A5015679486- Neurobiology and Insect Physiology Research
- Ion channel regulation and function
- Nicotinic Acetylcholine Receptors Study
- Plant and Biological Electrophysiology Studies
- Plant Molecular Biology Research
- Receptor Mechanisms and Signaling
- Cellular transport and secretion
University of Calgary
2014-2020
Alberta Children's Hospital
2020
Neurotrophic factors (NTFs) support neuronal survival, differentiation, and even synaptic plasticity both during development throughout the life of an organism. However, their precise roles in central synapse formation remain unknown. Previously, we demonstrated that excitatory Lymnaea stagnalis requires a source extrinsic NTFs receptor tyrosine kinase (RTK) activation. Here show such as epidermal growth factor (L-EGF) act through RTKs to trigger specific subset intracellular signalling...
Abstract Synapse formation and plasticity depend on nuclear transcription site-specific protein targeting, but the molecular mechanisms that coordinate these steps have not been well defined. The MEN1 tumor suppressor gene, which encodes menin, is known to induce synapse in CNS. This synaptogenic function has conserved across evolution, however underlying remain unidentified. Here, using central neurons from invertebrate Lymnaea stagnalis , we demonstrate menin coordinates subunit-specific...
The mechanism of postsynaptic neurotransmitter receptor clustering has been best described at the neuromuscular junction (NMJ), where packets nicotinic acetylcholine receptors (nAChRs) in muscle fibre are redistributed to synaptic site upon motor neuron innervation. This process localisation is facilitated by agrin signalling, and stability resulting nAChR clusters depends activation Src family kinases (SFKs). In contrast NMJ however, cellular signalling mechanisms orchestrating nAChRs...