A5025976446- DNA Repair Mechanisms
- PARP inhibition in cancer therapy
- DNA and Nucleic Acid Chemistry
- Acute Myeloid Leukemia Research
- Cancer therapeutics and mechanisms
- Migraine and Headache Studies
- Protein Degradation and Inhibitors
- Histone Deacetylase Inhibitors Research
- Effects and risks of endocrine disrupting chemicals
- Cancer-related Molecular Pathways
- Genomics, phytochemicals, and oxidative stress
- Photodynamic Therapy Research Studies
- Pharmaceutical and Antibiotic Environmental Impacts
- Trigeminal Neuralgia and Treatments
- Plant Genetic and Mutation Studies
- Cardiovascular Syncope and Autonomic Disorders
- CRISPR and Genetic Engineering
- Waste Management and Environmental Impact
- Neurological Complications and Syndromes
- Chromatography in Natural Products
- Agriculture, Plant Science, Crop Management
- Neurological Disorders and Treatments
- Carcinogens and Genotoxicity Assessment
- Toxic Organic Pollutants Impact
- Endodontics and Root Canal Treatments
University of Łódź
2017-2024
Temple University
2022-2023
Medical University of Lodz
2022
Adam Mickiewicz University in Poznań
2021
Poznan University of Medical Sciences
2016
Niepubliczna Wyższa Szkoła Medyczna
2003
Akademia Muzyczna im. Ignacego Jana Paderewskiego w Poznaniu
1991
The inhibition of histone deacetylases (HDACs) holds promise as a potential anti-cancer therapy and non-histone protein acetylation is frequently disrupted in cancer, leading to cancer initiation progression. Additionally, the use deacetylase inhibitor (HDACi) such class I HDAC inhibitor—valproic acid (VPA) has been shown enhance effectiveness DNA-damaging factors, cisplatin or radiation. In this study, we found that VPA combination with talazoparib (BMN-673—PARP1 inhibitor—PARPi) and/or...
DNA polymerase theta (Polθ, encoded by POLQ gene) plays an essential role in Polθ-mediated end-joining (TMEJ) of double-strand breaks (DSB). Inhibition Polθ is synthetic lethal homologous recombination (HR)-deficient tumor cells. However, DSBs can be also repaired PARP1 and RAD52-mediated mechanisms. Because leukemia cells accumulate spontaneous DSBs, we tested if simultaneous targeting or RAD52 enhance the effect HR-deficient Transformation potential oncogenes inducing BRCA1/2-deficiency...
Cancer cells often accumulate spontaneous and treatment-induced DNA damage i.e. potentially lethal double strand breaks (DSBs). Targeting DSB repair mechanisms with specific inhibitors could sensitize cancer to the toxic effect of DSBs. Current treatment for glioblastoma includes tumor resection followed by radiotherapy and/or temozolomide (TMZ) - an alkylating agent inducing damage. We hypothesize that combination PARP inhibitor (PARPi) TMZ in displaying downregulation genes trigger...
HDAC inhibitors (HDACi) hold great potential as anticancer therapies due to their ability regulate the acetylation of both histone and non-histone proteins, which is frequently disrupted in cancer contributes development advancement disease. Additionally, HDACi have been shown enhance cytotoxic effects DNA-damaging agents such radiation cisplatin. In this study, we found that deacetylase inhibits valproic acid (VPA), synergized with PARP1 inhibitor (PARPi), talazoparib (BMN-673), alkylating...
DNA repair proteins became the popular targets in research on cancer treatment. In our studies we hypothesized that inhibition of polymerase theta (Polθ) and its combination with Poly (ADP-ribose) 1 (PARP1) or RAD52 alkylating drug temozolomide (TMZ) has an anticancer effect glioblastoma cells (GBM21), whereas it a low impact normal human astrocytes (NHA). The compounds was assessed by analysis cell viability, apoptosis, proliferation, damage cycle distribution, as well gene expression. main...
<p>S2. Phenotype of Polq-/-;Parp1-/- and Polq-/-;Rad52-/- mice.</p>
<p>S1. Genetic aberrations and mRNA expression variabilities of POLQ, PARP1 RAD52 do not coexist in 519 AML samples from the BEAT-AML cohort.</p>
<p>S5. Targeting Polθ + PARP1 and RAD52 induced dual synthetic lethality against HR-deficient leukemia cells.</p>
<p>S4. Targeting Polθ + PARP and RAD52 induced dual synthetic lethality against HR -deficient MPN cells.</p>
<p>S3. Simultaneous inhibition of Polθ helicase and DNA polymerase activity exerted synergistic effect against RAD54-/- leukemia cells.</p>
<div>Abstract<p>DNA polymerase theta (Poltheta, encoded by POLQ gene) plays an essential role in Poltheta-mediated end-joining (TMEJ) of DNA double-strand breaks (DSBs). Inhibition Poltheta is synthetic lethal homologous recombination (HR)-deficient tumor cells. However, DSBs can be also repaired PARP1 and RAD52 -mediated mechanisms. Since leukemia cells accumulate spontaneous DSBs, we tested if simultaneous targeting Pol or enhance the effect HR-deficient Transformation...
<p>S4. Targeting Polθ + PARP and RAD52 induced dual synthetic lethality against HR -deficient MPN cells.</p>
<p>S3. Simultaneous inhibition of Polθ helicase and DNA polymerase activity exerted synergistic effect against RAD54-/- leukemia cells.</p>
<p>S1. Genetic aberrations and mRNA expression variabilities of POLQ, PARP1 RAD52 do not coexist in 519 AML samples from the BEAT-AML cohort.</p>
<p>S5. Targeting Polθ + PARP1 and RAD52 induced dual synthetic lethality against HR-deficient leukemia cells.</p>
<p>S2. Phenotype of Polq-/-;Parp1-/- and Polq-/-;Rad52-/- mice.</p>
Aim. Ischemia‑modified albumin (IMA) is a marker of myocardial ischemia and may be affected by occurring in other tissues. Migraine has been reported as risk factor ischemic stroke or cardiovascular events. Dysfunction endothelial cells, well association with arteriopathies was evidenced migraine patients. The aim this study to evaluate interictal IMA patients.Material Methods. Fifty migraineurs aged 38 ± 9 years were included the study. control group consisted 25 healthy volunteers 37 8...
Aim. Ischemia-modified albumin (IMA) is a marker of myocardial ischemia and may be affected by occurring in other tissues. Migraine has been reported as risk factor ischemic stroke or cardiovascular events. Dysfunction endothelial cells, well association with arteriopathies was evidenced migraine patients. The aim this study to evaluate interictal IMA patients.Material Methods. Fifty migraineurs aged 38 ± 9 years were included the study. control group consisted 25 healthy volunteers 37 8...