A5066927624- Breast Cancer Treatment Studies
- HER2/EGFR in Cancer Research
- Advanced Breast Cancer Therapies
- Breast Lesions and Carcinomas
- Cancer Treatment and Pharmacology
- Cancer Genomics and Diagnostics
- Cancer Risks and Factors
- Cancer Immunotherapy and Biomarkers
- Estrogen and related hormone effects
- Multiple and Secondary Primary Cancers
- Cancer Cells and Metastasis
- Metabolism, Diabetes, and Cancer
- Cancer Diagnosis and Treatment
- Monoclonal and Polyclonal Antibodies Research
- Epigenetics and DNA Methylation
- Genetic factors in colorectal cancer
- Chemokine receptors and signaling
- Cancer-related Molecular Pathways
- Ferroptosis and cancer prognosis
- Radiopharmaceutical Chemistry and Applications
- Ovarian cancer diagnosis and treatment
- Immunotherapy and Immune Responses
- Lung Cancer Treatments and Mutations
- Metastasis and carcinoma case studies
- Esophageal Cancer Research and Treatment
Nanjing Traditional Chinese Medicine Hospital
2025
Fudan University
2010-2025
Huashan Hospital
2025
Shanghai Jiao Tong University
2015-2024
Ruijin Hospital
2015-2024
Guangdong Ocean University
2024
Second Military Medical University
2022
Changhai Hospital
2022
Sun Yat-sen Memorial Hospital
2022
Sun Yat-sen University
2022
Abstract Background Human epidermal growth factor receptor 2 (HER2) low breast cancer was considered as a distinct subtype different from HER2-zero cancer. Our study aimed to investigate the prognostic values of clinicopathological features and recurrence score (RS) in HER2-low hormone (HR)-positive patients. Methods A total 2099 HR + primary female patients diagnosed between Jan 2009 2019 were collected. Tumors with immunohistochemistry 1 /2 negative situ hybridization results defined...
Cancer-associated adipocytes (CAAs), one of the primary stromal components, exhibit intimate crosstalk and release multiple cell factors mediating local systemic biological effects. However, role CAAs in regulation immune responses their potential value clinical treatment triple-negative breast cancer (TNBC) are not well described. Transcriptome sequencing was performed on CAA normal adipocyte (NA) tissues isolated from surgically resected samples TNBC patients healthy controls. Cytokines,...
Triple-negative breast cancer (TNBC) is a heterogeneous disease that characterized by metabolic disruption. Metabolic reprogramming and tumor cell immune escape play indispensable roles in the tumorigenesis leads to TNBC.In this study, we constructed validated two prognostic glutamine gene models, Clusters A B, better discriminate between groups of TNBC patients based on risk. Compared with risk Cluster patients, B tended exhibit survival outcomes higher infiltration. In addition,...
Abstract Background Estrogen receptor (ER), progesterone (PgR), HER2, and Ki67 have been increasingly evaluated by core needle biopsy (CNB) are recommended for classifying breast cancer into molecular subtypes. However, the concordance rate between CNB open excision (OEB) has not well documented. Methods Patients with paired OEB samples from Oct. 2009 to Feb. 2012 in Ruijin Hospital were included. ER, PgR, determined immunohistochemistry (IHC). HER2 IHC 2+ further examined FISH. Cutoff value...
// Wei Wang 1, * , Jiayi Wu Peifeng Zhang 2 Xiaochun Fei 3 Yu Zong 1 Xiaosong Chen Ou Huang Jian-Rong He Weiguo Yafen Li Kunwei Shen Zhu Comprehensive Breast Health Center, Ruijin Hospital, Shanghai Jiaotong University School of Medicine, 200025, P.R. China Department Information Engineering, University, Shanghai, 200240, Pathology Department, These authors contributed equally to this work Correspondence to: Zhu, e-mail: zhuli8@hotmail.com Keywords: breast carcinoma, hormonal receptor...
Metastatic breast cancer (MBC) is a highly heterogeneous disease and bone one of the most common metastatic sites. This retrospective study was conducted to investigate clinical features, prognostic factors benefits surgery patients with initial metastases.From 2010 2015, 6,860 diagnosed metastasis were analyzed from Surveillance, Epidemiology, End Results (SEER) database. Univariate Multivariable analysis used identify factors. A nomogram performed based on selected cox regression result....
CAFs isolated from HER2+ patients secreted higher levels of IL6 which expanded cancer stem cells and activated multiple pathways, then induced trastuzumab resistance in HER2 positive breast cells.
// Yan Fang 1, * , Jiayi Wu Wei Wang 1 Xiaochun Fei 2 Yu Zong Xiaosong Chen Ou Huang Jianrong He Weiguo Yafen Li Kunwei Shen Zhu Comprehensive Breast Health Center, Ruijin Hospital, Shanghai Jiaotong University School of Medicine, 200025, P.R. China Department Pathology, These authors have contributed equally to this work Correspondence to: Zhu, email: zhuli8@hotmail.com Keywords: breast carcinoma, ductal carcinoma in situ, microinvasion, clinico-pathological feature, prognosis Received:...
Abstract Background Novel antibody‒drug conjugates (ADC) have shown great efficacy in HER2-low advanced breast cancer. However, the clinical features of disease still need to be clarified. The current study aims evaluate distribution and dynamic change HER2 expression patients with recurrence outcome those patients. Methods Patients pathologically diagnosed relapsed cancer between 2009 2018 were included. Samples considered HER2-zero when immunohistochemistry (IHC) score was 0, IHC 1 + or 2...
Abstract Background Triple negative breast cancer (TNBC) occurs in approximately 10% to 25% of all patients with and is associated poor prognosis. Neo-adjuvant chemotherapy has been reported produce a higher pathologic complete response (pCR) rate TNBC. If pCR achieved, TNBC had similar survival non-TNBC patients. The aim our study was investigate the protein expression epithelial growth factor receptor (EGFR) neo-adjuvant clinical outcome compared non-TNBC. Methods A total 198 locally...
Purpose Few studies has documented early relapse in luminal B/HER2-negative breast cancer. We examined prognostic factors for among these patients to improve treatment decision-making. Patients and Methods A total 398 with cancer were included. Kaplan-Meier curves applied estimate disease-free survival Cox regression identify factors. Results Progesterone receptor (PR) negative expression was associated higher tumor grade (p<.001) Ki-67 index (p = .010). PR-negative received more...
To investigate the accuracy of core needle biopsy (CNB) in evaluating breast cancer estrogen receptor (ER), progesterone (PR), HER2, and Ki67 status to identify factors which might be associated with value change after CNB. A retrospective study was carried out on 276 patients paired CNB surgically removed samples (SRS). Clinico-pathological as well surgery time interval (STI) between were analyzed determine whether there Five tumor subtypes classified follows: Luminal A, B-HER2-, B-HER2+,...
Breast cancer patients with suspicious axillary lymph node (ALN) at ultrasound and positive fine-needle aspiration (FNA) results were required to receive ALN dissection (ALND), which was not certain in the post-ACOSOG Z0011 era. We aim evaluate metastasis burden these patients, thus illustrate whether they can follow ACOSOG trial procedure. Clinically, T1–2 N0 breast preoperative biopsy (FNA group) or 1–2 sentinel nodes (SLNB retrospectively analyzed. compared between two groups, further...
Background Multidisciplinary treatment (MDT) and adjuvant therapy are associated with improved survival rates in breast cancer. However, nonadherence to MDT decisions is common patients. We developed a smartphone-based app that can facilitate the full-course management of patients after surgery. Objective This study aims investigate influence factors determine whether this improve compliance rate MDTs. Methods Patients who had received diagnosis invasive cancer undergone between March 2013...
Pancreatic ductal adenocarcinoma (PDAC) is a highly aggressive malignancy characterized by dismal prognosis. Treatment outcomes exhibit substantial variability across patients, underscoring the urgent need for robust predictive models to effectively estimate survival probabilities and therapeutic responses in PDAC. Metabolic immune-related genes exhibiting differential expression were identified using TCGA-PDAC GTEx datasets. A genetic prognostic model was developed via univariable Cox...
Aims and background To investigate the clinicopathological characteristics prognosis of breast cancer subtypes classified by quantitative estrogen receptor (ER), progesterone (PR), Her2. Methods study design 923 patients with primary having a median age 53 years who were treated at Cancer Hospital Fudan University in Shanghai between January 2002 June 2004 retrospectively analyzed. Four molecular constructed from immunohistochemical results hormone (HR) Her2 status. HR+ was defined as ER+...
// Jiayi Wu 1 , Yan Fang Lin 2 Xiaochun Fei 3 Weiqi Gao Siji Zhu Yu Zong Xiaosong Chen Ou Huang Jian-Rong He Li Weiguo Yafen and Kunwei Shen Comprehensive Breast Health Center, Ruijin Hospital, Shanghai Jiaotong University School of Medicine, 200025, China Department Clinical Laboratory, Pathology, Correspondence to: Shen, email: kwshen@medmail.com.cn Keywords: breast carcinoma, 21-gene, risk score, clinico-pathologic factors Received: August 31, 2016 Accepted: January 16, 2017 Published:...
Weekly PCb (paclitaxel + carboplatin) in neoadjuvant chemotherapy (NCT) for breast cancer has a high pathological complete remission (pCR) rate. The present study was to identify pCR predictive biomarkers and test whether integrating candidate molecular can improve the accuracy. Ninety-one patients treated with weekly NCT were retrospectively analyzed. Eleven (Tau, β-tubulin III, PTEN, MAP4, thioredoxin, multidrug resistance-1, Ki67, p53, Bcl-2, BAX, ERCC1) detected by immunohistochemistry...