A5060642843- Reproductive Health and Contraception
- Hormonal and reproductive studies
- Ovarian function and disorders
- Maternal and fetal healthcare
- Ectopic Pregnancy Diagnosis and Management
- Pregnancy-related medical research
- Uterine Myomas and Treatments
- Injury Epidemiology and Prevention
- Blood Coagulation and Thrombosis Mechanisms
- Cardiac Arrest and Resuscitation
- Emergency and Acute Care Studies
- Gestational Diabetes Research and Management
- Biomarkers in Disease Mechanisms
University of Helsinki
2011-2022
Helsinki University Hospital
2017-2022
Objective The use of combined hormonal contraceptives (CHCs) worsens glucose tolerance, but the risk for metabolism disorders remains controversial. Design study is a prospective longitudinal population-based cohort study. Methods was based on population that comprised 1879 women born in 1966. At age 46, answered questionnaire contraceptive and underwent an oral tolerance test. Glucose indices were evaluated current CHC ( n = 153), progestin-only (POC, 842), non-hormonal users 884). Results...
Abstract Introduction Contraceptives containing ethinylestradiol (EE) induce changes in the coagulation system and are associated with a risk of venous thromboembolism. However, studies comparing effects combined oral contraceptives EE low‐potency estrogens (ie, estradiol [E 2 ] valerate [EV]) on biomarkers limited. This study represents secondary outcomes randomized trial EV + dienogest (DNG), DNG, DNG alone selected biomarkers. We could compare specific different estrogen components owing...
Abstract Context Combined oral contraceptives (COCs) alter inflammatory status and lipid metabolism. Whether different estrogens have effects is poorly understood. Objective We compared the of COCs containing ethinyl estradiol (EE) or valerate (EV) dienogest (DNG) with those DNG only on inflammation Design Randomized, controlled, open-label clinical trial. Setting Two-center study in Helsinki Oulu University Hospitals. Participants Fifty-nine healthy, young, nonsmoking women regular...
Abstract STUDY QUESTION Does an estradiol-based combined oral contraceptive (COC) have a milder effect on the serum proteome than ethinylestradiol (EE)-based COC or dienogest (DNG) only? SUMMARY ANSWER The changes in were multifold after use of synthetic EE-based compared to natural estrogen progestin-only preparation. WHAT IS KNOWN ALREADY COCs widely affect metabolism, inflammation, hepatic protein synthesis and blood coagulation. Studies comparing proteomes containing EE estrogens are...
Limited studies have compared the effects of combined oral contraceptives (COCs) containing natural estrogens and synthetic ethinylestradiol (EE) on reproductive hormones.To compare estradiol valerate (EV) + dienogest (DNG), EE DNG, DNG alone (active control) levels follicle stimulating hormone (FSH), luteinizing hormone, anti-Müllerian (AMH), ovarian steroids, sex binding globulin (SHBG), free androgen index (FAI).This spin-off study from a randomized trial enrolled 59 healthy, 18 to...
Research on the treatment of second-trimester miscarriages is scarce. We studied outcomes, and factors associated with adverse events need for hospital resources in medical miscarriage.In these retrospective analyses we women treated spontaneous fetal miscarriage misoprostol-only (n = 24) or mifepristone misoprostol 177) duration gestation 12+1-21+6. Primary outcomes were risk surgical evacuation excessive bleeding. Secondary total dose, time to expulsion length stay.History uterus increased...
Searchable abstracts of presentations at key conferences in endocrinology ISSN 1470-3947 (print) | 1479-6848 (online)
Searchable abstracts of presentations at key conferences in endocrinology ISSN 1470-3947 (print) | 1479-6848 (online)
Searchable abstracts of presentations at key conferences in endocrinology ISSN 1470-3947 (print) | 1479-6848 (online)