A5034614757- Epilepsy research and treatment
- Pharmacological Effects and Toxicity Studies
- Shakespeare, Adaptation, and Literary Criticism
- Neuroscience and Neuropharmacology Research
- Fetal and Pediatric Neurological Disorders
- Genetics and Neurodevelopmental Disorders
- Hedgehog Signaling Pathway Studies
- Cerebrospinal fluid and hydrocephalus
- Medieval Literature and History
- Neonatal and fetal brain pathology
- Head and Neck Surgical Oncology
- Metabolism and Genetic Disorders
- Literature: history, themes, analysis
- Scottish History and National Identity
- Contemporary Literature and Criticism
- EEG and Brain-Computer Interfaces
- Advanced MRI Techniques and Applications
- Multiple Sclerosis Research Studies
- Poetry Analysis and Criticism
- Joseph Conrad and Literature
- Glioma Diagnosis and Treatment
- Shoulder Injury and Treatment
- Neurological disorders and treatments
- Diet and metabolism studies
- Folklore, Mythology, and Literature Studies
Centre Hospitalier Universitaire Sainte-Justine
2000-2024
Brown University
2024
University of California, Los Angeles
1991-2024
Université de Montréal
2024
Barrow Neurological Institute
2012-2023
Phoenix Children's Hospital
2013-2023
University of Arizona
2010-2023
University College London
2021
Harvard University
2021
The University of Melbourne
2021
Animal studies and sporadic case reports in human subjects have suggested that intermittent electrical stimulation of the anterior nucleus thalamus reduces seizure activity. We embarked on an open-label pilot study to determine initial safety tolerability bilateral (ANT), a range appropriate parameters, begin gather efficacy data.We report five patients (three men, two women; age range, 24-47 years), with follow-up between 6 36 months. All had intractable partial epilepsy. Four also...
The shoulder in swimming is subjected to multiple factors that can lead a high injury rate. To prevent injury, one must understand the biomechanics of swim ming. This paper describes electromyographic and cinematographic findings 12 muscles competitive swimmers without pain. re sults show three heads deltoid supraspinatus functioning synchrony place arm at hand entry exit, rhomboids upper trapezius position scapula for arm, pec toralis major latissimus dorsi propel body, subscapularis...
Summary: Purpose: To present the results of transcallosal surgical resection hypothalamic hamartoma (HH) in 26 patients with refractory epilepsy a prospective outcome study. Methods: Patients symptomatic to HH were referred for their (mean age, 10.0 years; range, 2.1–24.2 years). A transcallosal, interforniceal approach was used remove and/or disconnect hamartoma. Volumetry obtained on pre‐ and postoperative brain MRI scans determine percentage resection. Outcome assessment included...
<b><i>Objective:</i></b> To evaluate the safety and efficacy of oxcarbazepine (OXC) as adjunctive therapy in children with inadequately controlled partial seizures on one or two concomitant antiepileptic drugs (AEDs). <b><i>Background:</i></b> OXC has shown activity several comparative monotherapy trials newly diagnosed patients epilepsy, a placebo-controlled trial hospitalized evaluated for epilepsy surgery. <b><i>Design:</i></b> A total 267 were multicenter, randomized, consisting three...
The purpose of this paper is to describe the patterns activity 12 shoulder muscles in painful shoulders, and compare those with normal shoulders. results show significant differences 7 muscles. Those included anterior deltoid, middle infraspinatus, subscapularis, up per trapezius, rhomboids, serratus anterior. There were no between muscle versus shoulders latissimus dorsi, pectoralis major, teres minor, su praspinatus, or posterior deltoid. This information will contribute development...
Journal Article John Kerrigan. Revenge Tragedy: Aeschylus to Armageddon. Get access By Oxford: Clarendon Press, 1996. Pp. xvi + 404. $75.00 cloth. Linda Charnes Search for other works by this author on: Oxford Academic Google Scholar Shakespeare Quarterly, Volume 48, Issue 4, Winter 1997, Pages 501–505, https://doi.org/10.2307/2871273 Published: 01 December 1997
Hypothalamic hamartomas (HHs), rare developmental abnormalities of the inferior hypothalamus, often cause refractory, symptomatic, mixed epilepsy, including gelastic seizures. We present 37 patients with HH who underwent transcortical transventricular endoscopic resection.Between October 2003 and April 2005, 42 consecutive refractory epilepsy resection were studied prospectively. The endoscope was held by an articulated pneumatic arm tracked a frameless stereotactic neuronavigation system....
Preface List of illustrations 1. Introduction 2. Archipelagic Macbeth 3. The Romans in Britain: Wales and Jacobean Drama 4. William Drummond the British Problem 5. Religion Caroline Ireland 6. God Wales: Morgan Llwyd, Henry Vaughan, Katherine Philips 7. Archipelago Enlarged: Milton Marvell to 1660 8. Orrery's 9. Our Scotland: Marvell, Mackenzie, Cleland 10. Derry School 11. Defoe, Scotland, Union 12. Epilogue: 1707 All That Primary Sources
Hypothalamic hamartomas present with isolated fits of ictal laughter (gelastic epilepsy) or a combination gelastic and other types seizures. Many these patients also suffer from cognitive decline, neuropsychiatric comorbidities precocious puberty. Although there is large body anecdotal evidence about hypothalamic seizures, many questions still remain to be answered. For instance, which specific regions are most affected by the location causing laughing versus seizures? Does neuroanatomical...
The significance of rhythmic and periodic EEG patterns in critically ill patients is unclear. A universal terminology needed to facilitate study these patterns, consistent observer agreement should be demonstrated its use. authors evaluated inter- intraobserver using the standardized (Hirsch et al., J Clin Neurophysiol 2005;22:128-135) recently proposed by American Clinical Neurophysiology Society. Trained electroencephalographers viewed a series 10-second samples from adults (phase I), set...
This study aimed at identifying outcomes with respect to seizures, morbidity, and mortality in adult patients undergoing resective or Gamma Knife surgery (GKS) treat intractable epilepsy associated hypothalamic hamartoma (HH).Adult surgical treatment for HH-related were prospectively monitored a single center complications seizure outcome by using proprietary database. Preintervention postintervention data 18 years of age older, least 1 year follow-up, analyzed, specific attention control,...
Summary Hypothalamic hamartomas ( HH s) are congenital malformations of the ventral hypothalamus resulting in treatment‐resistant epilepsy and intrinsically epileptogenic for gelastic seizures that hallmark symptom this disorder. This paper reviews neuropathologic features s associated with epilepsy, an emphasis on characterizing neuron phenotypes ultimate goal understanding cellular model ictogenesis occurring locally within tissue. We also present previously unpublished findings Golgi...
Summary Objective The purpose of this study is to investigate the outcomes epilepsy surgery targeting subcentimeter‐sized resting state functional magnetic resonance imaging (rs‐fMRI) epileptogenic onset zone (EZ) in hypothalamic hamartoma (HH). Methods Fifty‐one children with HH ‐related intractable received anatomical MRI ‐guided stereotactic laser ablation (SLA) procedures. Fifteen these were control subjects ( CS ) not guided by rs‐ fMRI . Thirty‐six had been preoperatively RS determine...
Postoperative resting-state functional magnetic resonance imaging (MRI) in children with intractable epilepsy has not been quantified relation to seizure outcome. Therefore, its value as a biomarker for epileptogenic pathology is well understood. In sample of who underwent prospective onset zone (SOZ)-targeted surgery, postoperative MRI (rs-fMRI) was performed 6 12 months later. Graded normalization the SOZ compared outcomes, patient, and anatomical characteristics. A total 64 cases were...
Hypothalamic hamartomas (HHs) are rare developmental tumors that cause seizures or pituitary axis dysfunction, usually beginning in childhood. We analyzed HH tissue from 57 patients whose were resected through recently developed transcallosal interforniceal and transventricular endoscopic surgical approaches. All cases composed of abnormally distributed but cytologically normal neurons glia, including fibrillary astrocytes oligodendrocytes. Neuronal elements predominated most cases, a...