A5001775216- Cardiac Arrest and Resuscitation
- Trauma and Emergency Care Studies
- Tuberculosis Research and Epidemiology
- Emergency and Acute Care Studies
- Injury Epidemiology and Prevention
- Acute Myocardial Infarction Research
- Pneumonia and Respiratory Infections
- Down syndrome and intellectual disability research
- Mechanical Circulatory Support Devices
- Mycobacterium research and diagnosis
- Electromagnetic Compatibility and Noise Suppression
- Disaster Response and Management
- HIV/AIDS Impact and Responses
- Pneumocystis jirovecii pneumonia detection and treatment
- Heart Failure Treatment and Management
- Chronic Disease Management Strategies
- Breast Cancer Treatment Studies
- HER2/EGFR in Cancer Research
- Fungal Infections and Studies
- Electromagnetic Compatibility and Measurements
- Antifungal resistance and susceptibility
- Drug Transport and Resistance Mechanisms
- Cardiac Structural Anomalies and Repair
- Sepsis Diagnosis and Treatment
- Family and Disability Support Research
Queensland Government
2020-2025
The Royal Melbourne Hospital
2015-2024
The University of Melbourne
2017-2024
Ambulance Service of New South Wales
2023-2024
Australian Institute of Tropical Health and Medicine
2017-2021
James Cook University
2017-2021
Queensland University of Technology
2017-2018
Defence Science and Technology Group
2009-2015
Monash University
2013-2015
Peter Doherty Institute
2015
A new series of chalcones (4a-c) and allylicchalcones (11a-b) have been prepared by the Claisen-Schmidt condensation. novel pyrazolicchalcones (5a-c) synthesized reaction respective hydrazine hydrate. The structures compounds were confirmed spectral data (infrared spectroscopy 1H nuclear magnetic resonance). All (4/5a-c 11a-b) tested for their antimicrobial activities (agar disc-diffusion method) antioxidant (1,1-biphenyl-2-picrylhydrazyl free radical scavenging method). test failed to show...
Accurate diagnosis and subsequent treatment of latent tuberculosis infection (LTBI) is essential for TB elimination. However, the absence a gold standard test diagnosing LTBI makes assessment true prevalence accuracy diagnostic tests challenging. Bayesian class models can be used to make inferences about disease sensitivity specificity using data on concordance between tests. We performed largest meta-analysis date aiming evaluate performance tuberculin skin (TST) interferon-gamma release...
Background There is concern about widespread medication use by people with intellectual disability (ID), especially psychotropic and anticonvulsant agents. However, there sparse information on prescribing patterns in Australia.Method This cross-sectional study was conducted between 2000 2002 among adults ID who live the community Brisbane, Australia. Medication data were extracted from a health screening tool. Demographic medical collected telephone interviews records.Results Of 117...
Aim This study aims to explore regional variation and identify regions within Australia with high incidence of out-of-hospital cardiac arrest (OHCA) low rates bystander cardiopulmonary resuscitation (CPR). Method Adult OHCAs presumed medical aetiology occurring across between 2017 2019 were mapped onto local government areas (LGA) using the location coordinates. Bayesian spatial models applied provide “smoothed” estimates OHCA CPR (for bystander-witnessed OHCAs) for each LGA. For state...
Latent tuberculosis infection (LTBI) is a critical driver of the global burden active TB, and therefore LTBI treatment key for TB elimination. Treatment regimens include self-administered daily isoniazid 6 (6H) or 9 (9H) months, rifampicin plus 3 months (3RH), 4 (4R) weekly rifapentine (3HP-SAT) administered by healthcare worker as directly observed therapy (3HP-DOT). Data on relative cost-effectiveness these are needed to assist policymakers clinicians in selecting an regimen.To evaluate...
This study aims to assess the impact of COVID-19 pandemic on out-of-hospital cardiac arrest (OHCA) incidence, bystander cardiopulmonary resuscitation (CPR), EMS attempts and survival across Australia New Zealand. Data were extracted for all OHCAs patients attended by emergency medical services (EMS) between 2017 2021 from Aus-ROC OHCA Epistry (Epidemiological registry). Logistic regression was used explore differences pre-COVID-19 (January 1, March 15, 2020) (March 16, 2020 December 31,...
OBJECTIVES Emergency ambulance services are an essential component of rapid treatment prehospital ST-segment elevation myocardial infarction (STEMI). The effectiveness and safety fibrinolysis in older STEMI patients is unknown. This study investigated the paramedic-administered ≥ 75 years age who were identified by paramedics Queensland, Australia.
The primary objectives were to investigate the prescribing practices of antifungal prophylaxis (PAP) and incidence invasive fungal disease (IFD) in adult patients with ALL receiving induction-consolidation chemotherapy. Secondary determine risk factors for IFD resource utilization associated IFD. A retrospective chart review from commencement induction until completion consolidation chemotherapy was undertaken January 2008 June 2013 four hospitals Melbourne, Australia. classified according...
Abstract Objectives To describe the characteristics and outcomes of cardiopulmonary resuscitation (CPR)‐induced consciousness patients from a large database out‐of‐hospital cardiac arrest (OHCA). Methods Included were adult patients, attended between January 2007 December 2018 by Queensland Ambulance Service, where was attempted paramedics. Manual review records undertaken to identify CPR‐induced cases. Patients exhibiting purposeful limb/body movement during CPR, with or without displaying...
ABSTRACT Purpose Information on the use of psychotropic medications in adolescents with intellectual disability is scant. Such information can guide interventions to improve medication this population. We investigated prevalence of, and factors associated with, Australia who live community. Methods Cross‐sectional data were obtained from living community South East Queensland, Australia, between February 2007 September 2010. Self‐reported was extracted a health screening tool. Demographic...
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Tuberculosis (TB) is now the world’s leading infectious killer and major programmatic advances will be needed if we are to meet ambitious new End TB Targets. Although mathematical models powerful tools for control, such must flexible enough capture complexity heterogeneity of global epidemic. This includes simulating a disease that affects age groups other risk differently, has varying levels infectiousness depending upon organ involved outcomes from treatment on drug resistance pattern...
The health impacts of temperatures are gaining attention in Australia and worldwide. While a number studies have investigated the association with risk cardiovascular diseases, few examined out-of-hospital cardiac arrest (OHCA) none done so Australia. This study exposure-response relationship between temperatures, including heatwaves OHCA Brisbane,
Survival from out-of-hospital traumatic cardiac arrest (TCA) is poor. Regional variation exists regarding epidemiology, management and outcomes. Data on prognostic factors are scant. A better understanding of injury patterns outcome determinants key to identifying opportunities for survival improvement.Included were adult (≥18 years) TCA due blunt, penetrating or burn injury, who attended by Queensland Ambulance Service paramedics between 1 January 2007 31 December 2019. We compared the...
Extracorporeal cardiopulmonary resuscitation (E-CPR) is a method of CPR that passes the patient's blood through an extracorporeal membrane oxygenation (ECMO) device to provide mechanical haemodynamic and support in cardiac arrest patients who are not responsive conventional (C-CPR). E-CPR being adopted rapidly worldwide despite absence high quality trial data its substantial cost. Published cost-effectiveness for scarce.We developed mathematical model estimate relative C-CPR adult with...
Tuberculosis (TB) exhibits considerable spatial heterogeneity, occurring in clusters that may act as hubs of community transmission. We evaluated the impact an intervention targeting TB hotspots a rural region Ethiopia. To evaluate targeted active case finding (ACF), we used spatially structured mathematical model has previously been described. From equilibrium, simulated hotspot-targeted strategy (HTS) on incidence ten years from commencement and associated cost-effectiveness. HTS was also...
Background: Field identification and treatment of ST-segment elevation myocardial infarction (STEMI) by paramedics is an important component the continuum care for these patients. This study described real-world clinical practice in prehospital management STEMI patients Queensland, Australia. Methods: Retrospective analysis data sourced from database Queensland Ambulance Service, Adult identified between February 2008 December 2018 were included. Key aspects described. Clinically-important...
Abstract Background Longitudinal data on medication use in adults with intellectual disability (ID) are scarce. We describe the longitudinal of and factors associated psychotropic prescribing ID living Australian community. Methods were obtained from community Queensland, Australia, between 1999 2015. Participant characteristics information extracted baseline questionnaires health check booklets. Logistic regression was used to investigate associations participant use, commencement or...
Little is known about the transmission dynamics of Acinetobacter baumannii in hospitals, despite such information being critical for designing effective infection control measures. In absence comprehensive epidemiological data, mathematical modelling an attractive approach to understanding process. The statistical challenge estimating parameters from data arises fact that most patients are colonised asymptomatically and therefore process not fully observed. Hidden Markov models (HMMs) can...