A5063636675- Hair Growth and Disorders
- melanin and skin pigmentation
- Wnt/β-catenin signaling in development and cancer
- Skin and Cellular Biology Research
- Amphibian and Reptile Biology
- T-cell and B-cell Immunology
- Nuclear Structure and Function
- Genomics and Phylogenetic Studies
- Atherosclerosis and Cardiovascular Diseases
- Identification and Quantification in Food
- Cancer and Skin Lesions
- Nerve injury and regeneration
- RNA Research and Splicing
- Mast cells and histamine
- RNA regulation and disease
National Institute of Biological Sciences, Beijing
2015-2021
Tsinghua University
2019
Lanzhou University
2014
Long-term adult stem cells sustain tissue regeneration throughout the lifetime of an organism. They were hypothesized to originate from embryonic progenitor that acquire long-term self-renewal ability and multipotency at end organogenesis. The process through which this is achieved often remains unclear. Here, we discovered hair follicle arise occupying a niche location defined by attenuated Wnt/β-catenin signaling. Hair initiation marked placode formation, depends on activation Soon...
Metabolites are major biological parameters sensed by many cell types in vivo, whether they function as signaling mediators of SC and niche cross talk to regulate tissue regeneration is largely unknown. We show here that deletion the Notch pathway co-factor RBP-J specifically mouse HFSCs triggers adjacent McSCs precociously differentiate their shared niche. Transcriptome screen vivo functional studies revealed elevated level retinoic acid (RA) caused de-repression RA metabolic process genes...
Male infertility and age-related reproductive decline remain major unmet medical challenges, with limited understanding of the underlying mechanisms. Here, we identify a stress granule-driven necroptosis pathway involving ZBP1 RIPK3 as central driver non-obstructive azoospermia (NOA), severe form male marked by loss spermatogenesis. We show that heat or environmental insults activate eIF2α kinases, inducing granules recruit to signaling complex. This leads activation, MLKL phosphorylation,...
The complete mitochondrial genome sequence of color changeable toad-headed agama, Phrynocephalus versicolor, was determined using polymerase chain reaction (PCR), long-and-accurate PCR and directly sequencing by primer walking. entire P. versicolor 16,429 bp in length, the accession KJ749841 content A, T, C, G were 36.1%, 26.5%, 24.9% 12.5%, respectively, which similar to most vertebrate. contain 13 protein-coding genes, 2 rRNA 23 tRNA plus one control region those other sand lizards gene...
Metabolite can regulate stem cell (SC) function in vitro and vivo. But very little is known about whether or not metabolites as signaling mediators of SC niche cross talk during tissue regeneration. The hair follicle cells (HFSCs) melanocyte (McSC) reside a shared collaborate the regeneration pigmented follicles. We show here that deletion Notch pathway co-factor RBP-J specifically mouse HFSCs triggers adjacent McSCs to precociously differentiate at beginning stage. Transcriptome screen...