A5030007770- Epigenetics and DNA Methylation
- International Arbitration and Investment Law
- RNA modifications and cancer
- Cancer-related gene regulation
- Dispute Resolution and Class Actions
- Corporate Law and Human Rights
- Climate Change Policy and Economics
- Energy, Environment, Economic Growth
- Hippo pathway signaling and YAP/TAZ
- Metastasis and carcinoma case studies
- Environmental law and policy
- Global trade, sustainability, and social impact
- Ubiquitin and proteasome pathways
- Global trade and economics
- State Capitalism and Financial Governance
- Discrimination and Equality Law
- Climate Change and Geoengineering
- World Trade Organization Law
- Cancer Cells and Metastasis
- Histone Deacetylase Inhibitors Research
- Conflict of Laws and Jurisdiction
- Labor Movements and Unions
- Cancer-related molecular mechanisms research
- European and International Contract Law
Peking University
2012-2023
University of Oxford
2012-2023
Science Oxford
2022
King University
2012-2019
Ministry of Education of the People's Republic of China
2015-2019
State Key Laboratory of Natural and Biomimetic Drugs
2015-2019
Yale University
2012-2019
Enhancer of zeste homolog 2 (EZH2) is a key epigenetic regulator that catalyzes the trimethylation H3K27 and modulated by post-translational modifications (PTMs). However, precise regulation EZH2 PTMs remains elusive. We, herein, report acetylated acetyltransferase P300/CBP-associated factor (PCAF) deacetylated deacetylase SIRT1. We identified PCAF interacts with acetylates mainly at lysine 348 (K348). Mechanistically, K348 acetylation decreases phosphorylation T345 T487 increases stability...
HOXB9 is a homeobox domain-containing transcription factor, playing an important role in embryonic development and cancer progression. However, the precise post-translational modifications (PTMs) of corresponding roles are unclear. Here, we report that acetyltransferase p300/CBP-associated factor (PCAF) interacts with acetylates both vivo vitro Conversely, acetylation can be reversed by deacetylase SIRT1. Furthermore, found acetylated at lysine 27 (AcK27). Functionally, contrast to wild type...
The Hippo signaling pathway plays a key role in development and cancer progression. However, molecules that intrinsically inhibit this are less well known. Here, we report the focal adhesion molecule Kindlin-2 inhibits by interacting with degrading MOB1 promoting interaction between E3 ligase praja2. thus phosphorylation of LATS1 YAP promotes translocation into nucleus, where it activates downstream target gene transcription. depletion Hippo/YAP alleviates renal fibrosis knockout mice...
Polycomb repression complex 2 (PRC2) component EZH2 tri-methylates H3K27 and exerts epigenetic on target gene expression. EZH2-mediated control of RNA polymerase II (Pol II) transcribed coding transcription has been well established. However, little is known about regulation III III) transcription. Here we present a paradigm that involved in the Pol via interaction with transcriptional factor IIIC (TFIIIC). H3K27me3 co-occupy promoter tRNATyr, 5S rRNA 7SL genes. Depletion or inhibition...
// Bo Ma 1 , Ji Dong Liu 2 Ling Guo Huiling Chen Jingjin Ding 3 Wei and Hongquan Zhang Department of Human Anatomy, Histology Embryology, Key Laboratory Carcinogenesis Translational Research, Ministry Education, State Natural Biomimetic Drugs, Peking University Health Science Center, Beijing, China Institute Immunology, The Third Military Medical University, Chongqing, Biophysics, Chinese Academy Sciences, Correspondence to: Zhang, email: Liu, Keywords : DNA N6-adenine methyltransferase;...
Abstract The COVID-19 pandemic is reshaping the landscape of Chinese dispute resolution. aim this article to outline China's various approaches such development in times global pandemic. primarily examines features online arbitration China with a special focus on significance party autonomy and authority tribunal handling virtual hearings. This trend prompts question as whether hearings use digital technology ensure protection data privacy. Further, analyses impacts resolution litigation...
Abstract Multinational corporations (MNCs) have enjoyed considerable investment rights and gained massive benefits under international law; at the same time, they also significantly contributed to climate crisis. Yet, do not bear corresponding change obligations. A huge gap between MNC obligations—the investment‐climate gap—persists because of MNCs' global operations, limited reach domestic legal mechanisms in regulating obligations, ineffectiveness regimes addressing This is mainly due...
Abstract The article analyses potential intellectual-property-related disputes amid transfer of technology in the green economy within international investment legal regime. Intellectual property rights (IPRs) protect human innovation and intellectual efforts. Tech transfer, IPRs particular, has an important role to play move towards economy. In reality, it is ‘private-sector-driven’ approach – foreign investment, licensing, export that plays dominant tech transfer. Previously, private...
The Aftermath of Kiobel and Daimler 399 presumption against extraterritorial application, the limitation personal jurisdiction, international comity, among other barriers.The United States seems to have closed door for transnational litigation hold MNEs liable tortious acts offshore subsidiaries.Even though courts are returning their original position prior rise ATS litigation, several strategies impose liability on subsidiaries after might achieve success, including correct application ATS,...
The paper focuses on the settlement of labor dispute through mediation and arbitration in China. In Section I talks about China with statistics analysis disputes China, including collective disputes. And analyzes reasons behind these statistics. II history resolution method arbitration, combining relevant laws regulations. III specific process to resolve based current effective IV characteristics will evaluation approach dispute, advantages limits dispute. V concludes several suggestions. A...
The World Trade Organization (WTO) is a common institutional framework for worldwide trade in goods and services. In anti-dumping area the U.S. European Union (EU) always consider China as non-market economy (NME), which results suffering greater loss compared with treating market economy.