During the last few decades, use of ultrasonography for detection fetal abnormalities has become widespread in many industrialised countries. This resulted a shift timing diagnosis congenital infants from neonatal period to prenatal period. major implications both clinicians and couples involved. In case ultrasound anomaly there are several options obstetric management, ranging standard care non-aggressive termination pregnancy. essay explores context clinical parental decision-making after...

Abstract Background Unplanned or unintended pregnancies form a major public health concern because they are associated with unfavorable birth outcomes as well social adversity, stress and depression among parents-to-be. Several risk factors for unplanned in women have previously been identified, but studies usually take unidimensional approach by focusing on only one few factors, disregarding the possibility that predictors might cluster. Furthermore, data men largely overlooked. The purpose...

Patient-reported outcome measures (PROMs) and patient-reported experience (PREMs) can highlight issues that remain unnoticed when using standard clinical quality indicators. However, estimations of the potential power measuring PROMs PREMs to identify unrecognised areas suitable for improvement are often limited by a lack reliable real-world data. Here, we report on how indicator set was recently developed International Consortium Health Outcome Measures change perspectives assessment in...

Objectives Contraception remains a key topic in societal and political debates. Since most research focuses on female adolescents, there is gap understanding adult perspectives sex differences contraceptive responsibility, satisfaction, knowledge. Theater-based research, which fosters engagement open discussions, offers novel approach to exploring these while also enhancing awareness. This study explores adults' views using theater-based approach, examining Study Design Conducted at...

Lithium is often continued during pregnancy to reduce the risk of perinatal mood episodes for women with bipolar disorder. However, little known about effect intrauterine lithium exposure on brain development. The aim this study was investigate structure in children after lithium.Participants were offspring, aged 8-14 years, a diagnosis spectrum In total, 63 participated study: 30 and 33 without lithium. Global volume outcomes white matter integrity assessed using structural MRI diffusion...

Psychosocial risk factors are frequently present in pregnant women and associated with adverse maternal neonatal outcomes. Professional guidelines recommend early detection of vulnerability provision multidisciplinary care, including an integrated care plan for social factors, such as residing deprived areas, teenage pregnancy, psychiatric illness. However, to date, approach is impeded by lack data on co-occurrence vulnerability. Therefore, we aim describe illness, or substance use during...

ABSTRACT Background Much research has focused on identifying predictors of late antenatal care initiation. Many these (e.g., young age, migration background, socioeconomic position) are impossible to modify, illustrating the need explore other interventions. Objectives This study aims investigate inequalities in initiation and assess whether early pregnancy recognition may reduce inequalities. Methods Data from Generation R were used ( N = 4196), a population‐based birth cohort Rotterdam,...

BACKGROUND: The endocannabinoid system (ECS) plays an important role in the early stages of pregnancy, while cannabis use during pregnancy associates with a greater risk preeclampsia. This study quantified placental ECS component mRNA levels gestational age-matched healthy pregnant women, women preeclampsia, and who used throughout their pregnancy. Next, it compared effects endogenous agonists anandamide 2-arachidonoylglycerol those cannabinoid receptor type 1 2 HU-210 HU-308 chorionic plate...

Dysregulation of the hypothalamic-pituitary-adrenal (HPA) axis has been linked to peripartum depression, potentially contributing symptom persistence. This study examines relationship between cortisol awakening response (CAR) during pregnancy and depressive reduction postpartum. Pregnant women with a current episode were included in this study, part larger RCT on bright light therapy. At baseline (12-32 weeks pregnancy), participants provided saliva samples at awakening, +30, +60 min...

Depression during pregnancy is a common and high impact disease. Generally, 5–10 % of pregnant women suffer from depression. Children who have been exposed to maternal depression higher risk adverse birth outcomes more often show cognitive, emotional behavioural problems. Therefore, early detection treatment antepartum necessary. Both psychotherapy antidepressant medication, first choice treatments in non-pregnant population, limitations treating pregnancy. it urgent relevant investigate...

Objectives Approximately 11%–13% of pregnant women suffer from depression. Bright light therapy (BLT) is a promising treatment, combining direct availability, sufficient efficacy, low costs and high safety for both mother child. Here, we examined the effects BLT on depression during pregnancy. Design Randomised, double-blind controlled trial. Setting Primary secondary care in The Netherlands, November 2016 to March 2019. Participants 67 (12–32 weeks gestational age) with DSM-5 diagnosis...

Abstract Objectives Lithium is an effective treatment for bipolar disorder, also during pregnancy to prevent the recurrence of episodes in perinatal period. Little known about neuropsychological development lithium‐exposed offspring. The current study was designed investigate functioning children with aim provide further knowledge on long‐term effects lithium use pregnancy. Methods Participants were offspring women a diagnosis spectrum aged 6–14 years. In total, 99 participated study, 56...

Maternity care increasingly focuses on evaluating psychosocial vulnerability during pregnancy. Research and nationwide (public health) programs, both in the USA Europe, led to development of new protocols screening instruments for providers systematically screen pregnant women. However, standardised is complex since it requires discussion sensitive issues. Women may fear stigmatisation have limited trust their or health system. Our study contributes growing field client-facing risk work by...

Abstract Background Alcohol consumption during pregnancy is associated with major birth defects and developmental disabilities. Questionnaires concerning alcohol underestimate use while the of a reliable objective biomarker for enables more accurate screening. Phosphatidylethanol can detect low levels in previous two weeks. In this study we aimed to biochemically assess prevalence early using phosphatidylethanol blood compare self-reported consumption. Methods To evaluate assessed levels,...

Abstract Introduction Lithium use during pregnancy reduces the risk of mood episodes in perinatal period for women with bipolar disorder. Some previous studies found deleterious effects intrauterine lithium exposure on birth outcomes, yet little is known about a dose response relationship. The current study investigated influence maternal serum levels outcomes. Methods This retrospective observational cohort included spectrum disorder who were referred to specialized psychiatric and...

Background: Lithium is an effective treatment in pregnancy and postpartum for the prevention of relapse bipolar disorder, but there a lack knowledge about potential adverse impact on fetal development. Aims: To investigate lithium exposure early growth. Methods: In this retrospective observational cohort study, we included all singleton pregnancies women using referred advanced ultrasound scanning between 1994 2018 to University Medical Centers Leiden Rotterdam, Netherlands ( n=119). The...

The purpose of this study is to describe the implementation and outcomes an Eye Movement Desensitization Reprocessing (EMDR) treatment-program for women with posttraumatic stress disorder (PTSD) after childbirth.

Antipsychotics are increasingly prescribed in pregnancy, yet little is known about potential long-term developmental effects on children. In this study, we investigated the effect of prenatal antipsychotic exposure neurodevelopmental functioning school-aged children.We performed a cross-sectional assessment 91 children aged 6-14 years whose mothers had severe mental illness and were either exposed or unexposed to medication during pregnancy. Neurodevelopmental outcomes assessed using...