Ranyelison Silva Machado

ORCID: 0000-0002-5384-8991
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Research Areas
  • Phytochemistry Medicinal Plant Applications
  • Essential Oils and Antimicrobial Activity
  • Cardiac tumors and thrombi
  • Tumors and Oncological Cases
  • Medicinal Plants and Neuroprotection
  • Phytochemicals and Antioxidant Activities
  • Complementary and Alternative Medicine Studies
  • Insect and Pesticide Research
  • Cholinesterase and Neurodegenerative Diseases
  • Sarcoma Diagnosis and Treatment
  • Computational Drug Discovery Methods
  • Rural Development and Agriculture
  • Health, Nursing, Elderly Care
  • Morinda citrifolia extract uses
  • Bee Products Chemical Analysis
  • Insect Pest Control Strategies
  • Toxin Mechanisms and Immunotoxins
  • Global Public Health Policies and Epidemiology
  • Biosimilars and Bioanalytical Methods
  • Palliative and Oncologic Care
  • Leprosy Research and Treatment
  • Dye analysis and toxicity
  • Natural product bioactivities and synthesis

Centro Universitário Maurício de Nassau
2020-2022

Universidade Federal do Piauí
2020

In this paper, we complement our previous study on the antiproliferative activity of Calea fruticosa (Asteraceae) by isolating compounds apigenin-4',7-dimethyl ether (1), budlein A (2), quercetin (3), and cichoriin (4) from plant's aerial parts. The these was evaluated 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) method against human tumor cell lines. Compound 3 displayed moderate in three lines (HCT-116, PC-3, SF-295, with growth inhibition values 72.97, 74.55, 68.94%)...

10.1590/1414-431x20209375 article EN cc-by Brazilian Journal of Medical and Biological Research 2020-01-01

Objetivo: avaliar o perfil epidemiológico da hanseníase nas regiões Norte e Nordeste do Brasil entre os anos de 2015 2018. Metodologia: trata-se uma pesquisa epidemiológica descritiva, retrospectiva com abordagem quantitativa. Os dados mostram a caracterização quanto ao sexo, faixa etária classificação operacional dos casos confirmados Resultados: avaliação epidemiológicos apontou total 63.051 diagnosticados no período analisado. Ao investigar hanseníase, observou-se que 56% ocorreram sexo...

10.33448/rsd-v9i8.6313 article PT Research Society and Development 2020-08-01

Abstract The process involved in the research, discovery and development of drugs is characterized by high extensive complex cost linked to scientific technological innovations, it necessary study verify progress research carried out field that results patent applications. Aniba riparia (Nees) Mez a plant species often used for therapeutic purposes, where its pharmacological properties are associated presence alkaloids called riparins. 5 synthetic analog compounds (riparins A, B, C, D, E F)...

10.1101/2020.04.24.059626 preprint EN cc-by-nd bioRxiv (Cold Spring Harbor Laboratory) 2020-04-27

Objetivo: Caracterizar a importância das abelhas sem ferrão e os estudos de atividade antimicrobiana toxicidade méis Melipona rufiventris fasciculata. Metodologia: Foi realizado revisão bibliográfica nas bases dados: Scientific Electronic Library Online (SciElo), Google Acadêmico PubMed. Sendo selecionados artigos, monografias, dissertações teses, datados entre 2005 2020, nos idiomas inglês, português espanhol. A busca foi realizada por meio dos descritores: mel, toxicidade, agentes...

10.33448/rsd-v9i8.6325 article PT Research Society and Development 2020-08-01

Alzheimer's disease is characterized by a progressive decline of cognitive functions. The class drugs used for the treatment are acetylcholinesterase inhibitors. Essential oils have contributed to folk medicine and discovery new long time. purpose study was investigate in vitro silico anti-acetylcholinesterase activity, as well acute toxicity essential oil Lippia origanoides. EOLO obtained hydrostelting analyzed gas chromatography-mass spectrometry. inhibition assay enzyme activity evaluated...

10.20944/preprints202109.0261.v1 preprint EN 2021-09-15

INTRODUÇÃO: A riparina B apresenta atividades farmacológicas significativas, tais como efeitos ansiolíticos e antidepressivos em modelos animais ansiedade depressão. Entretanto, há um “gap” quanto a estudos toxicológicos. OBJETIVO: Avaliar toxicidade por dose única da in vivo, com intuito de verificar sua segurança para uso substância bioativa formulações farmacêuticas. MÉTODOS: O estudo experimental vivo ocorreu acordo adiretriz 423, preconizada pelo guia ensaios toxicológicos Guideline for...

10.52600/2763-583x.bjcr.2022.2.suppl.3.715-720 article PT cc-by Brazilian Journal of Case Reports 2022-11-04
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