A5005662131- Phytochemistry and Biological Activities
- Essential Oils and Antimicrobial Activity
- Phytochemicals and Antioxidant Activities
- Diabetes and associated disorders
- T-cell and B-cell Immunology
- Immune Cell Function and Interaction
- Insect Pest Control Strategies
- Heavy Metals in Plants
- Plant Toxicity and Pharmacological Properties
- Kidney Stones and Urolithiasis Treatments
- Biological Activity of Diterpenoids and Biflavonoids
- Bee Products Chemical Analysis
- Silymarin and Mushroom Poisoning
- Insect Utilization and Effects
- Protein Degradation and Inhibitors
- Tannin, Tannase and Anticancer Activities
- Nanoparticles: synthesis and applications
- Moringa oleifera research and applications
- Plant biochemistry and biosynthesis
- Biochemical and Molecular Research
- Proteins in Food Systems
- Aquaculture Nutrition and Growth
- Food composition and properties
- Ethnobotanical and Medicinal Plants Studies
- Seaweed-derived Bioactive Compounds
Institut Cochin
2020-2024
Centre National de la Recherche Scientifique
2020-2024
Centre National de Recherche en Génomique Humaine
2024
Université Paris Cité
2020
Inserm
2020
Anchusa italica Retz has been used for a long time in phytotherapy. The aim of the present study was to determine antioxidant and antibacterial activities extracts from leaves roots Retz. We first determined content phenolic compounds flavonoids using Folin-Ciocalteu reagents aluminum chloride (AlCl3). activity three methods: reducing power (FRAP), 2.2-diphenyl-1-picrylhydrazyl (DPPH), total capacity (TAC). antimicrobial investigated against four strains Escherichia coli, two Klebsiella...
Introduction Finding natural sources of bioactive compounds is turning into a cutting- edge task for the scientific community and industry alike. Abies marocana , Moroccan fir, holds great importance due to its ecological, economic, social, cultural significance. Material Methods The current study aimed evaluate needles in terms nutritional anti-nutrient content, components, antioxidant capacity. AOAC technique was used determine composition needles. Mineral content analyzed by inductively...
The antigenic peptides processed by β-cells and presented through surface HLA class I molecules are poorly characterized. Each variant (e.g., the most common being HLA-A2 HLA-A3) carries some peptide-binding specificity. Hence, features that, despite these specificities, remain shared across variants may reveal factors favoring β-cell immunogenicity. Building on our previous description of HLA-A2/A3 peptidome β-cells, we analyzed HLA-A3-restricted targeted circulating CD8+ T cells. Several...
Introduction Morocco is renowned for its rich plant biodiversity, although many plants are underutilized. Consequently, the present study was conducted to assess nutritional composition, bioactive constituents, antioxidant properties, and acute oral toxicity of Abies marocana's woody biomass. Methods The value twigs cones determined using AOAC method, while mineral components were examined through ICP-OES. To search phytochemicals in methanolic extracts, a number established techniques...
Mentha pulegium L., (MP) of the Lamiaceae family, endemic to Morocco, is a medicinal plant used in classical medicine. The aim present study enhance value this species by investigating chemical composition its essential oil (EO), antioxidant activity, toxicity, molecular docking and antimicrobial properties. In vitro measurement activity using 2,2-diphenyl-1-picrylhydrazyl radical (DPPH) reduction assay 2,2′-azino-bis (3-ethylbenzothiazoline-6-sulphonic acid; ABTS) demonstrated plant’s best...
Introduction Milk thistle ( Silybum marianum L.) is a wild plant commonly employed in traditional medicine, particularly for its recognized applications treating liver diseases. However, there are limited data available on the phytochemical analysis and biological activity of different parts milk cultivated Morocco. Material methods This study aims to examine compare composition, antioxidant antibacterial seeds, leaves stems thistle. The has been carried out using 2,2-diphenyl-1-...
The plant Saussurea costus (Falc) Lipsch has many biological activities and a strong curative preventive power against variety of diseases including cancer, diabetes, hemorrhoids. In the current study, phytochemical screening was carried out as well an investigation antilithiatic antioxidant aqueous ethanolic extracts this plant. results showed that were effective in reducing cystine stone mass extract had highest percentage dissolution (6.756 ± 1.024) (p < 0.05). A turbidimetric method...
In recent years, there has been a focus on developing and discovering novel Bruton's tyrosine kinase (BTK) inhibitors, as they offer an effective treatment strategy for B-cell malignancies. BTK plays crucial role in B cell receptor (BCR)-mediated activation proliferation by regulating downstream factors such the NF-κB MAP pathways. To address this challenge propose potential therapeutic options lymphomas, researchers conducted 2D-QSAR ADMET studies pyrrolopyrimidine derivatives that act...
The extraction of gum from natural raw materials is increasing importance in various industries, including food, pharmaceuticals, and cosmetics, particularly due to their emulsifying properties potential applications as stabilizers thickeners. This study presents an insight on the influence changing parameters like reagents operating condition yield some flax ( Linum usitatissimum L.) seed gum. conditions were meticulously examined using a full factorial design, highlighting significant...
The present study was conducted to evaluate the acute toxicity and anti-inflammatory effect in vivo, as well antioxidant activity, of essential oil Thymus leptobotrys Murb. results indicate that tested is non-toxic, with an estimated LD50 2500 mg kg-1 mice body weight. test revealed that, at a dose 200 kg-1, reduced rat paw edemas by 89.59% within 3 h oral administration, this reduction edema size greater than obtained indomethacin (75.78%). activity (IC50) Murb 346.896 µg mL-1 861.136...
Phytotherapy, which involves the use of plant extracts and natural compounds for medicinal purposes, is indeed a promising alternative managing urinary lithiasis. Many plants have been studied their potential to prevent treat kidney stones, they may offer more potentially less harmful approach compared conventional treatments. Additionally, phytotherapy be cost-effective. The aim present study was investigate antilithic essential oils
Abstract This article aimed to study the antimicrobial activity, chemical composition, and acute oral toxicity of essential oils (EOs) Mentha pulegium Rosmarinus officinalis , two aromatic medicinal plants widely used in traditional Moroccan pharmacopeia. The average content EOs was 3.2 2.5% for M. R. respectively. characterization showed a richness some compounds identified by gas chromatography coupled with mass spectrometry (GC/MS): R (+)-Pulegone (45.48%), Menthone (14.2%), Piperitone...
Abstract This study aims to contribute the valorizing of aromatic and medicinal plants Morocco by studying antioxidant antifungal properties essential oils (EOs) Allium sativum (AS) (garlic) Urginea maritima (Syn. Drimia ) tested in vitro . After hydrodistillation EOs, we determined their physicochemical indices according an international standard (Moroccan ISO standard), chemical composition was studied gas chromatography coupled with mass spectrometry (GC-MS). Then, were using free radical...
Snail flesh is a highly nutritious and easily digestible food commonly integrated into the human diet. In this study, snails belonging to
Introduction In the global field of nanotechnology, production silver nanoparticles (AgNPs) is an environmentally beneficial technique. To prevent diseases caused by many commonly used pesticides, it essential to synthesize safe alternatives from low-cost sources. Material and methods This study focuses on eco-friendly extracellular AgNPs using aqueous extract Ulva lactuca as a reducing agent in nitrate solution. The biosynthetic reaction was confirmed through various analytical techniques,...
The antigenic peptides processed by β cells and presented through surface HLA Class I molecules are poorly characterized. Each variant, e.g. the most common HLA-A2 HLA-A3, carries some peptide-binding specificity. Hence, features that, despite these specificities, remain shared across variants may reveal factors favoring β-cell immunogenicity. Building on our previous description of HLA-A2/A3 peptidome cells, we analyzed HLA-A3-restricted targeted circulating CD8<sup>+</sup> T...
The antigenic peptides processed by β cells and presented through surface HLA Class I molecules are poorly characterized. Each variant, e.g. the most common HLA-A2 HLA-A3, carries some peptide-binding specificity. Hence, features that, despite these specificities, remain shared across variants may reveal factors favoring β-cell immunogenicity. Building on our previous description of HLA-A2/A3 peptidome cells, we analyzed HLA-A3-restricted targeted circulating CD8<sup>+</sup> T...