A5101518132- Aquaculture disease management and microbiota
- Animal Virus Infections Studies
- Topic Modeling
- Virus-based gene therapy research
- Virology and Viral Diseases
- Viral Infections and Vectors
- Rabies epidemiology and control
- interferon and immune responses
- Natural Language Processing Techniques
- Advanced Graph Neural Networks
- Music and Audio Processing
- Multimodal Machine Learning Applications
- Bacteriophages and microbial interactions
- Autophagy in Disease and Therapy
- Mosquito-borne diseases and control
- Data Quality and Management
- Viral Infections and Outbreaks Research
- Speech and dialogue systems
- Cancer, Hypoxia, and Metabolism
- Music Technology and Sound Studies
- CRISPR and Genetic Engineering
- MicroRNA in disease regulation
- Semantic Web and Ontologies
- Viral Infectious Diseases and Gene Expression in Insects
- Microbial infections and disease research
Chinese Academy of Fishery Sciences
2016-2025
Ministry of Agriculture and Rural Affairs
2019-2025
Hong Kong University of Science and Technology
2025
University of Hong Kong
2025
State Key Laboratory of Hydrology-Water Resources and Hydraulic Engineering
2025
Sichuan University
2021-2023
Ministry of Agriculture and Agro Based Industry
2022
Nankai University
2018-2021
Academy of Military Medical Sciences
2012-2014
Jilin University
2011-2013
Definitive embeddings remain a fundamental challenge of computational musicology for symbolic music in deep learning today. Analogous to natural language, can be modeled as sequence tokens. This motivates the majority existing solutions explore utilization word embedding models build embeddings. However, differs from languages two key aspects: (1) musical token is multi-faceted -- it comprises pitch, rhythm and dynamics information; (2) context two-dimensional each dependent on both melodic...
Grass carp reovirus (GCRV) is the causative agent of grass hemorrhage and causes significant loss fingerlings. However, little known about how virus distributed in organs tissues. The aim present study was to investigate distribution different GCRV stains tissues carp. pathogenicity tissue were monitored after intraperitoneal administration. showed a organs, particularly liver, spleen, kidney, intestine, muscle, which had higher number viral RNA copies during sixth ninth days. kidney highest...
The VP2 structural protein of parvovirus can produce virus-like particles (VLPs) by a self-assembly process in vitro, making VLPs attractive vaccine candidates. In this study, the canine (CPV) was expressed using baculovirus expression system and assembled into parvovirus-like insect cells pupae. Electron micrographs showed that they were very similar size morphology when compared to wild-type parvovirus. immunogenicity investigated mice dogs. Mice immunized intramuscularly with purified...
Largemouth bass (Micropterus salmoides) is an important and fast-growing aquaculture species in China. In 2017, epidemic associated with severe mortality occurred fingerlings of largemouth Guangdong, The causative pathogen was identified named as Birnavirus (LBBV) by virome analysis, viral isolation, electron microscopy, genome sequencing, Western blot, indirect immunofluorescence, experimental challenge, so on. Virome sequencing results showed that the relative abundance reads related to...
Lifting operations on construction sites, particularly for modular integrated (MiC), pose significant safety risks due to the large weight and size of modules. To enhance efficiency in MiC lifting, we develop an automated lifting monitoring algorithm pipeline using learning-based methods deploy it on-site. Our dataset includes 1,007 image-point cloud pairs from 37 liftings. We train advanced object detection models two-dimensional (2D) MiCs humans, integrating this with point data accurately...
Glutamine metabolism is essential for infectious spleen and kidney necrosis virus (ISKNV) replication. Glutaminase 1 (GLS1), the key enzyme of glutamine metabolism, c-Myc positively regulate ISKNV infection, while closely correlated with GLS1. However, regulatory mechanism among ISKNV, remains unclear. Here, we indicated that increased uptake by increasing GLS1, glutamate dehydrogenase (GDH) isocitrate (IDH2) expression metabolism. ORF102R, ORF093R ORF118L co-located in CPB cells. Co-IP...
The role of ferroptosis—a novel iron-dependent programmed cell death pathway—in infectious spleen and kidney necrosis virus (ISKNV) infection remains poorly understood. Here, we demonstrate that ISKNV induces ferroptosis in CPB cells. Following challenge, cells exhibited hallmark morphological alterations including mitochondrial shrinkage, increased membrane density, cristae reduction. Biochemical assays confirmed significant time-dependent elevations markers: malondialdehyde (MDA,...
Abstract The groundwater depth can affect the composition and structure of plant communities. However, effects on characteristics shrub–grass communities in muddy coastal zones remain uncertain. We conducted a field experiment to evaluate different depth, which included 0.54 m, 0.83 1.18 1.62 2.04 soil salinity, moisture, community diversity, distribution pattern growth dominant Tamarix chinensis zone Bohai Bay. Our results showed that (1) moisture salinity gradually decreased with...
Under oxidative stress, viruses prefer glycolysis as an ATP source, and glutamine is required anaplerotic substrate to replenish the TCA cycle. Infectious spleen kidney necrosis virus (ISKNV) induces reductive metabolism in host cells. Here we report that ISKNV infection increased NAD+/NADH ratio gene expression of glutaminase 1 (GLS1), glutamate dehydrogenase (GDH), isocitrate (IDH2) resulted phosphorylation activation mammalian target rapamycin (mTOR) CPB Inhibition mTOR signaling...
The disease caused by Largemouth bass ranavirus (LMBV) is one of the most severe viral diseases in largemouth (
Glucose is a main carbon and energy source for virus proliferation usually involved in the glycolysis, pentose phosphate pathway (PPP), tricarboxylic acid cycle (TCA cycle) pathways. In this study, we investigated roles of glucose-related metabolic pathways during replication infectious spleen kidney necrosis (ISKNV), which has caused serious economic losses cultured Chinese perch (Siniperca chuatsi) industry. We found that ISKNV infection enhanced PPP TCA at early stage glycolysis late...
Infectious spleen and kidney necrosis virus (ISKNV) has caused serious economic losses in the cultured mandarin fish (Siniperca chuatsi) industry China. Host metabolism alteration induced by disease infection may be core problem of pathogenesis. However, to date, little is known about disease-induced changes. In this study, we first reported ISKNV, virus, alteration. The metabolomics profiles Chinese perch brain cells (CPB) post-ISKNV at progressive time points were analyzed using...