A5069815785- Toxoplasma gondii Research Studies
- Immune Cell Function and Interaction
- Cytomegalovirus and herpesvirus research
- COVID-19 diagnosis using AI
- Immunotherapy and Immune Responses
- Herpesvirus Infections and Treatments
- Cancer Immunotherapy and Biomarkers
- CAR-T cell therapy research
- Retinal Imaging and Analysis
- Anomaly Detection Techniques and Applications
- Digital Imaging for Blood Diseases
- AI in cancer detection
- Bariatric Surgery and Outcomes
- Potassium and Related Disorders
- Bone health and treatments
- Optical Coherence Tomography Applications
- Protein Degradation and Inhibitors
- Obesity, Physical Activity, Diet
- Multiple Myeloma Research and Treatments
- Immune cells in cancer
- Pediatric Hepatobiliary Diseases and Treatments
- Vitamin D Research Studies
- Families in Therapy and Culture
- Research on Leishmaniasis Studies
- Congenital Anomalies and Fetal Surgery
University of Engineering & Management
2022
Pfizer (United States)
2021
The Mining, Geological & Metallurgical Insititute of India
2021
Amrita Institute of Medical Sciences and Research Centre
2021
St. Vincent Charity Hospital
2016-2020
Case Western Reserve University
2016-2017
George Washington University
2009-2016
Institute of Post Graduate Medical Education and Research
2016
ICARE Institute of Medical Sciences and Research & Dr. Bidhan Chandra Roy Hospital
2015
In this study, we document that Toxoplasma gondii differentiation and reactivation are mediated by systemic CD8 T-cell dysfunction during chronic infection. We demonstrate + exhaustion occurs despite control of parasitemia early-chronic toxoplasmosis. During later phases, these cells become exhausted, leading to parasite mortality. Concomitant with increased apoptosis decreased effector response, is characterized a graded elevation in expression inhibitory receptor PD-1 on both lymphoid...
Background Hematopoietic progenitor kinase 1 (HPK1 or MAP4K1) has been demonstrated as a negative intracellular immune checkpoint in mediating antitumor immunity studies with HPK1 knockout and dead mice. Pharmacological inhibition of is desirable to investigate the role human cells therapeutic implications. However, significant challenge remains identify small molecule inhibitor sufficient potency, selectivity, other drug-like properties suitable for proof-of-concept studies. In this report,...
CD8, but not CD4, T cells are considered critical for control of chronic toxoplasmosis. Although CD8 exhaustion has been previously reported in Toxoplasma encephalitis (TE)–susceptible model, our current work demonstrates that CD4 only become exhausted during toxoplasmosis this dysfunction is more pronounced than cells. Exhausted population expressed elevated levels multiple inhibitory receptors concomitant with the reduced functionality and up-regulation Blimp-1, a transcription factor. Our...
We reported earlier that during chronic toxoplasmosis CD8+ T cells become functionally exhausted with concomitant PD-1 upregulation, leading to eventual host mortality. However, how immune exhaustion specifically mediates attrition of CD8 polyfunctionality, a hallmark potent T-cell response, persistent infections has not been addressed. In this study, we demonstrate is preferentially expressed on polyfunctional memory cells, which renders them susceptible apoptosis. vitro blockade the...
CD8 exhaustion mediated by an inhibitory programmed death-1-programmed death ligand-1 (PD-L1) pathway occurs in several chronic infections, including toxoplasmosis. Although blockade of the death-1-PD-L1 revives this response, role costimulatory receptors involved rescue has not been ascertained any model exhaustion. This report demonstrates that one such pathway, CD40-CD40L, plays a critical during exhausted T cells. Blockade abrogates ameliorative effects anti-PD-L1 treatment on...
Automatic detection of sign language from hand gesture images is crucial nowadays. Accurate and classification can help people with hearing speech disorder. In this paper, a deep multi-layered convolution neural network proposed for purpose. the approach, 32 filters 3 x3 kernel, LeakyReLU activation function 2 x2 max pooling operation have been performed in CNN structure. SoftMax has used output layer. The approach evaluated on database containing both static (54000 36 classes) dynamic...
CD8 T cells are essential for control of Toxoplasma gondii infection. Once activated they undergo differentiation into short-lived effector and memory precursor cells. As cells, exert immune pressure on the parasite via production inflammatory cytokines through their cytolytic activity. has been established, encysts develops chronic infection regulated by T-cell population. Several signals needed this process to be initiated development fully differentiated With newly developed tools...
CD8+ T cells play an essential role in the protection against both acute as well chronic Toxoplasma gondii infection. Although of IL-15 has been reported to be important for development long-term cell immunity pathogen, simultaneous roles played by and related γ-chain family cytokine IL-7 generation this response during phase infection not described. We demonstrate that while lack or alone minimal impact on splenic maturation effector function Toxoplasmosis, absence only context severely...
Functional exhaustion of CD8(+) T cells due to increased expression inhibitory molecule PD-1 (Programmed Death-1) causes reactivation latent disease during later phases chronic toxoplasmosis. Onset recrudescence results in decreased parasite cyst burden concomitant with parasites undergoing stage conversion from a primarily encysted, quiescent bradyzoite fast-replicating, highly motile tachyzoite. Thus, reduced is one the early hallmarks recrudescence. This was further validated by depleting...
Advanced age is associated with immune system deficits that result in an increased susceptibility to infectious diseases; however, specific mediators of age-dependent dysfunction have not been fully elucidated. Here we demonstrated aged mice exhibit poor effector CD8+ T cell polyfunctionality, primarily due cell-extrinsic deficits, and reduced polyfunctionality correlates pathogenic diseases. In animals challenged the parasite Encephalitozoon cuniculi, survival were suppressed by highly...
Chronic Toxoplasmosis and CD8 ExhaustionToxoplasmosis caused by Toxoplasma gondii (T.gondii), an obligate intercellular protozoan, is considered to be a leading cause of foodborne mortality in the United States (www.cdc.gov).Even post-HAART era, fatal toxoplasmic encephalitis (TE) due reactivation chronic infection remains major problem Toxoplasma-seropositive AIDS patients developing countries [1].In warm-blooded intermediate hosts (including humans), parasite undergoes stage conversion...
Severe Acute Respiratory Syndrome Corona virus 2 (SARS-COV-2) also known as COVID-19 has been emerged a pandemic throughout the globe recently. Therefore, accurate diagnosis of is necessary to fight against this situation. In context, chest X-ray (CXR) scans play an important role in corona virus. paper, intelligent detection and classification technique proposed assist doctors their diagnostic prediction. A deep multi-layered convolution neural network (CNN) detect accurately from CXR...
Classification of retinal diseases using Optical Coherence Tomographical (OCT) scans is a crucial task. Accurate detection and classification these necessary for patient's survival. Presently, the analysis are carried out by doctors examining OCT images regularly. However manual diagnosis procedure tedious. Therefore, in this paper, an automatic technique has been proposed to assist their diagnosis. A deep multilayered convolutional neural network (CNN) used detect classify abnormalities...
Chronic infectious diseases such as HIV, HBV, and HCV, among others, cause severe morbidity mortality globally. Progressive decline in CD8 functionality, survival, proliferative potential-a phenomenon referred to exhaustion-is believed be responsible for poor pathogen control chronic diseases. While the role of negative inhibitory receptors PD−1 augmenting exhaustion has been extensively studied, positive costimulatory remains poorly understood. In this review, we discuss how one pathway,...
May-Thurner syndrome (MTS) is a clinical condition where the left common iliac vein gets compressed by overlying right artery anterior to fifth lumbar vertebra and sacral promontory. It results in vessel wall injury predisposition thrombosis. We present case of 21-year-old African-American man with no significant past medical history who came emergency department lower limb swelling associated shortness breath, was eventually diagnosed have extensive extremity deep thrombosis (DVT) along...
The increasing demand and popularity of bariatric surgery are not only due to the ever-increasing obesity epidemic but tackle obesity-related comorbidities like diabetes hypertension. However, is free complications. One rare complication intussusception, jejuno-jejunal intussusception being most common. Intussusception has been defined both in pregnant non-pregnant women as well men. We describe case a 40-year-old woman first trimester pregnancy came hospital with worsening abdominal pain,...
Although solitary plasmacytomas may occasionally present as collar bone swellings or fractures, multiple myeloma involving clavicle is extremely rare. Ten to forty per cent of cases are asymptomatic and incidental diagnoses. Our case report describes an entirely benign presentation like chronic shoulder pain masquerading advanced myeloma, thereby posing a significant diagnostic dilemma. We 48-year-old man who presented with bilateral no history trauma was eventually diagnosed pathologic...