A5078509204- Geometric Analysis and Curvature Flows
- Nonlinear Partial Differential Equations
- Markov Chains and Monte Carlo Methods
- Stochastic processes and statistical mechanics
- Image Processing Techniques and Applications
- Industrial Vision Systems and Defect Detection
- Stochastic processes and financial applications
- AI in cancer detection
- Spectral Theory in Mathematical Physics
- Cell Image Analysis Techniques
- Advanced Mathematical Modeling in Engineering
- Numerical methods in inverse problems
- Point processes and geometric inequalities
- Hepatocellular Carcinoma Treatment and Prognosis
- Crystallization and Solubility Studies
- Image and Object Detection Techniques
- advanced mathematical theories
- X-ray Diffraction in Crystallography
- Statistical Mechanics and Entropy
- Mathematical Dynamics and Fractals
- Advanced Sensor and Control Systems
- Advanced Algorithms and Applications
- Probability and Risk Models
- Advanced Harmonic Analysis Research
- Cancer, Hypoxia, and Metabolism
Purdue University West Lafayette
2021-2025
First Affiliated Hospital of Anhui Medical University
2013-2025
Anhui Medical University
2013-2025
Zhejiang University
2010-2025
Suzhou Traditional Chinese Medicine Hospital
2024-2025
Nanjing Drum Tower Hospital
2025
Nanjing University
2025
Air Force Engineering University
2012-2024
Laboratoire de Mathématiques
2009-2024
Hangzhou First People's Hospital
2012-2024
Vascular calcification is the formation of mineralised tissue within walls arteries and associated with increased cardiovascular morbidity mortality. The pathology involves osteogenic differentiation vascular smooth muscle cells (VSMCs) matrix mineralisation. development has many similarities to bone formation; although exact mechanisms are not fully understood. Recent studies have demonstrated that bioactive sphingolipids, ceramide sphingosine-1-phosphate (S1P), regulators formation. levels...
We first give a characterization of the L1-transportation cost-information inequality on metric space and next find some appropriate sufficient condition to transportation inequalities for dependent sequences. Applications random dynamical systems diffusions are studied.
The product of the Nijmegen breakage syndrome gene (NBS1) plays crucial roles in DNA damage response through its association with many proteins, including MRE11 and RAD50. However, it remains to be determined exactly how NBS1 accumulates at or near double-strand breaks. Here we report that MDC1 directly binds targets sites damage. MDC1-NBS1 interaction occurs a specific region (residues 200-420) MDC1, which contains multiple consensus casein kinase 2 (CK2) phosphorylation sites. In addition,...
We establish a general result on the existence and uniqueness of quasi-stationary distribution \mu_{\mathcal{D}} strongly Feller Markov process (X_{t},t\ge 0) killed when it exits domain \mathcal{D} , under some Lyapunov function condition. Our covers case hypoelliptic damped Hamiltonian systems. method is based characterization essential spectral radius by means functions measures noncompactness.
This paper consists of three-parts. In the first-part, we find a common condition-the $C^2$ regularity--both for CLT and moderate deviations. We show that this condition is verified in two important situations: Lee-Yang theorem case FKG system case. second part, apply previous results to additive functionals Markov process. By means Feynman-Kac formula Kasto's analytic perturbation theory, holds under assumption 1 an isolated, simple only eigenvalue with modulus operator $P_1$ acting on...
Background Recent studies have shown that high expression levels of class I histone deacetylases (HDACs) correlate with malignant phenotype and poor prognosis in some human tumors. However, the patterns prognostic role HDAC isoforms hepatocellular carcinoma (HCC) remain unclear. Methodology/Principal Findings The clinical significance were assessed by immunohistochemistry a cohort 43 hepatitis B virus-associated HCC patients treated liver transplantation. In addition, effects inhibition on...
BACKGROUND: Ovarian cancer (OC) is the fifth most common type of in women worldwide. MiR-27a plays an important role development ovarian cancer. However, exact function and molecular mechanism miR-27a epithelial-mesenchymal transition (EMT) has not been thoroughly elucida ted to date. METHODS: Quantitative real-time PCR (qRT-PCR) was used determine expression FOXO1 mRNA tissues cells. The investigated through overexpression knockdown vitro. Wound healing Transwell assays were performed...
Abstract Deregulated glucose metabolism termed the “Warburg effect” is a fundamental feature of cancers, including colorectal cancer. This typically characterized with an increased rate glycolysis, and concomitant reduced tricarboxylic acid (TCA) cycle as compared to normal cells. How TCA manipulated in cancer cells remains unknown. Here, we show that O -linked N -acetylglucosamine (O-GlcNAc) regulates Depletion OGT, sole transferase O-GlcNAc, significantly increases Mechanistically,...
NIR (novel INHAT repressor) is a transcriptional co-repressor with inhibitor of histone acetyltransferase (INHAT) activity and has previously been shown to physically interact suppress p53 function. However, the mechanism by which suppresses not completely understood. Using proteomic approach, we have identified Aurora kinase B as novel binding partner NIR. We show that B, exist in protein complex binds NIR, thus also indirectly associates p53. Functionally, overexpression or activity,...
The primary step in tissue cytometry is the automated distinction of individual cells (segmentation). Since cell borders are seldom labeled, generally segmented by their nuclei. While tools have been developed for segmenting nuclei two dimensions, segmentation three-dimensional volumes remains a challenging task. lack effective methods represents bottleneck realization potential cytometry, particularly as clearing present opportunity to characterize entire organs. Methods based on deep...
Geometric graph is a special kind of with geometric features, which vital to model many scientific problems. Unlike generic graphs, graphs often exhibit physical symmetries translations, rotations, and reflections, making them ineffectively processed by current Graph Neural Networks (GNNs). To tackle this issue, researchers proposed variety equipped invariant/equivariant properties better characterize the geometry topology graphs. Given progress in field, it imperative conduct comprehensive...
Epstein-Barr virus (EBV)-encoded latent membrane protein 1 (LMP1) is oncogenic and indispensable for EBV-mediated B cell transformation. LMP1 capable of activating several intracellular signaling pathways including the NF-κB pathway, which contributes to Two regions in cytoplasmic carboxyl tail LMP1, namely C-terminal 2 (CTAR1 CTAR2), are responsible activation, with CTAR2 being main activator. Although CTAR1-mediated activation was previously shown be TRAF3-dependent, we showed here that...
In this paper we establish some explicit and sharp estimates of the spectral gap log-Sobolev constant for mean field particles system, uniform in number particles, when confinement potential have many local minimums. Our inequality, based on Zegarlinski's theorem Gibbs measures, allows us to obtain exponential convergence entropy McKean-Vlasov equation with an rate constant, generalizing result [10] by means displacement convexity approach, or [19, 20] Bakry-Emery technique recent [9]...
Abstract Background and Objectives Recurrence of hepatocellular carcinoma (HCC) after liver transplantation (LT) remains a major cause post‐LT death. However, currently there is still lacking the markers to reliably predict recurrence. This study was undertaken evaluate association between three polymorphisms (C1236T, G2677A/T, C3435T) Multidrug resistance 1 (MDR1) gene risk recurrence LT. Methods Genomic DNA 99 HCC patients undergoing LT extracted from peripheral blood lymphocytes...