A5040017557- Vector-borne infectious diseases
- Viral Infections and Vectors
- Insect and Pesticide Research
- Toxin Mechanisms and Immunotoxins
- Malaria Research and Control
- Antimicrobial Peptides and Activities
- Mosquito-borne diseases and control
- Peptidase Inhibition and Analysis
- Catalytic Processes in Materials Science
- Machine Learning in Bioinformatics
- Vector-Borne Animal Diseases
- Toxoplasma gondii Research Studies
- vaccines and immunoinformatics approaches
- Catalysis and Oxidation Reactions
- Advanced Proteomics Techniques and Applications
- Mass Spectrometry Techniques and Applications
- Hepatitis B Virus Studies
- Heat shock proteins research
- Essential Oils and Antimicrobial Activity
- Autophagy in Disease and Therapy
- Biochemical and Structural Characterization
- Cytomegalovirus and herpesvirus research
Université de Strasbourg
2016-2024
Centre National de la Recherche Scientifique
2016-2024
Institut Pluridisciplinaire Hubert Curien
2015-2017
Membrane trafficking pathways play critical roles in Apicomplexa, a phylum of protozoan parasites that cause life-threatening diseases worldwide. Here we report the first retromer-trafficking interactome Toxoplasma gondii. This retromer complex includes trimer Vps35-Vps26-Vps29 core serves as hub for endosome-like compartment and parasite-specific proteins. Conditional ablation TgVps35 reveals is crucial biogenesis secretory organelles maintaining parasite morphology. We identify TgHP12...
Abstract Plasmodium falciparum extensively modifies its chosen host cell, the mature human erythrocyte. This remodelling is carried out by parasite-encoded proteins that are exported into cell. To gain access to red blood these must cross parasitophorous vacuole, a membrane bound compartment surrounding parasite generated during invasion process. Many carry so-called PEXEL/HT signal directs their transport. We recently reported unexpected finding of species-restricted Hsp70, termed PfHsp70x,...
In vector-borne diseases, the skin plays an essential role in transmission of pathogens between vertebrate host and blood-feeding arthropods pathogen persistence. Borrelia burgdorferi sensu lato is a tick-borne bacterium that causes Lyme borreliosis (LB) humans. This may establish long-lasting infection its natural where it can persist some other organs. Using mouse model, we demonstrate targets regardless route inoculation, there at low densities are difficult to detect via qPCR, but were...
Lyme disease is the most important vector-borne in Northern hemisphere and represents a major public health challenge with insufficient means of reliable diagnosis. Skin rarely investigated proteomics but constitutes case key interface where pathogens can enter, persist, multiply. Therefore, we on skin samples to detect Borrelia proteins directly cutaneous biopsies robust specific way. We first set up discovery gel prefractionation-LC-MS/MS approach murine model infected by burgdorferi sensu...
Abstract The excessive use of antifungal agents, compounded by the shortage new drugs being introduced into market, is causing accumulation multi-resistance phenotypes in many fungal strains. Consequently, alternative molecules to conventional agents are urgently needed prevent emergence resistance. In this context, Cateslytin (Ctl), a natural peptide derived from processing Chromogranin A, has already been described as an effective antimicrobial agent against several pathogens including...
Tick-borne diseases affecting humans and animals are on the rise worldwide. Vaccines constitute an effective control measure, but very few available. We selected Lyme borreliosis, a bacterial infection transmitted by hard tick Ixodes, to validate new concept identify vaccine candidates. This disease is most common tick-borne in Northern Hemisphere. Although attempts develop exist, none have been successfully marketed. In diseases, skin constitutes specific environment encountered pathogen...