A5080164748- Cancer Genomics and Diagnostics
- Cancer Cells and Metastasis
- Mass Spectrometry Techniques and Applications
- Prostate Cancer Treatment and Research
- 3D Printing in Biomedical Research
- Microfluidic and Bio-sensing Technologies
- Pluripotent Stem Cells Research
- Cellular Mechanics and Interactions
- Lung Cancer Treatments and Mutations
- Medical Imaging and Pathology Studies
University of Wisconsin–Madison
2013-2020
University of Wisconsin Carbone Cancer Center
2017-2019
Wisconsin Institutes for Discovery
2013
Abstract Purpose: There is a critical clinical need for new predictive and pharmacodynamic biomarkers that evaluate pathway activity in patients treated with targeted therapies. A microscale platform known as VERSA (versatile exclusion-based rare sample analysis) was developed to integrate readouts across protein, mRNA, DNA circulating tumor cells (CTC) comprehensive analysis of the androgen receptor (AR) signaling pathway. Experimental Design: Utilizing preparation principles, handheld chip...
Lung cancer is the leading cause of cancer-related deaths in United States and worldwide. This has led to major research initiatives focusing on improving early diagnosis rate, as well development pharmacodynamic biomarkers. However, broad clinical integration these approaches limited due invasive nature lung biopsies, needle aspirates resections. Recently, an advance for sampling suspicious nodules collect mini-bronchoalveolar lavage (mBAL) samples was shown be diagnostically relevant but...
Abstract Concentration gradients of biochemical stimuli such as morphogens play a critical role in directing cell fate patterning across species and throughout development but are not commonly recapitulated vitro . While biomolecule have been generated using customized microfluidic platforms, broad implementation has limited because these platforms introduce new variables to culture externally driven flow, specialized matrix, or extended time for situ long range diffusion. Here we method...
Comprehensive analysis of tumor heterogeneity requires robust methods for the isolation and single cells from patient samples. An ideal approach would be fully compatible with downstream analytic methods, such as advanced genomic testing. These endpoints necessitate use live at high purity. A multitude microfluidic circulating cell (CTC) enrichment technologies exist, but many those perform bulk sample are not, on their own, capable single-cell interrogation. To address this, we developed an...
Although average survival rates for lung cancer have improved, earlier and better diagnosis remains a priority. One promising approach to assisting safer of lesions is bronchoalveolar lavage (BAL), which provides sample tissue as well proteins immune cells from the vicinity lesion, yet diagnostic sensitivity challenge. Reproducible isolation epithelia multianalyte extraction potential improve provide new information developing personalized therapeutic approaches. We present use recently...
<div>Abstract<p><b>Purpose:</b> There is a critical clinical need for new predictive and pharmacodynamic biomarkers that evaluate pathway activity in patients treated with targeted therapies. A microscale platform known as VERSA (versatile exclusion-based rare sample analysis) was developed to integrate readouts across protein, mRNA, DNA circulating tumor cells (CTC) comprehensive analysis of the androgen receptor (AR) signaling...
<div>Abstract<p><b>Purpose:</b> There is a critical clinical need for new predictive and pharmacodynamic biomarkers that evaluate pathway activity in patients treated with targeted therapies. A microscale platform known as VERSA (versatile exclusion-based rare sample analysis) was developed to integrate readouts across protein, mRNA, DNA circulating tumor cells (CTC) comprehensive analysis of the androgen receptor (AR) signaling...