A5077327741- Memory and Neural Mechanisms
- Neuroscience and Neuropharmacology Research
- Receptor Mechanisms and Signaling
- Sleep and Wakefulness Research
- Neural dynamics and brain function
Sainsbury Laboratory
2024-2025
University College London
2021-2025
Fast instinctive responses to environmental stimuli can be crucial for survival but are not always optimal. Animals adapt their behavior and suppress reactions, the neural pathways mediating such ethologically relevant forms of learning remain unclear. We found that posterolateral higher visual areas (plHVAs) escapes from innate threats through a top-down pathway ventrolateral geniculate nucleus (vLGN). plHVAs no longer necessary after learning; instead, learned relies on plasticity within...
Animals can choose to act upon, or ignore, sensory stimuli, depending on circumstance and prior knowledge. This flexibility is thought depend neural inhibition, through suppression of inappropriate disinhibition appropriate actions. Here, we identified the ventral lateral geniculate nucleus (vLGN), an inhibitory prethalamic area, as a critical node for control visually evoked defensive responses in mice. The activity vLGN projections medial superior colliculus (mSC) modulated by previous...
Fast instinctive responses to environmental stimuli can be crucial for survival, but are not always optimal. Based on prior experience, animals thus adapt their behavior and suppress reactions. However, the neural pathways mediating such ethologically relevant forms of learning remain unclear. We show that posterolateral higher visual areas (plHVAs) escapes from innate threats through a top-down pathway involving ventrolateral geniculate nucleus (vLGN). plHVAs no longer necessary after...