Ketoconazole (KET), an imidazole derivative with well-known antifungal properties, is lipophilic and practically insoluble in water, therefore its clinical use has some practical disadvantages. The aim of the present study was to investigate influence PAMAM-NH(2) PAMAM-OH dendrimers generation 2 3 on solubility activity KET design evaluate hydrogel PAMAM dendrimers. It shown that surface charge strongly affects their improvement KET. MIC MFC values obtained by broth dilution method indicate...

Sodium alginate and its oligosaccharides through potential antifungal properties might improve the activity of drugs enhancing their efficacy potentially reducing frequency application. Mucoadhesive buccal films are oral dosage forms designed for maintaining both local or systemic drug effects seem to be a very promising alternative conventional formulations. Hence, in this study, mucoadhesive based on oligosaccharide oligomer composed predominantly mannuronic acid administration...

Periodontal diseases are some of the most widespread oral afflictions, and they labeled as chronic infections caused by accumulation bacteria in dental plaque that produces localized inflammation periodontium. The use local drug delivery systems to treat periodontal has received greater attention, because active substance is targeted directly affected area, which minimizes its systemic side effects. Therefore, purpose investigation was develop characterize different types gel...

Buccal films are recognized as easily applicable, microbiologically stable drug dosage forms with good retentivity at the mucosa intended for therapy of oromucosal conditions, especially infectious diseases. Multilayer composed layers oppositely charged polymers separated by ionically interacting polymeric chains creating polyelectrolyte complexes represent very interesting and relatively poorly explored area. We aimed to develop antifungal multilayer systems cationic chitosan anionic pectin...

Candida species are opportunistic fungi, which primary causative agents of vulvovaginal candidiasis. The cure candidiasis is difficult, lengthy, and associated with the fungi resistivity. Therefore, research for novel active substances unconventional drug delivery systems providing effective safe treatment still an subject. Microparticles, as multicompartment dosage forms due to larger areas, provide short passage diffusion, might improve therapeutic efficiency. Sodium alginate a natural...

Erythromycin (EM) and tobramycin (TOB) are well-known widely used antibiotics, belonging to different therapeutic groups: macrolide aminoglycoside, respectively. Moreover, they possess solubility: EM is slightly soluble TOB freely in water. It was previously demonstrated that PAMAM dendrimers enhanced the pharmacological activity of antifungal drugs by increasing their solubility. Therefore, it appears interesting investigate effect PAMAM-NH2 PAMAM-OH generation 2 (G2) 3 (G3) on...

Atorvastatin calcium, an antifungal agent, has the potential to be repositioned/repurposed combat increasing antimicrobial resistance. However, one of most crucial issues in developing atorvastatin calcium-loaded products with a topical effect is achieving optimal release and dissolution rates this statin produce desired therapeutic effect. In paper, we report on development pharmaceutical assessment hydrogels composed low-molecular-weight chitosan, tragacanth, xanthan...

Secnidazole is a second generation 5-nitroimidazole with high potential for application in anaerobic periodontal infections therapy. In this study, the process of developing drug-loaded films composed oppositely charged chitosan and pectin intra-pocket administration presented. Due to limitations layer-by-layer technique receiving systems type, which resulted from spontaneous crystallization secnidazole at stage drying, new preparation method was developed. For purpose, drug...

Periodontitis consists a group of dental disorders that affect about 70 % the world population. The therapy mainly relies on mechanical removing bacterial biofilm, nevertheless, local or systemic antibacterial agents play key role in treating acute conditions. Secnidazole is newer derivative commonly used metronidazole with high safety profile and broad spectrum antimicrobial activity. aim study was to evaluate applicability polyelectrolyte complex-based hydrogels composed anionic tragacanth...

Evaluation of cationic polyamidoamine dendrimers’ dermal toxicity in the rat skin model Katarzyna Winnicka,1 Magdalena Wroblewska,1 Sosnowska,1 Halina Car,2 Irena Kasacka3 1Department Pharmaceutical Technology, Faculty Pharmacy, Medical University Bialystok, Poland; 2Department Experimental Pharmacology, Health Sciences, 3Department Histology and Cytophysiology, Poland Abstract: Polyamidoamine (PAMAM) dendrimers are multi-branched, three-dimensional polymers with unique architecture,...

Alginate microspheres with metformin hydrochloride were prepared by the spray drying method in order to improve residence time of drug stomach. Nine formulations (F1–F9) various : polymer ratio (1 2, 1 1, and 2 1) different sodium alginate concentration (1%, 2%, 3%) evaluated for size, morphology, loading, Zeta potential, swelling degree. In vitro release, mathematical release profile, physical state also evaluated. Optimal formulation characterized highest loading was F6 (drug 2% solution)....

The genus Bidens L. (Asteraceae) refers to several species of plants used in traditional phytotherapeutic preparations. B. tripartita, also known as bur marigold, is the most familiar plant and has been a remedy for chronic dysentery. hydrodistilled essential oil aerial parts Polish tripartita was analyzed using gas chromatography (GC) chromatography-mass spectrometry (GC-MS) techniques. To exclude any potential toxic effects on human dermal fibroblasts, MTT test (methyl thiazolyl...

Fungal skin infections are currently a major clinical problem due to their increased occurrence and drug resistance. The treatment of fungal is based on monotherapy or polytherapy using the synergy therapeutic substances. Tea tree oil (TTO) may be valuable addition traditional antifungal drugs its anti-inflammatory activity. Ketoconazole (KTZ) an imidazole agent commonly used as for dermatological infections. use hydrogels organogel-based formulations has been increasing past few years, easy...

Polyamidoamine dendrimers (PAMAM) represent a new class of hyperbranched, monodisperse, three-dimensional polymers with unique properties, which make them very promising carriers antimicrobial agents. The present study aimed to evaluate the influence PAMAM-NH2 generation two (G2) or three (G3) on physicochemical characteristics and structure hydrogels model antibacterial lipophilic drug—erythromycin—commonly used in topical applications. From obtained rheograms, it can be concluded that...

Hydrogels are semi-solid systems with high flexibility, which, due to holding large amounts of water, similar natural tissues and very useful in the field biomedical applications. Despite wide range polymers available form hydrogels, novel techniques utilized obtain hydrogels adequate properties still being developed. The aim this study was evaluate impact freeze-thaw technique on cryogels based sodium alginate chitosan glutamate posaconazole as a model antifungal substance. effect freezing...

Fungal infections and invasive mycoses, despite the continuous medicine progress, are an important globally therapeutic problem. Multicompartment dosage formulations (e.g., microparticles) ensure a short drug diffusion way high surface area of release, which as consequence can provide improvement efficiency compared to traditional forms. As fucoidan is promising component with wide biological activity per se, aim this study was prepare fucospheres (fucoidan fucoidan/gelatin microparticles...

The preparation technology and the optimal composition of hydrogels with sulfur prepared using various types polymers – hydroxyethyl cellulose (HEC), Carbopol 980, sodium alginate have been developed. Designed were evaluated microscopically, for pH, viscosity mechanical parameters. In addition, ex vivo bioadhesive properties obtained hairless mice skin model as adhesive layer estimated. Hydrogels based on possessed most favorable application stable at different temperature humidity...

The aim of this study was to develop eye-drops with cefuroxime (CEF) sodium or vancomycin (VAN) hydrochloride, antibiotics that are instable in water. Anhydrous self-emulsifying oils (SEO) proposed as a carrier and suspended. In the contact tear fluid, formulation should transform into emulsion, fast dissolution an antibiotic. CEF VAN (5% w/w) suspended SEO carriers prepared by dissolving surfactants (Tween 20 Span 80 5% Miglyol, castor oil, olive oil. Formulations without citrate (2% were...

This work investigates the possibility of using thiolated silicone oils as new components in protective creams and their impact on efficacy these products. Thiolated were synthesized by amide bond formation between primary amino groups poly17dimethylsiloxane-co-(3-aminopropyl)-methylsiloxane] carboxylic thiol ligand (3-mercaptopropionic acid) with carbodiimide a coupling agent. To evaluate compare properties kinds thiomers, three different emulsion o/w types obtained. Emulsion E1 contained...

The frequent occurrence of bacterial skin infections makes it necessary to search new solutions. Due the limited effectiveness traditional antibacterial agents, novel treatment alternatives are investigated. use plant origin compounds seems be beneficial, because they usually well tolerated and do not cause as many side effects synthetic substances. Tea tree oil (TTO) is noted for well-established antimicrobial activity, so can used in various diseases. It effective against Gram-negative...

Because hyaluronic acid (HA) cosmetic gels are the most commonly used in industry, purpose of this study was to develop a new gel formulation HA carboxymethyl cellulose sodium (Carmellose, CMC Na), prepared three different ways and characterize obtained terms texture, pH, thixotropy decide which preparation method is optimal for obtaining gel. The formulations were by dispersing Na water glycerol mixing it with (at same time, after gelling 24 h preparation). rheological properties texture...

Xerosis is one of the common dermatological problems. Preparations recommended for daily care dry skin are emollients. Emollient preparations demonstrate a moisturizing effect, they soften and smoothen skin, keep water in epidermis, supplement lipids upper layers protect from external harmful agents. The purpose this study was to develop characterize emollients containing natural emulsifier Olivem 1000 as topical delivery systems urea or sodium hialuronate. Physicochemical mechanical...