A5101450764- Microfluidic and Bio-sensing Technologies
- Micro and Nano Robotics
- Electrowetting and Microfluidic Technologies
- Orbital Angular Momentum in Optics
- Modular Robots and Swarm Intelligence
- Soft Robotics and Applications
- Microfluidic and Capillary Electrophoresis Applications
- Molecular Communication and Nanonetworks
- Innovative Microfluidic and Catalytic Techniques Innovation
- Microbial Inactivation Methods
- Advanced Materials and Mechanics
- 3D Printing in Biomedical Research
- Cancer Cells and Metastasis
- Central Venous Catheters and Hemodialysis
- Shoulder Injury and Treatment
- Coronary Interventions and Diagnostics
- Spine and Intervertebral Disc Pathology
- Bone Metabolism and Diseases
- Vascular Procedures and Complications
- Robotic Path Planning Algorithms
- Characterization and Applications of Magnetic Nanoparticles
- Graphene and Nanomaterials Applications
- Nanoparticle-Based Drug Delivery
- Control and Dynamics of Mobile Robots
- Bone health and osteoporosis research
The University of Tokyo
2024-2025
Beihang University
2017-2024
Institute of Electrical and Electronics Engineers
2023
Field‐controlled micro–nano manipulations and robots have attracted increasing attention in the fields of medicine, environment, engineering, energy due to their outstanding characteristics which include small size, strong controllability, cluster action, penetrability; thus, they gradually become an important research focus manufacturing vivo detection. However, precise control, targeted drug delivery vivo, cellular operation remain challenges. Herein, scientific results produced recent...
Abstract Border‐nearing microrobots with self‐propelling and navigating capabilities have promising applications in micromanipulation bioengineering, because they can stimulate the surrounding fluid flow for object transportation. However, ensuring biosafety of is a concurrent challenge bioengineering applications. Here, macrophage template‐based (cell robots) that be controlled individually or chain‐like swarms are proposed, which transport various objects. The cell robots constructed using...
Abstract Single‐cell arrays have emerged as a versatile method for executing single‐cell manipulations across an array of biological applications. In this paper, innovative microfluidic platform is unveiled that utilizes optoelectronic tweezers (OETs) to and sort individual cells at flow rate 20 µL min −1 . This also adept dielectrophoresis (DEP)‐based, light‐guided retrievals from designated micro‐wells. presents compelling non‐contact the rapid straightforward sorting are hard distinguish....
The capability to precisely rotate cells and other micrometer-sized biological samples is invaluable in biomedicine, bioengineering, biophysics. We propose herein a novel on-chip cell rotation method using acoustic microstreaming generated by oscillating asymmetrical microstructures. When the vibration applied microchip with our custom-designed microstructures, two different modes of highly localized microvortices are that utilized achieve in-plane out-of-plane rotational manipulation...
Anticipating tumor metastasis by circulating cells captured acoustic microstreaming.
Flexible magnetic small‐scale robots (overall dimensions smaller than 1 cm) can use a patterned magnetization profile to noninvasively access confined, enclosed liquid environment and therefore achieve applications in object manipulation or minimally invasive procedures. Existing magnetic‐controlled have shown wide usage for their high mobility higher degrees of freedom rigid counterparts. Herein, an octopus‐like soft robot is proposed potential biomedical engineering fields. First, control...
Non-contact manipulation technology has a wide range of applications in the and fabrication micro/nanomaterials. However, devices are often complex, operated only by professionals, limited single function. Here, we propose simple versatile optoelectronic tweezer (OET) system that can be easily controlled for manipulating microparticles with different sizes. In this work, designed established an system. The OET could used to manipulate particles sizes from 2 μm 150 μm. also micro-objects...
Endovascular guidewire interventional surgery is an effective treatment for vascular diseases. However, due to factors, such as blood viscosity and complex morphology, the interfered by strong varying resistance when moving in lesion’s vasculature. This greatly affects efficiency safety of clinical operation. Here, we develop a novel system that applies ultrasonic micro-amplitude vibration conventional passive studying drag reduction effect under multiple factors. The mainly composed...
Abstract Manipulation of single cells or particles is crucial in the biomedical field. However, precisely and rapidly manipulating without damaging them a significant challenge. In this study, novel strategy for indirect manipulation microparticles that can satisfy these requirements via combination particle‐induced dielectrophoretic forces (PiDEP) optoelectronic tweezers (OET) developed. This based primarily on principle experiencing same tend to repel each other, whereas those different...
The importance of cell manipulation and cultivation is increasing rapidly in various fields, such as drug discovery, regenerative medicine, investigation new energy sources. This paper presents a method to transport cells microfluidic chip without contact. A local vortex was generated when high-frequency oscillation microtool induced chip. controlled by tuning the tool's parameters, amplitude frequency. were then transported based on direction movement, their position, posture, trajectories...
The miniature soft robots have many promising applications, including micro-manipulations, endoscopy, and microsurgery, etc. Nevertheless, it remains challenging to fabricate a miniatured robot device that is thin, flexible, can perform multimodal locomotor mobility with sensory capacity. In this study, we propose miniatured, multi-layer (two shape memory polymer layers, flexible copper heater, silk particle enhanced actuator layer, layer) four-limb (0.45-gram, 35mm-long, 12 mm-wide) total...
Interaction between micro-objects is used to achieve the trapping, transport, and release of particles in OET, enhancing high-throughput transportation, also assemble some special microparticles structures.
Micro-spiral has a wide range of applications in smart materials, such as drug delivery, deformable and micro-scale electronic devices by utilizing the manipulation electric fields, magnetic flow fields. However, it is incredibly challenging to achieve massively parallel micro-spiral form particular microstructure these conventional methods. Here, simple method reported for assembling micro-spirals into various microstructures
Loading individual oocytes is a critical step for injecting RNA, expressing heterologous proteins, performing electrophysiological measurements, and so on. However, existing methods remain challenge automatically loading multiple single into different locations. Herein, novel microfluidic chip on robotic manipulator (chip‐on‐robot) with feedback control flexible manipulation of within large spatial range proposed. The controls the to reach locations based imaging feedback. then utilizes...
Guidewires for endovascular interventional surgery are inevitably affected by high frictional resistance because of direct contact with the vascular wall, which greatly reduces operation efficiency and safety. This article presents a method applying radial ultrasonic microvibration at proximal end conventional passive guidewire to reduce resistance. The proposed theoretically reduced reducing friction coefficient, actual area, net time between wall. effectiveness was experimentally...
Magnetic driving is an excellent non-contact method that can penetrate through the human and biological tissues without any damage. Also, micro-nano robots are expected to enter into body, which will bring about revolutionary development in robotics. Here we propose octopus-like soft robot be used biomedical engineering fields future. Firstly, establish a magnetic control system, uses minimum number of coils. The system respond quickly with high precision propel 3D space utilizing coupled...
Magnetically Actuated Millirobots In article number 1900148, Lin Feng and co-workers present an octopus-like soft robot which can move freely in 3D workspace without constraints. A magnetic control system using the minimum of coils, is inspired by regular tetrahedron structure, designed to propel robot.
Abstract The responsive color‐changing bionic skin imitation of certain organisms such as chameleons has potential applications in the fields chemical sensing and information transfer. Inspired by cellular structure chameleon iridophores, a flexible scalable fabrication strategy was proposed present study, which centers on modular assembly miniature pixel dots. dots were formed self‐assembling charged silica particles inside hydrogels fabricated bulk using microfluidic methods. immobilized...
In this paper, we present a magnetized cell-robot using macrophages as templates, which can be controlled under strong gradient magnetic field, to approach and kill cancer cells in both vitro vivo environment. Firstly, establish control system only four coils generate field up 4.14 T/m utilizing the coupled contributed by multiple electromagnets acting concert. Most importantly, is based on macrophage proposed, transported vicinity of precisely field. Then will actively phagocytose...
Micromanipulation In article number 2105414, Xue Bai, Lin Feng, and co-workers develop a magnetically actuated cell-robot system for micromanipulation. The robots exhibit high position control accuracy generate flow field that can be used to transport microspheres cells using an external rotating magnetic field. cell also form chain-like swarms large object.
A deep learning-assisted automated separation platform of single cells and microparticles using optoelectronic tweezers was proposed in this paper, which allows accurate manipulation long-term dynamic observation without complex microfluidic structures. single-cell detector based on YOLOv5 developed to realize automation high throughput recognition chips. Then these recognized or particles were captured operated by the light patterns generated system. We built a realized automatic queuing...
Optoelectronic Tweezers In article number 2307329, Lin Feng and co-workers constructed a novel microfluidic chip based on an optoelectronic tweezers system, comprising micro-well array integrated with photo-conductive plate. This method enables the parallel capture of cells, forming effective cell arrays in continuous flow. It also allows for light-guided single-cell retrievals by modulating electric field generating negative dielectrophoresis force target micro-well.