A5083923003- Neuroblastoma Research and Treatments
- Pharmaceutical Economics and Policy
- Service-Learning and Community Engagement
- Interdisciplinary Research and Collaboration
- Innovation and Socioeconomic Development
- Sustainability in Higher Education
- Retinoids in leukemia and cellular processes
- Intellectual Property and Patents
- PARP inhibition in cancer therapy
- Innovative Education and Learning Practices
- Biotechnology and Related Fields
- Community Health and Development
- interferon and immune responses
- Telomeres, Telomerase, and Senescence
- Higher Education Governance and Development
- Innovation and Knowledge Management
- Innovative Approaches in Technology and Social Development
- Mosquito-borne diseases and control
- Social Work Education and Practice
- Ubiquitin and proteasome pathways
- Higher Education Practises and Engagement
- HIV Research and Treatment
- Sustainability and Climate Change Governance
- Conferences and Exhibitions Management
- Ocular Oncology and Treatments
Vrije Universiteit Amsterdam
2017-2025
Amsterdam UMC Location Vrije Universiteit Amsterdam
2018-2024
Texas Tech University
2019-2023
Texas Tech University Health Sciences Center
2019-2023
United Nations University – Maastricht Economic and Social Research Institute on Innovation and Technology
2015-2020
Elabora Consultoria (Brazil)
2018-2019
The University of Texas at El Paso
2012-2016
Universidade Estadual de Campinas (UNICAMP)
2010
Abstract Neuroblastoma is a childhood cancer with heterogeneous clinical outcomes. To comprehensively assess the impact of telomere maintenance mechanism (TMM) on outcomes in high-risk neuroblastoma, we integrated C-circle assay [a marker for alternative lengthening telomeres (ALT)], TERT mRNA expression by RNA-sequencing, whole-genome/exome sequencing, and covariates 134 neuroblastoma patient samples at diagnosis. In addition, assessed TMM cell lines (n = 104) patient-derived xenografts...
Driven by the demand to address complex societal issues, stakeholders from higher education and society increasingly form multi-stakeholder networks. Despite their potential, realising such networks proves complex, often yielding elusive outcomes. To explore how navigate these complexities, this configurative literature review analyses 17 cases, revealing patterns in university-community interactions across network formation, implementation, Two primary modes emerged: Centralised (or...
Abstract Global sustainability challenges transcend disciplines and, therefore, demand interdisciplinary approaches that are characterized by cross-disciplinary collaboration and integration across disciplines. In accordance with this need for approaches, professionals have been reported to require competencies. Although the necessity of competencies is generally agreed upon, there has extensive research understand interdisciplinarity, still no comprehensive understanding how individual...
Poly(ADP-ribose) polymerase 1 (PARP-1) is a cellular enzyme with fundamental role in DNA repair and the regulation of chromatin structure, processes involved response to retroviral integration. However, function PARP-1 integration controversial, probably due functional redundancy PARP family mammalian cells. We evaluated infection using chicken B lymphoblastoid cell line DT40. These cells lack significant efficiently support postentry early events mammalian-retrovirus replication cycle....
Purpose To properly address complex sustainability issues, higher education institutes (HEIs), such as universities, need to implement innovative educational programmes that adhere transdisciplinary principles. This study aims contribute the understanding of how do so across and beyond a university. Design/methodology/approach presents module comprising two courses, first which centres on identification issues in student-led multi-actor dialogue sessions second addressing those through...
Science Shops are structures that facilitate science-society collaborations by providing independent, participatory research support in response to concerns experienced civil society. The current Research and Innovation (R&I) system is under increasing pressure become more inclusive responsive future societal challenges. Responsible (RRI) Open policy imperatives come conceptual practical ways transform the R&I this direction. However, widespread implementation of RRI approaches not yet...
Abstract Recurrent high-risk neuroblastoma is a childhood cancer that often fails to respond therapy. Fenretinide (4-HPR) cytotoxic retinoid with clinical activity in recurrent and venetoclax (ABT-199) selective inhibitor of the antiapoptotic protein B-cell lymphoma-2 (BCL-2). We evaluated 4-HPR + ABT-199 preclinical models neuroblastoma. Patient-derived cell lines xenografts from progressive were tested. Cytotoxicity was by DIMSCAN, apoptosis flow cytometry, gene expression RNA sequencing,...
Abstract Contemporary sustainability issues require the integration of diverse knowledge to study and address them holistically. How interdisciplinary arises in teamwork is, however, poorly understood. For instance, studies often focus on either individual or team processes, rather than studying their interplay thereby contributing understanding an integral manner. Therefore, this we aimed understand how processes are shaped by interactions teamwork. We present insights from ethnographic...
Purpose This paper aims to study how multinational enterprises (MNEs) can best integrate legitimacy concerns into their new product-launching strategy successfully introduce high-value hi-tech innovations in emerging countries. Design/methodology/approach Theoretical constructs on the role and process of construction for introduction a product are built upon existing literature. Then they validated refined through formulation analysis case studies launch genetically modified cotton seeds by...
The purpose of this study is to illustrate how industrial policy can support health through the construction technological and innovation capabilities. This paper provides insights on topic by examining Brazilian ability make patented antiretroviral (ARV) drugs universally accessible people living with HIV/AIDS in country. case demonstrates crucial role making use compulsory licensing price negotiations pharmaceutical multinational corporations improve access ARV drugs. evidence presented...
Universities are under increasing pressure to become more and better involved in society as part of their third mission, which Community Service learning (CSL) can contribute. To date, most CSL projects mono-disciplinary, single courses, often a short-term nature. In order address the increasingly complex problems facing society, there is need adopt multi–and interdisciplinary approaches that allow for range perspectives. The article describes analyzes how thematic approach was initiated at...
A Science Shop acts as a mission-oriented intermediary unit between the scientific sphere and civil society organizations. It seeks to facilitate citizen-driven open science projects that respond needs of organizations which, typically, include students in work process. We performed thematic analysis systematically selected literature on Shops understand how reflects historical evolution different settings what factors associates with rise fall Shop. used PRISMA methodology search for papers...
To gain insight in the potential of current pipeline for rabies to decrease burden disease by evaluating its relevance high-risk countries.Rabies-related patent documents and clinical trials were retrieved from Espacenet WHO ICTRP, respectively. Data cleaned, modulated categorised into a pre-defined set indicators those used (statistical) analyses on number applications, quality type stakeholders involved different geographical areas.Analysis 583 unique families applied period 1954-2017...
Transformative innovation policies (TIP) have emerged as a response to "wicked problems" and build upon literature of mission-oriented policies, transition studies. Despite targeting social challenges, an explicit engagement with the concept justice is lacking in TIP literature. In order widen scope how can be integrated into TIP, we describe two narratives societal transformation. This conceptual paper outlines framework examine dimensions (in terms weak strong directionality)...