A5001387943- Corneal Surgery and Treatments
- Liver physiology and pathology
- Ocular Surface and Contact Lens
- Drug-Induced Hepatotoxicity and Protection
- Corneal surgery and disorders
- Pluripotent Stem Cells Research
- Tissue Engineering and Regenerative Medicine
- Liver Disease Diagnosis and Treatment
- Mesenchymal stem cell research
- Glaucoma and retinal disorders
Medical University of Silesia
2021-2025
Abstract Limbal stem cells deficiency (LSCD) is an eye disease caused by the loss of in corneal limbus as a succession injury due physical, biological, or chemical agents. Current therapies LSCD are focused on transplantation donor corneas tissue equivalents produced from autologous limbal cells. Every year there waiting millions patients for cornea all over world and list growing to relatively low number donors. On other hand, into recipient’s body associated with higher risk possible side...
Background and Aims: Experimental models using carbon tetrachloride (CCl4) D-galactosamine (D-GalN) can be used in preclinical assessment of acute liver failure (ALF) therapies. Unfortunately, these are characterized by different dynamics injury depending on the animal strain, administered hepatotoxin, its dose. The aim this study was to compare known rat mouse ALF with a view their future introduction into cell therapy experiments. In particular, based histopathological molecular changes,...
Abstract In animal experimental models the administration of stem cells into spleen should ensure high effectiveness their implantation in liver due to a direct vascular connection between two organs. The aim this study was update methods intrasplenic cell transplantation using human amniotic epithelial (hAECs) which are promising treatment diseases. BALB/c mice were administered intrasplenically with 0.5, 1, and 2 million hAECs by bolus injection (400 µl/min) via subcutaneous splenic port...
Background: In humans, chronic liver disease (CLD) is a serious clinical condition with many life-threatening complications. Currently, there no therapy to stop or slow down the progression of fibrosis. Experimental mouse models CLD, induced by repeated intraperitoneal injections carbon tetrachloride (CCL4) and D-galactosamine (D-GalN), can be used evaluate therapies that cannot performed in humans. A major drawback these animal different dynamics fibrosis depending on strain, administered...
Abstract Limbal stem cells deficiency (LSCD) is an eye disease caused by the loss of in corneal limbus as a succession injury due physical, biological, or chemical agents. Current therapies LSCD are focused on transplantation donor corneas tissue equivalents produced from autologous limbal cells. Every year there waiting millions people for cornea all over world and list patients growing to relatively low number donors. On other hand, into recipient’s body associated with higher risk...