A5101570789- Liver Disease Diagnosis and Treatment
- Liver Disease and Transplantation
- Liver Diseases and Immunity
- Liver physiology and pathology
- Pediatric Hepatobiliary Diseases and Treatments
- Diet, Metabolism, and Disease
- Hepatitis C virus research
- Hepatocellular Carcinoma Treatment and Prognosis
- Pancreatic and Hepatic Oncology Research
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Gastrointestinal Tumor Research and Treatment
- Hepatitis B Virus Studies
- Helicobacter pylori-related gastroenterology studies
- Peptidase Inhibition and Analysis
- Systemic Lupus Erythematosus Research
- Platelet Disorders and Treatments
- Viral-associated cancers and disorders
- Alcohol Consumption and Health Effects
- Glycosylation and Glycoproteins Research
- Cancer, Lipids, and Metabolism
- Gastrointestinal disorders and treatments
- Cancer-related gene regulation
- Cancer Mechanisms and Therapy
- Cell Adhesion Molecules Research
- Pancreatitis Pathology and Treatment
Nara Medical University
2015-2022
Yokohama City University Medical Center
2017-2019
Yokohama City University
2017-2019
Toho University
2017
Creative Research Enterprises (United States)
2016
Jikei University School of Medicine
2006
Health First
2003
University of Fukui
1996-2002
Kyoto University
1994
Sodium‐glucose cotransporter 2 inhibitors (SGLT2‐Is) comprise a new class of antidiabetic agents that inhibit glucose reabsorption in the renal proximal tubules. Although recent report demonstrated potential ability SGLT2‐Is to attenuate cancer growth SGLT2‐expressing cells, little is known about effects on hepatocellular carcinoma (HCC). Here, we investigate anti‐cancer properties SGLT2‐I, canagliflozin, against human liver cells. SGTL2 mRNA and protein expression were detected Huh7 HepG2...
The purpose of this investigation was to assess the salivary levels Epstein–Barr virus (EBV) in patients with periodontitis using real‐time PCR. EBV detected 16 out 33 (48.5%) and 3 20(15%) healthy subjects. baseline mean values for bleeding on probing EBV‐positive were significantly higher than those EBV‐negative patients. A significant decrease observed after initial periodontal treatment. Our findings indicate that saliva may reflect status inflammation.
The efficacy of the vasopressin V2 receptor antagonist tolvaptan for difficult-to-treat cirrhotic ascites has recently been reported. However, its effect is variable among patients. This study aimed to clarify predictive factors obtaining a good response in patients with ascites.Data were collected from 50 liver cirrhosis having (hepatitis B, n = 1; hepatitis C, 22; alcoholism, 11; and others, 16) after treatment (3.75-7.5 mg/day) addition conventional diuretics. A follow-up assessment was...
Intestinal endotoxin is important for the progression of non-alcoholic steatohepatitis (NASH). Circulating levels are elevated in most animal models diet-induced fatty liver disease (NAFLD) and NASH. Furthermore, plasma significantly higher NAFLD patients, which associated with small intestinal bacterial overgrowth increased permeability. By improving gut microbiota environment restoring gut-barrier functions, probiotics effective NASH treatment models. It also widely known that hepatic...
Abstract Background To investigate the von Willebrand factor to ADAMTS13 ratio as a potential biomarker for early detection of hepatocellular carcinoma (HCC) in cirrhosis. Methods Serum levels alpha-fetoprotein, des-γ-carboxy prothrombin, Lens culinaris agglutinin-reactive fraction alpha-fetoprotein (alpha-fetoprotein-L3%), vascular endothelial growth factor, and receptor-2, well plasma antigen (von factor: Ag) activity (ADAMTS13:AC), were evaluated 41 cirrhotic patients with HCC undergoing...
Dipeptidyl peptidase-4 (DPP4) inhibitors (DPP4-I) are oral glucose-lowering drugs for type 2 diabetes mellitus. Previously, we reported that DPP4-I (sitagliptin) exerted suppressive effects on experimental liver fibrosis in rats. Blockade of the renin-angiotensin system by angiotensin-II 1 receptor blocker (losartan), commonly used management hypertension, has been shown to significantly alleviate hepatic fibrogenesis and carcinogenesis. We aimed elucidate possible mechanisms a sitagliptin +...
Various rodent models have been proposed for basic research; however, the pathogenesis of human nonalcoholic steatohepatitis (NASH) is difficult to closely mimic. Lipopolysaccharide (LPS) has reported play a pivotal role in fibrosis development during NASH progression via activation toll-like receptor 4 (TLR4) signaling. This study aimed clarify impact low-dose LPS challenge on pathological and establish novel murine model. C57BL/6J mice were fed choline-deficient l-amino-acid-defined (CDAA)...
Recent reports have revealed the impact of a western diet containing large amounts fructose on pathogenesis non-alcoholic steatohepatitis (NASH). Fructose exacerbates hepatic inflammation in NASH by inducing increasing intestinal permeability. However, it is not clear whether contributes to progression liver fibrosis and hepatocarcinogenesis NASH. The aim this study was investigate effect intake rat model. A choline-deficient/L-amino acid fed F344 rats induce administrated one group drinking...
Hepatocellular carcinoma (HCC) is prone to recurrence following curative treatment. The purpose of the present study was identify predisposing factors HCC complete remission achieved by transarterial chemoembolization (TACE). A retrospective cohort 70 consecutive patients with who underwent TACE as initial treatment conducted. were divided into two groups according their 1‑year disease‑free survival (DFS) status; early group (ER group; n=32), recurring within 1 year TACE; and non‑early (NER...
Aim The prognosis and natural history of primary biliary cirrhosis (PBC) has improved, the clinical end‐point for PBC needs to be discovered. We aimed identify surrogate markers predicting long‐term in patients with PBC. Methods A total 106 were divided into 53 responders non‐responders based on median rate (69%) decrease γ‐glutamyl transpeptidase levels at 1 year after initiating ursodeoxycholic acid therapy. differences between non‐responders. Correlation patient survival histologic...
Insufficient ADAMTS13 activity (ADAMTS13:AC) leads to increased levels of unusually large von Willebrand factor (VWF) multimers and causes microcirculatory disturbance multiple organ failure (MOF). Endotoxin (Et) triggers the activation coagulation cytokine cascades, leading MOF in severe inflammatory response syndrome. Here, we investigated potential role endotoxemia-related acute cholangitis.Twenty-four patients with cholangitis, including 7 were recruited this study. The ADAMTS13:AC, VWF...
Even though the Barcelona Clinic Liver Cancer (BCLC) staging system is widely accepted, controversies on management of hepatocellular carcinoma (HCC) still exist. We evaluated efficacy an approach with repeated hepatic arterial infusion chemotherapy (HAIC) given at eight-week intervals for treatment advanced HCC.Of 66 compensated cirrhotic patients HCC refractory to transcatheter chemo-embolization (TACE) enrolled in our study, 21 were treated by bi-monthly (B-HAIC) and rest sorafenib. The...
The farnesoid X receptor (FXR) agonist, a bile acid‐activated nuclear receptor, has been shown to improve the histologic features of nonalcoholic steatohepatitis (NASH); however, satisfactory effect on hepatic fibrosis not achieved. We aimed investigate combined FXR agonist and angiotensin II type 1 blocker fibrogenesis in rat models NASH. For 8 weeks, two NASH were developed. Otsuka Long‐Evans Tokushima Fatty (OLETF) rats administered intraperitoneal injections mL/kg pig serum (PS) twice...
Inadequate response to ursodeoxycholic acid (UDCA) is associated with unfavorable outcomes in patients primary biliary cholangitis (PBC). We aimed identify surrogate markers for predicting long-term prognosis and biochemical UDCA PBC.In this single-center, retrospective study, 99 PBC were classified into responders (n=53) nonresponders (n=46) based on reductions the γ-glutamyl transpeptidase levels at 1 year after initiating therapy (Nara criteria). assessed whether criteria patentability by...
To identify laboratory predictors of histological progression (HP) primary biliary cholangitis (PBC).Sequential biopsies were carried out on 35 (11.4%) 308 patients with PBC treated ursodeoxycholic acid (UDCA). Patients divided into high γ-glutamyl transpeptidase (GGT) (n = 18) and low GGT 17) groups, based the median value at baseline. then categorized as showing HP (progressive group, PG) or lacking (non-progressive NPG) according to Scheuer Nakanuma classifications, latter grading liver...
Periostin is a 90‑kDa extracellular matrix protein, which secreted primarily from fibroblasts and expressed in the lungs, kidneys heart valves. Angiotensin II (AT‑II) serves pivotal roles pathogenesis of several diseases with accompanying fibrosis, including chronic liver diseases. AT‑II induces periostin expression by regulating transforming growth factor‑β1 (TGF‑β1)/Smad signaling during cardiac fibrosis. The aim present study was to investigate interaction between fibrosis development....
Sulforaphane (SFN) exhibits inhibitory effects in different types of cancers.However, its effect on liver cancer remains unknown.This study aimed to determine the therapeutic potential SFN for treatment and explore functional mechanisms underlying SFN.Water-Soluble Tetrazolium salt (WST-1) assay was performed assess vitro cell proliferation human lines, HepG2 Huh-7.The mRNA levels Nrf2 target genes cycle-related were determined using quantitative RT-PCR.For assessing vivo, we injected...