Since vitamin D is a recent known immunoregulatory factor in some diseases which are addressed immune system disorders such as SLE, [psoriasis] and others.To determine the serum levels of 25-hydroxy D3 [25(OH)D] patients with acne vulgaris its association clinical features.This cross-sectional study was conducted over months. This included 39 40 healthy controls. Subjects who did not use alcohol, supplements, oral steroids or PUVA and/or NBUVB for more than three months were included. Serum...

Increased reactive oxygen species (ROS) and lipid peroxidation are seen in many dermatologic disorders, for example, atopic dermatitis, psoriasis, vitiligo, acne vulgaris, pemphigus vulgaris (PV), lichen planus, alopecia areata. ROS has an important role the inflammation process. In PV, increased production of leads to decline antioxidants plasma red blood cells which results oxidative stress. We aimed evaluate level these PV patients compare it controls.Among attending dermatology clinics,...

Background . Prolactin (PRL) level is proposed to be associated with the severity of psoriasis although previous studies reported different results. Objective To find association between PRL levels and before after treatment. In addition, we aimed a difference in prolactin, thyroid stimulating hormone (TSH), hormones (T 3 T 4 ), cortisol patients normal controls. Methods First, were measured 30 matched The was assessed by area index (PASI). Then, treated, PASI every week until achieving...

Abstract Background Non‐cultured cellular grafting as a surgical procedure is indicated to treat stable vitiligo, refractory medical treatment, and gaining wider acceptance among dermatologists. Objective The aim of this study was assess the efficacy non‐cultured melanocyte‐keratinocyte transplantation (MKT) for treatment generalized vitiligo in Iranian patients. Methods In clinical trial, total 14 patches eight patients were treated; with MKT six dermabraded alone without application...

The association between psoriasis and cardiovascular diseases is well documented, but the underlying mechanisms remain unknown. Overexpression of osteopontin (OPN) has been reported in plasma patients with psoriasis, increased risk factors these patients. Selenium compounds are effective downregulating OPN expression. We investigated levels OPN, selenium prolactin (PRL) their metabolic status to identify a possible link markers observed comorbidities. Plasma samples from 40 age‐ sex‐matched...

Objective: To evaluate the true efficacy of 308-nm excimer laser for darkening striae alba using a modified approach. Methods: Ten subjects were treated on white lines striae, while normal skin near to and between was covered with zinc oxide cream. Assessment performed by colorimetric scores based mexameter measurement also digital photographs showing before–after therapy, which compared two independent dermatologists. Results: The mexameter-based data analysis showed that weakly effective...

Injection of botulinum toxin into certain areas face that carry a high risk ptosis (danger zone) needs caution in application. An example is the lateral forehead, particularly lower portion.In this study, we evaluated efficacy and safety treating supraciliary wrinkles forehead by injections at temporal hairline, keeping reasonable distance from danger zone.In randomized clinical trial, 40 women (mean age 35 years) were selected divided two groups, A B. both groups treated with to treat frown...

Background . Morphea is an inflammatory disease of the connective tissue that may lead to thickening and hardening skin due fibrosis. The aim this study was document magnetic resonance imaging (MRI) changes in patients with linear morphea who were treated methotrexate (MTX) high-dose corticosteroid. Methods This conducted on 33 from outpatient’s dermatology clinic our institute, fulfilled inclusion criteria. Patients received 15 mg/week MTX monthly pulses methylprednisolone for three days...

Abstract Background Immunofluorescence antigen mapping (IFM), is a newly introduced technique for diagnosis and classification of epidermolysis bullosa (EB) disease. The precise level skin cleavage can be determined using monoclonal antibodies to EB‐specific basement membrane zone protein. Objective To apply IFM in EB identify utility limitation this method our clinical setting. Methods was done according described protocol by Pohla‐Gubo et al . Monoclonal used were against cytokeratin 5,...

The association between psoriasis and cardiovascular disease is well documented, but the underlying mechanisms remain unknown. relationship osteopontin has been studied. High serum levels of are reported in psoriasis, with increased risk factors these patients.We evaluate extent subclinical atherosclerosis by measuring mean intima-media wall thickness (MIMT) common carotid artery (CCA) patients assessing its correlation to identify vascular associated psoriasis.Intima-media CCA plasma were...

Clinical and histological features may overlap between lichen planopilaris-associated discoid lupus erythematosus-associated scarring alopecia. The aim of this study was to demonstrate the cutaneous infiltration plasmacytoid dendritic cells compare their distribution pattern in erythematosus planopilaris. Twenty-four cases 30 planopilaris were examined for immunostaining CD123 marker. percentage presence clusters evaluted samples. number higher specimens. Aggregations 10 or more (large...

During the recent years, many diagnostic methods have been proposed aiming at early detection of malignant melanoma. The texture skin lesions is an important feature to differentiate melanoma from other types lesions, and different techniques designed quantify this feature. In paper, we discuss a new approach based on independent component analysis (ICA) for extraction features in clinical images.After preprocessing segmentation images, that describe show high discriminative characteristics...

Most people are Exposed to Extremely Low-Frequency Electromagnetic Fields (ELF-EMF). A number of studies have indicated association between exposure extremely low frequency electromagnetic fields and a variety cancers. Recently some therapeutic techniques such as repetitive Transcranial Magnetic Stimulation (rTMS) been used study localization brain function, connectively regions pathophysiology neuropsychiatric disorders (rTMS utilize frequency-electromagnetic field). Here, the effect...

Despite their prevalence, there is a paucity of information in the medical literature on treatment atrophic chickenpox scars.To evaluate efficacy and safety using chemical reconstruction skin scar technique for facial scars.One hundred patients (mean age 23 years; Fitzpatrick types II-IV) were treated with focal peeling 70% trichloroacetic acid (TCA) maximum six sessions. Improvement rate, frequency adverse events patient satisfaction assessed.Five thirty-three sessions 100 consecutive...

Early detection of skin cancers by screening could be very beneficial to decrease their morbidity or mortality. There is limited study about cancer in Iran.This essay was planned as a pilot campaign Tehran, Iran evaluate its profit and failure further design large-scale program more definitely.Thirty one public health centers Shahid Beheshti Medical University were selected different areas Tehran. The project announced via media invited all the people above 40 years old come for whole-body...

Abstract Background Promoter polymorphisms of the macrophage migration inhibitory factor gene are associated with increased production factor. Elevated levels have been observed in sera patients pemphigus vulgaris. More than this, promoter polymorphism has found to confer risk susceptibility chronic inflammatory diseases. Objective We investigated whether there is an association between and Methods One hundred six vulgaris, a control panel one healthy volunteers were genotyped for single...

Pemphigus vulgaris is an autoimmune blistering skin disease with unknown etiology. Drugs such as angiotensin-converting enzyme (ACE) inhibitors may contribute in the pathogenesis of pemphigus.We plan this essay to evaluate serum ACE level pemphigus patients comparison healthy controls recognize its possible role or activity.This study was planned and performed dermatology clinics Shahid Beheshti University MedicalSciences' Hospitals between July 2010 June 2011. Patients new onset were...