig-1R agonist treatment in an vivo stroke model are largely unknown. The aim this study to investigate effect novel agonist, aniline derivative compound (Comp-AD), on stress response following ischemic stroke. Male C57BL/6J mice received transient middle cerebral artery...
This study aimed to assess the risk of intracerebral hemorrhage (ICH) after tissue‐type plasminogen activator (tPA) treatment in rivaroxaban compared with warfarin‐pretreated male Wistar rat brain ischemia relation activation profiles protease‐activated receptor‐1, ‐2, ‐3, and ‐4 (PAR‐1, ‐4). After pretreatment warfarin (0.2 mg/kg/day), low‐dose (60 high‐dose (120 or vehicle for 14 days, transient middle cerebral artery occlusion was induced 90 min, followed by reperfusion tPA (10 mg/kg/10...