About
Contact & Profiles
A5025418999
Research Areas
- Cholinesterase and Neurodegenerative Diseases
- Chemical synthesis and alkaloids
- Computational Drug Discovery Methods
- Chemical Synthesis and Reactions
- Oxidative Organic Chemistry Reactions
- Chemical Synthesis and Analysis
- Medicinal Plants and Neuroprotection
- Pesticide Exposure and Toxicity
University of Évora
2016-2018
10.1016/j.bioorg.2016.06.002
article
EN
Bioorganic Chemistry
2016-06-03
Abstract Based on the positive bioassay results of known oxindole hit compound rac ‐1‐benzyl‐3‐hydroxy‐3‐phenylindolin‐2‐one which showed significant inhibition butyrylcholinesterase (BuChE) (IC 50 =7.41 μM), a library 31 analogues 3‐substituted‐3‐hydroxyoxindoles was synthesized and screened for both acetylcholinesterase (AChE) BuChE activity. Our bioassays revealed that some new compounds exhibited moderate eel AChE ( Ee AChE) very good equine serum Eq BuChE) with best IC 1.02 μM. On basis...
10.1002/slct.201600932
article
EN
ChemistrySelect
2016-08-16
10.1016/j.bioorg.2016.05.004
article
EN
Bioorganic Chemistry
2016-05-14
10.1016/j.bmc.2018.12.007
article
EN
Bioorganic & Medicinal Chemistry
2018-12-10
We report an efficient methodology for the direct oxidative esterification of primary alcohols to diether-esters using pyridinium chlorochromate (PCC).
10.1039/c6ra07547a
article
EN
RSC Advances
2016-01-01
10.1002/chin.201647066
article
EN
ChemInform
2016-11-01
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