A5087945170- Infant Nutrition and Health
- Neonatal Respiratory Health Research
- Microbial metabolism and enzyme function
- Birth, Development, and Health
- Digestive system and related health
- Porphyrin Metabolism and Disorders
- Per- and polyfluoroalkyl substances research
- Immune responses and vaccinations
- Clinical Nutrition and Gastroenterology
- Preterm Birth and Chorioamnionitis
- Immune Cell Function and Interaction
- Macrophage Migration Inhibitory Factor
Yale University
2023-2025
Pediatrics and Genetics
2024
Extremely premature infants (EPIs) who are born before 30 weeks of gestation susceptible to infection; however, the trajectory their peripheral immunity is poorly understood. Here, we undertook longitudinal analyses immune cells from 250 μl whole blood at 1 week, month, and 2 months 10 EPIs compared these with samples healthy adults preterm full-term cord samples. Single-cell suspensions individual were split perform single-cell RNA sequencing, T B cell receptor phosphoprotein mass...
Preeclampsia (PEC) is a complication of pregnancy associated with hypertension and the risk eclampsia. The pathophysiology PEC unknown identifying factors during crucial for placental, fetal, maternal health. Renalase (RNLS) an anti-inflammatory secretory flavoprotein hypertension. Recent data demonstrated correlation between serum RNLS PEC, work from our group identified expression in placenta. However, it remains whether levels placenta are altered by preeclampsia. Additionally, unclear if...
Pregnancies rely upon the balance between fetal and maternal immune systems. Employing imaging mass cytometry, this study creates a spatial map landscape to unravel cellular dynamics within placental villi (PV). Consistent with previous data we report structural remodeling in PV, highlighted by increased syncytial trophoblasts, vascular smooth muscle cells, endothelial cells term PV. Additionally, identified that rare populations including dendritic innate lymphoid myeloid-derived suppressor...
Preeclampsia (PEC) is a complication of pregnancy associated with hypertension and the risk eclampsia. The pathophysiology PEC unknown identifying factors during crucial for placental, fetal, maternal health. Renalase (RNLS) an anti-inflammatory secretory flavoprotein hypertension. Recent data demonstrated correlation between serum RNLS PEC, work from our group identified expression in placenta. However, it remains whether levels placenta are altered by preeclampsia. Additionally, unclear if...
Introduction Spontaneous intestinal perforation (SIP) is a poorly understood severe gastrointestinal complications of prematurity which understood. Extremely premature infants born prior to 28 weeks’ gestation develop localized the terminal ileum during first week life and therapy involves surgery cessation enteral feeds. Little known regardj g impact mucosal immune dysfunction on disease pathogenesis. Methods We performed mass cytometry time flight (CyTOF) small mucosa patients with SIP...