A5082066195- RNA Interference and Gene Delivery
- Neurogenesis and neuroplasticity mechanisms
- Epigenetics and DNA Methylation
- MicroRNA in disease regulation
- NF-κB Signaling Pathways
- Advanced biosensing and bioanalysis techniques
- Immune Response and Inflammation
- Hedgehog Signaling Pathway Studies
- RNA Research and Splicing
- RNA regulation and disease
- interferon and immune responses
Instituto Cajal
2023-2024
ApTOLL is an aptamer selected to antagonize toll-like receptor 4 (TLR4), a relevant actor for innate immunity involved in inflammatory responses multiple sclerosis (MS) and other diseases. The currently available therapeutic arsenal treat MS composed of immunomodulators but, date, there are no (re)myelinating drugs clinics. In our present study, we studied the effect on different animal models MS.
Myelination is the terminal step in a complex and precisely timed program that orchestrates proliferation, migration differentiation of oligodendroglial cells. It thought Sonic Hedgehog (Shh) acting on Smoothened (Smo) participates regulating this process, but these effects are highly context dependent. Here, we investigate development remyelination from three specific transgenic lines: NG2-Cre
Multiple sclerosis (MS) is a chronic neurological disease that currently lacks effective curative treatments. There need to find therapies, especially reverse the progressive demyelination and neuronal damage. Oligodendrocytes form myelin sheath around axons in central nervous system (CNS) oligodendrocyte precursor cells (OPCs) undergo mechanisms enable spontaneously partial repair of damaged lesions. The aim this study was discover small molecules with potential effects demyelinating...
ABSTRACT ApTOLL is an aptamer specifically designed to antagonize Toll-Like Receptor 4 (TLR4), a relevant actor for innate immunity involved in inflammatory responses multiple sclerosis (MS) and other diseases. MS primary demyelinating, chronic, inmune neurodegenerative disease of the central nervous system that normally debuts young adults. The currently available therapeutic arsenal treat composed immunomodulators but, date, there are no (re)myelinating drugs clinics. Our present study...
ABSTRACT Myelination is the terminal step in a complex and precisely timed program that orchestrates proliferation, migration differentiation of oligodendroglial cells. It thought Sonic Hedgehog (Shh) acting on Smoothened (Smo) participates regulating this process, but these effects are highly context dependent. Here, we investigate development remyelination from three specific transgenic lines: NG2-Cre ERT2 (control), Smo fl/fl /NG2-Cre (loss function) SmoM2/NG2-Cre (gain function), as well...