A5079177140- Congenital Heart Disease Studies
- Cardiovascular Function and Risk Factors
- Cardiovascular Effects of Exercise
- Cardiovascular and exercise physiology
- Body Composition Measurement Techniques
- Hemoglobinopathies and Related Disorders
- Pulmonary Hypertension Research and Treatments
- Cardiac pacing and defibrillation studies
- Iron Metabolism and Disorders
- Heart Failure Treatment and Management
- Cardiac Arrhythmias and Treatments
- Cardiac Structural Anomalies and Repair
- Chemotherapy-induced cardiotoxicity and mitigation
- Pectus Deformity Diagnosis and Treatment
- Cardiac Valve Diseases and Treatments
- Liver Disease and Transplantation
- Restraint-Related Deaths
- Cardiac Arrest and Resuscitation
- Nutrition and Health in Aging
- Aortic Disease and Treatment Approaches
- Childhood Cancer Survivors' Quality of Life
- Heart Rate Variability and Autonomic Control
- Obesity, Physical Activity, Diet
- Cardiac electrophysiology and arrhythmias
- COVID-19 Clinical Research Studies
University of Cincinnati Medical Center
2018-2025
Cincinnati Children's Hospital Medical Center
2016-2025
University of Cincinnati
2020-2022
National Heart Institute
2020
Lankenau Heart Institute
2017
To investigate the relationship between handgrip strength (HGS) and sex, anthropometrics, body composition, cardiovascular fitness has not been well studied in children, adolescents, young adults. A single-center retrospective review of patients <25 years old without known heart disease referred for clinical cardiopulmonary exercise testing was performed. Each patient underwent HGS testing, bioelectrical impedance composition analysis, testing. Relationships variables were assessed using...
Background Adults with a Fontan circulation tend to have myopenia and elevated adiposity when measured by dual energy x-ray absorptiometry. Bioelectrical impedance analysis is an alternative validated approach assess body composition. We used bioelectrical compare composition between pediatric patients control individuals without heart disease. Methods Results A retrospective chart review identified all aged <22 years who presented for cardiopulmonary exercise testing from April 2019 January...
Abstract Objective: Syncope is common among pediatric patients and rarely pathologic. The mechanisms for symptoms during exercise are less well understood than the resting mechanisms. Additionally, inert gas rebreathing analysis, a non-invasive examination of haemodynamics including cardiac output, has not previously been studied in youth with neurocardiogenic syncope. Methods: This was retrospective (2017–2023), single-center cohort study ≤ 21 years prior peri-exertional syncope evaluated...
https://youtu.be/GXnuSdJERKg PURPOSE Low lean muscle mass, or sarcopenia, is common in the context of advanced cardiac dysfunction and heart failure. We conducted a retrospective study to evaluate associations between sarcopenia cardiopulmonary exercise testing (CPET) indices adolescent young adult patients undergoing at freestanding children’s hospital. METHODS reviewed 1658 clinically referred CPETs with simultaneous bioimpedance analysis (BIA, InBody570, Cerritos, CA, USA) performed...
ABSTRACT Introduction Cardiorespiratory fitness (CRF) measured by oxygen consumption (V˙O 2 ) during exercise is an important marker of health. The traditional method indexing V˙O to total body mass suboptimal because skeletal muscle (SMM), rather than fat and extracellular fluid, the main contributor CRF. estimating equations for peak in youth do not account this. Bioelectric impedance analysis (BIA) a noninvasive accurately measure composition. objectives this study were 1) examine...
Background Portal hypertension in the Fontan circulation is a function of elevated systemic venous pressure and liver fibrosis. Purpose To quantify prevalence radiologic evidence portal VAST score (one point each for varices, ascites, splenomegaly, thrombocytopenia) 2 or greater children adults with to determine association hemodynamics adverse outcomes. Materials Methods This was retrospective study individuals who underwent abdominal MRI CT focal lesion surveillance between January 2012...
Abstract Background Left ventricular diastolic dysfunction (DD) is an independent risk factor for mortality in sickle cell anemia (SCA) and associated with increased extracellular volume (ECV) on cardiac MRI (CMR). Exercise impairment common SCA, but its causes prognostic value are not well understood. Objective To study the effects of DD ECV cardiopulmonary exercise test (CPET) patients SCA. Methods Results As part a prospective to characterize cardiomyopathy SCA (NCT02410811), 20 children...
Abstract Increased extracellular volume (ECV) by CMR is a marker of interstitial myocardial fibrosis and associated with diastolic dysfunction in sickle cell anemia (SCA). Left atrial (LA) stiffness contribute to the development heart failure other settings. We aimed evaluate LA function associations ECV, tricuspid regurgitation jet velocity (TRV) exercise abnormalities SCA. In prospective study, individuals SCA underwent CMR, echocardiography test. ECV was measured using MOLLI sequence....
Elevated central venous pressure (CVP) plays an important role in the development of adverse Fontan outcomes. Peripheral (PVP) has been validated as a surrogate for CVP patients. We hypothesised that PVP response to exercise will be associated with greater prevalence morbidity.Adult patients had cardiopulmonary testing (CPET) monitoring upper extremity between 2015 and 2018. at rest, during unloaded cycling peak was compared those without outcomes including arrhythmia, unscheduled hospital...
Purpose: The cardiopulmonary exercise test (CPET) is a valuable tool to assess capacity in pediatric oncology patients after chemotherapy. In addition, few studies on the utility of submaximal testing have been performed, which could be important as some are unable complete maximal effort secondary deconditioning by both disease and treatment. Materials Methods: We performed retrospective chart review cancer exposed chemotherapy from 1992 2013 who underwent CPET with cycle ergometry (n=27)....
The cardiopulmonary exercise test (CPET) is a valuable tool to assess patient's aerobic fitness and cardiac function, including the response stress. There have been few studies using CPET evaluate capacity in patients with Fabry disease. We performed retrospective chart review of disease from 2001 2016, compared age, gender, size‐matched normal controls. A total 18 were evaluated Bruce protocol (treadmill) 11 ramp (cycle ergometer). group demonstrated significantly lower heart rate at peak...
Clinicians evaluating pediatric patients with unexplained dyspnea on exertion (DOE) often obtain exercise testing a treadmill-based exercise-induced bronchospasm (EIB) protocol measuring only changes in spirometry. We modified the EIB to collect metabolic and lung volume endpoints as obtained cardiopulmonary test (CPET). tested hypothesis that data (EIB-CPET) would yield greater diagnostic information than protocol.
Abstract Background A transannular patch is often used in the contemporary surgical repair of tetralogy Fallot. This can lead to significant pulmonary insufficiency and increased right ventricular volumes ultimately valve replacement. Cardiopulmonary exercise testing assess capacity Fallot patients before There only few published literatures on how lung function affects functional repaired with a patch. Methods retrospective chart review was done from 2015 2017 who underwent maximal effort...
Pectus excavatum (PE) is a common congenital chest wall deformity with various associated health concerns, including psychosocial impacts, academic challenges, and potential cardiopulmonary effects.
Congenital diaphragmatic hernia (CDH) survivors are at risk for long-term exercise impairment and pulmonary morbidity, but the generalizability of prior reported cohorts limited by reduced disease severity older surgical eras. We assessed mid-childhood function outcomes in a contemporary cohort CDH survivors.In this retrospective study, we identified 36 consecutive pediatric who underwent cardiopulmonary testing (CPET) spirometry from 2014 to 2021. Inferential statistics compared with age-,...
Abstract Purpose Sickle cell anemia (SCA) patients frequently have many comorbidities, including diastolic dysfunction (DD) and exercise intolerance. SCA often cannot reach maximal effort on testing; little is known regarding whether submaximal parameters can predict abnormal results in if there are any possible associations with DD. Methods A prospective longitudinal study was performed patients. All had a resting cardiac MRI (CMR), cardiopulmonary test (CPET) cycle ergometry using ramp...
Background Cardiac MRI (CMR) derived ventricular global function index (GFI), a ratio of stroke volume to the sum mean cavity and myocardial volumes, has demonstrated improved prediction clinical outcomes in adults with atherosclerotic disease over ejection fraction. We sought assess CMR GFI novel modification that accounts for unique loading conditions patients repaired tetralogy Fallot (rTOF) determine its correlation exercise performance. Methods Results Seventy‐five rTOF who underwent...