A5082327411- Antifungal resistance and susceptibility
- Antibiotics Pharmacokinetics and Efficacy
- Antibiotic Resistance in Bacteria
- Cancer Treatment and Pharmacology
- Cancer-related Molecular Pathways
- Intensive Care Unit Cognitive Disorders
- Fungal Infections and Studies
- 14-3-3 protein interactions
- Pneumocystis jirovecii pneumonia detection and treatment
- Mycobacterium research and diagnosis
- Biosimilars and Bioanalytical Methods
- Statistical Methods in Clinical Trials
Freie Universität Berlin
2019-2024
Universität Greifswald
2016
Drug approval is based on exposure, response, and variability of studied populations, typically excluding comorbidities/medications very ill patients, thus not representing real-world populations. This results in wide therapeutic outcome for individual patients. Model-informed precision dosing (MIPD) can characterize/quantify this variability, support optimal dose selection, enable individualized therapy. The aim perspective to raise awareness MIPD, identify challenges hindering its...
Model-informed precision dosing (MIPD) frequently uses nonlinear mixed-effects (NLME) models to predict and optimize therapy outcomes based on patient characteristics therapeutic drug monitoring data. MIPD is indicated for compounds with narrow range complex pharmacokinetics (PK), such as voriconazole, a broad-spectrum antifungal prevention treatment of invasive fungal infections. To provide guidance recommendations evidence-based application this work aimed (i) externally evaluate compare...
Voriconazole (VRC), a broad-spectrum antifungal drug, exhibits nonlinear pharmacokinetics (PK) due to saturable metabolic processes, autoinhibition and metabolite-mediated inhibition on their own formation. VRC PK is also characterised by high inter- intraindividual variability, primarily associated with cytochrome P450 (CYP) 2C19 genetic polymorphism. Additionally, recent in vitro findings indicate that main metabolites, voriconazole N-oxide (NO) hydroxyvoriconazole (OHVRC), inhibit CYP...
Abstract The non-receptor tyrosine kinase Brk (breast tumor kinase, PTK-6) has been linked to various effects in cells including cell proliferation, differentiation and migration. Modulation of cellular signaling occurs due protein scaffolding substrate phosphorylation, while depend on type molecular context. Recent findings suggest, that some hallmark cancer may be the active whereas inactive seems involved different physiological processes epithelial cells. Novel α-carboline derivatives...