A5062561380- Inhalation and Respiratory Drug Delivery
- Microencapsulation and Drying Processes
- Aerosol Filtration and Electrostatic Precipitation
- Drug Solubulity and Delivery Systems
- Cancer Cells and Metastasis
- Combustion and Detonation Processes
- Cancer-related Molecular Pathways
- RNA modifications and cancer
- Cancer-related gene regulation
- Microbial Inactivation Methods
- Head and Neck Cancer Studies
- Epigenetics and DNA Methylation
- Mesenchymal stem cell research
- Viral gastroenteritis research and epidemiology
- Tissue Engineering and Regenerative Medicine
- Immune Cell Function and Interaction
- RNA Interference and Gene Delivery
- 3D Printing in Biomedical Research
- Analytical Chemistry and Chromatography
- Advanced Drug Delivery Systems
- Microfluidic and Bio-sensing Technologies
- Salmonella and Campylobacter epidemiology
- Escherichia coli research studies
- Scientific Measurement and Uncertainty Evaluation
- Electrohydrodynamics and Fluid Dynamics
Institute for Medical Research
2009-2024
Gilead Sciences (United States)
2024
Ministry of Health
2023
Commonwealth Scientific and Industrial Research Organisation
2018
Swinburne University of Technology Sarawak Campus
2018
Queensland University of Technology
2018
Multimedia University
2018
International Medical University
2018
RMIT University
2018
National University of Malaysia
2018
In the past decades, human umbilical cord-derived mesenchymal stem cells (hUC-MSCs) have sparked interest in cellular therapy due to their immunomodulatory properties. Nevertheless, fate of hUC-MSCs body remains poorly understood. This study aimed investigate biodistribution, homing and clearance systemically administered healthy BALB/c mice model. were labelled with GFP-Luc2 protein, followed by characterisation flow cytometry. Upon intravenous infusion transduced into mice, dynamically...
Abstract Background In Malaysia, Shigella spp. was reported to be the third commonest bacterial agent responsible for childhood diarrhoea. Currently, isolation of bacterium and confirmation disease by microbiological biochemical methods remain as "gold standard". This study aimed detect prevalence four virulence genes present concurrently, in randomly selected Malaysian strains via a rapid multiplex PCR (mPCR) assay. Methods A mPCR assay designed simultaneous detection chromosomal-...
Background: Existing literature has shown that high relative humidity (RH) affects in vitro aerosol drug delivery of nebulizer and pressurized metered dose inhaler (pMDI) formulations. The aim this study is to investigate mouth–throat deposition lung selected solution suspension pMDI formulations, under a range RH, temperature, flow rate conditions. Methods: Alberta Idealized Throat was connected collection filter placed an environmental control chamber. formulations were beclomethasone...
Nasopharyngeal carcinoma (NPC) is a type of cancer endemic in Asia, including Malaysia, Southern China, Hong Kong and Taiwan. Treatment resistance, particularly recurring cases, remains challenge. Thus, studies to develop novel therapeutic agents are important. Potential compounds may be effectively examined using two-dimensional (2D) cell culture models, three‑dimensional (3D) spheroid models or vivo animal models. The majority drug assessments for cancers, NPC, currently performed with 2D...
Subpopulations of nasopharyngeal carcinoma (NPC) contain cells with differential tumourigenic properties. Our study evaluates the potential CD24, CD44, EpCAM and combination EpCAM/CD44 in NPC. CD44br EpCAMbr enriched for higher S-phase cell content, faster-growing leading to tumours larger volume mitotic figures. Although significantly tumour-initiating (TICs), all could retain self-renewal property at least four generations. Compared CD44 marker alone, EpCAM/CD44dbr did not enhance ability...
Side population (SP) assay identifies cells with dye/drug extrusion ability, a characteristic of stem cells. Here, we determined if SP exist in verified cell line originating from recurrent nasopharyngeal carcinoma (NPC) and xenograft established metastatic NPC. These were evaluated for stem-like properties via functional assays as well tumourigenicity. We used Hoechst 33342 to identify the non-SP (NSP) HK1 NPC xeno-284 xenograft. The assayed vitro characteristics cancer (CSC), gene...
Quantitative macro-Raman spectroscopy was applied to the analysis of bulk composition pharmaceutical drug powders. Powders were extracted from seven commercial lactose-carrier-based dry-powder inhalers: Flixotide 50, 100, 250, and 500 μg/dose (four concentrations fluticasone propionate) Seretide (three propionate, each with 50 salmeterol xinafoate ). Also, a carrier-free pressurized metered-dose inhaler same combination product, (50 μg propionate 25 per dose) tested. The applicability...
Electrostatic forces have been claimed to be a mechanism for aerosol deposition in the lungs. However, extent of its influence on performance is not clear, particularly carrier-drug formulations.To prepare lactose-salbutamol powder blends, varying blend ratio, and identify any relationships between salbutamol dose, electrostatic characteristics vitro performance.Decanted lactose micronized sulfate was mixed produce five blends (equivalent 50, 100, 200, 300 400 µg per 33 mg powder). ± 1...