A5000762171- 3D Printing in Biomedical Research
- Innovative Microfluidic and Catalytic Techniques Innovation
- Additive Manufacturing and 3D Printing Technologies
- Advanced Sensor and Energy Harvesting Materials
- Microfluidic and Capillary Electrophoresis Applications
- Microfluidic and Bio-sensing Technologies
- Dielectric materials and actuators
- Mechanical Circulatory Support Devices
- Electrospun Nanofibers in Biomedical Applications
- Muscle activation and electromyography studies
- Tissue Engineering and Regenerative Medicine
- Advanced MRI Techniques and Applications
- Electrowetting and Microfluidic Technologies
- Modular Robots and Swarm Intelligence
- Soft Robotics and Applications
- Nonlinear Optical Materials Studies
- Anesthesia and Sedative Agents
- Anatomy and Medical Technology
- Monoclonal and Polyclonal Antibodies Research
- Biomedical Ethics and Regulation
- Intravenous Infusion Technology and Safety
- Characterization and Applications of Magnetic Nanoparticles
- Nanofabrication and Lithography Techniques
- Olfactory and Sensory Function Studies
- Photoacoustic and Ultrasonic Imaging
Boston University
2025
Harvard University
2021-2025
Singapore University of Technology and Design
2019-2024
National University of Singapore
2019-2024
Brigham and Women's Hospital
2021-2022
Pillar (Ukraine)
2019
Recapitulation of complex tissues signifies a remarkable challenge and, to date, only few approaches have emerged that can efficiently reconstruct necessary gradients in 3D constructs. This is true even though mimicry these great importance establish the functionality engineered and devices. Here, composable-gradient Digital Light Processing (DLP)-based (bio)printing system developed, utilizing unprecedented integration microfluidic mixer for generation either continual or discrete desired...
Digital light processing bioprinting favors biofabrication of tissues with improved structural complexity. However, soft-tissue fabrication this method remains a challenge to balance the physical performances bioinks for high-fidelity and suitable microenvironments encapsulated cells thrive. Here, we propose molecular cleavage approach, where hyaluronic acid methacrylate (HAMA) is mixed gelatin methacryloyl achieve high-performance bioprinting, followed by selectively enzymatic digestion...
Abstract Flexible and stretchable antennas are important for wireless communication using wearable implantable devices to address mechanical mismatch at the tissue–device interface. Emerging technologies of liquid‐metal‐based electronics promising approaches improve flexibility stretchability conventional metal‐based antennas. However, existing methods encapsulate liquid metals require monolithically thick (at least 100 µm) substrates, resulting limited in deformability tissue‐adhesiveness....
3D printing has emerged as an enabling approach in a variety of different fields. However, the bulk volume systems limits expansion their applications. In this study, portable Digital Light Processing (DLP) printer is built based on smartphone-powered projector and custom-written smartphone-operated app. Constructs with detailed surface architectures, porous features, or hollow structures, well sophisticated tissue analogs, are successfully printed using platform, by utilizing commercial...
TapeTech is a flexible, adhesive-based microfluidic connectivity solution that streamlines fluidic integration with organ-on-a-chip devices by providing leak-proof sealing, mitigating pressure surges, and enabling rapid, cost-effective customization.
Modular multi-organ perfusion systems offer the unique opportunity to customize different physiological systemic interactions.
This paper introduces an approach to fabricating lightweight, untethered soft robots capable of diverse biomimetic locomotion. Untethering robotics from electrical or pneumatic power remains one the prominent challenges within field. The development functional robotic systems hinges heavily on mitigating their weight; however, conventional weight network actuators (pneu-nets) in has hindered operations. To address this challenge, we developed film-balloon (FiBa) modules that drastically...
Abstract Despite recent advances in biofabrication, recapitulating complex architectures of cell‐laden vascular constructs remains challenging. To date, biofabricated models have not yet realized four fundamental attributes native vasculatures simultaneously: freestanding, branching, multilayered, and perfusable. In this work, a microfluidics‐enabled molding technique combined with coaxial bioprinting to fabricate anatomically relevant, consisting hydrogels is developed. By using 3D porous...
Commercially available peristaltic pumps for microfluidics are usually bulky, expensive, and not customizable. Herein, we developed a cost-effective kit to build micro-peristaltic pump (~ 50 USD) consisting of 3D-printed off-the-shelf components. We demonstrated fabricating two variants with different sizes operating flowrates using the kit. The assembled offered flowrate 0.02 ~ 727.3 μL/min, smallest this was 20 × 28 mm. This designed modular components (i.e., each component followed...
Polysiloxane is a desirable material for the fabrication of devices in microfluidics, lab-on-a-chip, and microelectromechanical systems, but direct patterning microstructures using liquid polysiloxane resins would require adequate rheological chemical properties resins. In this work, we developed simple method to fabricate planar consisting commercially available without changing their properties. We used ink writing (DIW) printer dispense curable (with viscosity range 1–100 Pa·s) immiscible...
Adverse cutaneous reactions are potentially life-threatening skin side effects caused by drugs administered into the human body. The availability of a human-specific in vitro platform that can prospectively screen and predict this risk is therefore great importance to drug safety. However, since adverse mediated at least 2 distinct mechanisms, both involving systemic interactions between liver, immune dermal tissues, existing models have not been able comprehensively recapitulate these...
Abstract This paper describes a method for fabricating microfluidic electronics with 3D interconnected networks by direct ink writing (DIW)‐based printing. Existing printing technologies have yet to simultaneously realize 1) of multilayered microchannels without supporting materials or post‐processing and 2) integration electronic elements during the process research aims develop fabricate support‐free consisting silicone sealant collapse extruded structure while integrating fabrication DIW....
Stereolithography (SL) 3D printing has been widely applied for the fabrication of microchannels with photocurable resins and hydrogels, albeit limitations in complexity dimensions attainable due to inadvertent polymerization trapped photoresin within channel voids difficulty evacuating from channels after printing. Herein, a novel approach circumvent these by modularizing fluidic network into printable subunits assembling printed reconstruct is proposed. This validated fabricating 2D...
Flexible and stretchable radiofrequency coils for magnetic resonance imaging represent an emerging rapidly growing field. The main advantage of such coil designs is their conformal nature, enabling a closer anatomical fit, patient comfort, freedom movement. Previously, we demonstrated proof-of-concept single element design with self-tuning smart geometry. In this work, evaluate the feasibility scaling concept to multi-element array associated engineering manufacturing challenges. To goal,...
Bioprinting In article number 2107038, Yu Shrike Zhang and co-workers develop a (bio)printing system based on Digital Light Processing to utilize the integration of microfluidic mixer for generation either continual or discrete gradients desired (bio)inks in real time. As such, precisely controlled are composable on-the-fly by facilely adjusting (bio)ink flow ratios, supporting potential platform numerous biomedical applications.
Recent developments in the field of radiofrequency (RF) coils for magnetic resonance imaging (MRI) offer flexible and patient-friendly solutions. Previously, we demonstrated a proof-of-concept single-element stretchable coil design based on liquid metal self-tuning smart geometry. In this work, numerically analyze experimentally study multi-channel array demonstrate its application dynamic knee imaging. We also compare our to commonly used commercial rigid array. Our numerical analysis shows...
Stretchable receive coils can provide conformal fitting, improved SNR, and dynamic imaging capabilities. However, conductor stretching alters the resonance frequency, reducing potential SNR advantages. Previously, we proposed demonstrated in a single element prototype smart self-tuning coil design which allows to maintain desired Larmor frequency with stretching. This work investigates applicability of techniques multi-channel stretchable array demonstrates its performance silico vitro....
Abstract Recent progress in additive manufacturing has enabled the application of stereolithography (SLA) bioprinting to produce 3D biomimetic structures. Bioinks for SLA often require synthetic polymers as supplements ensure structural integrity printed cell‐laden constructs. High molecular weight (MW) poly(ethylene‐glycol)‐diacrylate (PEGDA) (MW ≥ 3400 Da) is commonly used enhance mechanical property crosslinked hydrogels. However, production bioink with high MW PEGDA requires in‐house...