A5086549540- Immunotherapy and Immune Responses
- Cervical Cancer and HPV Research
- Cancer Immunotherapy and Biomarkers
- Hepatitis B Virus Studies
- Immune Cell Function and Interaction
- Genital Health and Disease
- Immune Response and Inflammation
- Virus-based gene therapy research
- CAR-T cell therapy research
- Liver Disease Diagnosis and Treatment
- Sperm and Testicular Function
- Reproductive Biology and Fertility
- vaccines and immunoinformatics approaches
- Mast cells and histamine
- Endometriosis Research and Treatment
- Mental Health Research Topics
- Urban Transport Systems Analysis
- Advanced NMR Techniques and Applications
- Nuclear Receptors and Signaling
- Cancer-related molecular mechanisms research
- Rheumatoid Arthritis Research and Therapies
- Technology Assessment and Management
- Pluripotent Stem Cells Research
- Nanoparticle-Based Drug Delivery
- Lanthanide and Transition Metal Complexes
Tongren Hospital
2024-2025
Shanghai Jiao Tong University
2025
Third Affiliated Hospital of Southern Medical University
2024
Shanghai Tenth People's Hospital
2014-2017
Tongji University
2014-2017
Johns Hopkins University
2014-2015
Fudan University
2014-2015
Shanghai Institute of Planned Parenthood Research
2005-2015
Tianjin People's Hospital
2015
Xiaomi (China)
2012
Two viral oncoproteins, E6 and E7, are expressed in all human papillomavirus (HPV)-infected cells, from initial infection the genital tract to metastatic cervical cancer. Intramuscular vaccination of women with high-grade intraepithelial neoplasia (CIN2/3) twice a naked DNA vaccine, pNGVL4a-sig/E7(detox)/HSP70, single boost HPVE6/E7 recombinant vaccinia vaccine (TA-HPV) elicited systemic HPV-specific CD8 T-cell responses that could traffic lesion was associated regression some patients...
Imiquimod is a Toll-like receptor 7 agonist used topically to treat external genital warts and basal cell carcinoma. We examined the combination of topical imiquimod with intramuscular administration CRT/E7, therapeutic human papillomavirus (HPV) vaccine comprised naked DNA vector expressing calreticulin fused HPV16 E7.
Abstract Objective The aim was to develop and validate a nomogram for evaluating the risk of fatigue in climacteric women assess its clinical application value. Methods Clinical information collected from 402 who visited tertiary hospital Shanghai between November 2023 April 2024. Network analysis methods were utilized analyze core symptom (fatigue). study participants then randomly divided into training validation cohorts 7:3 ratio. Univariate multivariate logistic regression analyses...
Human papillomavirus (HPV) infections are particularly problematic for HIV + and solid organ transplant patients with compromised CD4+ T cell-dependent immunity as they produce more severe progressive disease compared to healthy individuals. There no specific treatments chronic HPV infection, resulting in an urgent unmet need a modality that is safe effective both immunocompromised otherwise normal recalcitrant disease. DNA vaccination attractive because it avoids the risks of administration...
CD40 and ligand (CD40L) are costimulatory molecules that play a pivotal role in the proinflammatory immune response. Primarily expressed by activated CD4+ T cells, CD40L binds to on antigen presenting cells (APCs), thereby inducing APC activation. APCs, turn, prime cytotoxic lymphocytes (CTLs). Here, two tumor-associated (TAA) animal models, p53-based GP100-based, were utilized examine ability of CD40-CD40L improve antigen-specific CTL-mediated antitumor responses. Although p53 GP100...
An improved understanding of the pluripotency maintenance embryonic stem (ES) cells is important for investigations early embryo development and cell replacement therapy, but mechanism behind still incompletely understood. Recent findings show that zinc, an essential trace element in humans, critically involved regulating various signaling pathways genes expression. However, its role ES fate determination remains to be further explored. Here we showed 2μM zinc chloride (ZnCl2) transiently...
Ino80 ATPase is an integral component of the INO80 ATP-dependent chromatin-remodeling complex, which regulates transcription, DNA repair and replication. We found that was highly expressed in cervical cancer cell lines tumor samples. knockdown inhibited proliferation, induced G0/G1 phase cycle arrest vitro suppressed growth vivo. However, did not affect apoptosis, migration or invasion vitro. overexpression promoted proliferation H8 immortalized epithelial line, has low endogenous expression...
Chemotherapy and/or radiation therapy are widely used as cancer treatments, but the antitumor effects they produce can be enhanced when combined with immunotherapies. kills tumor cells, it also releases antigen and allows cross-presentation of to trigger antigen-specific cell-mediated immune responses. Promoting CD4+ T helper cell responses enhance following chemotherapy. The pan HLA-DR binding epitope (PADRE peptide) is capable generating cells that bind various MHC class II molecules high...
Background: Axial spondyloarthritis (axSpA) is frequently diagnosed late, particularly in human leukocyte antigen (HLA)-B27-negative patients, resulting a missed opportunity for optimal treatment. This study aimed to develop an artificial intelligence (AI) tool, termed NegSpA-AI, using sacroiliac joint (SIJ) magnetic resonance imaging (MRI) and clinical SpA features improve the diagnosis of axSpA HLA-B27-negative patients. Methods: We retrospectively included 454 patients with...
To explore the biological characteristics of recombinant zona pellucida 3 (ZP3) peptides rhuZP3a22 approximately 176 and rhuZP3b177 348, we examined whether or 348 trigger acrosome reaction (AR) human spermatozoa investigated underlying mechanism. The assessment AR was performed using chlortetracycline staining. intracellular free calcium concentration ([Ca2+]i) in Fura-2/AM-loaded sperm monitored with a spectrofluorophotometer. We found that were capable eliciting at different...
Objective In this study, we collected perioperative and postoperative follow-up data from patients with endometrial cancer (EC) at different stages to evaluate the role of sentinel lymph node biopsy (SLNB) in surgery. Methods A total 186 undergoing radical hysterectomy January 2018 April 2022 were retrospectively analyzed. Patients classified into four groups. Group comprised diagnosed stage IA grade 1 2 endometrioid EC who underwent SLNB. B did not undergo C higher-grade EC, wherein...
<div>Abstract<p><b>Purpose:</b> Imiquimod is a Toll-like receptor 7 agonist used topically to treat external genital warts and basal cell carcinoma. We examined the combination of topical imiquimod with intramuscular administration CRT/E7, therapeutic human papillomavirus (HPV) vaccine comprised naked DNA vector expressing calreticulin fused HPV16 E7.</p><p><b>Experimental Design:</b> Using an orthotopic E6/E7<sup>+</sup> syngeneic...
<p>Comparison of anti-tumor effect generated by either pNGVL4a-Sig/E7(detox)/HSP70 intracervicovaginal vaccination followed TA-HPV boost or vaccination</p>
<p>Supplementary Figure Legends</p>
<p>Local and systemic immune responses produced by different vaccination routes</p>
<p>Characterization of MAdCAM-1 expression in cervicovaginal tissue after vaccination</p>
<p>Migration of CSFE-labeled α4β7 expressing E7-specific CD8+ T cells into spleen and vagina WT or Itgb7-/- mice</p>
<p>Comparison of HPV16 E7-specific CD8+ T cells induced by E7 long peptide after either intramuscular or intracervicovaginal vaccination</p>