A5086841102- Ovarian cancer diagnosis and treatment
- Pelvic floor disorders treatments
- Cervical Cancer and HPV Research
- Meta-analysis and systematic reviews
- Endometrial and Cervical Cancer Treatments
- BRCA gene mutations in cancer
- Anorectal Disease Treatments and Outcomes
- Ovarian function and disorders
- Parkinson's Disease Mechanisms and Treatments
- Colorectal and Anal Carcinomas
- Pelvic and Acetabular Injuries
- Mental Health Research Topics
- Prenatal Screening and Diagnostics
- Reproductive Biology and Fertility
- Health Systems, Economic Evaluations, Quality of Life
- Osteoarthritis Treatment and Mechanisms
- Hernia repair and management
- Genital Health and Disease
- Endometriosis Research and Treatment
- Advanced Statistical Modeling Techniques
- Neurobiology and Insect Physiology Research
- Reproductive Health and Technologies
- Pregnancy and preeclampsia studies
- Statistical Methods and Applications
- Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
Radboud University Nijmegen
2016-2025
Radboud University Medical Center
2016-2025
University Medical Center
2014-2025
TropIQ Health Sciences
2024-2025
Catharina Ziekenhuis
2017-2023
Maastricht University
2023
Radboud Institute for Molecular Life Sciences
2017-2020
Roche (Switzerland)
2017
MSD K.K. (Japan)
2017
University Hospital and Clinics
2017
The DerSimonian and Laird approach (DL) is widely used for random effects meta-analysis, but this often results in inappropriate type I error rates. method described by Hartung, Knapp, Sidik Jonkman (HKSJ) known to perform better when trials of similar size are combined. However evidence realistic situations, where one trial might be much larger than the other trials, lacking. We aimed evaluate relative performance DL HKSJ methods studies different sizes combined develop a simple convert...
Meta-analyses are increasingly used for synthesis of evidence from biomedical research, and often include an assessment publication bias based on visual or analytical detection asymmetry in funnel plots. We studied the influence different normalisation approaches, sample size intervention effects plot asymmetry, using empirical datasets illustrative simulations. found that plots Standardized Mean Difference (SMD) plotted against standard error (SE) susceptible to distortion, leading...
To compare menopause-related quality of life (QoL) after risk-reducing salpingectomy (RRS) versus salpingo-oophorectomy (RRSO) until 3 years post-surgery. A prospective study (TUBA study) with treatment allocation based on patients' preference. Data were collected pre-surgery and at months, 1 Multicentre preference trial in thirteen hospitals the Netherlands. BRCA1/2 pathogenic variant (PV) carriers aged 25-40 (BRCA1) or 25-45 (BRCA2), who premenopausal, without a future child wish current...
<b>Objective</b> To investigate whether uterus preserving vaginal sacrospinous hysteropexy is non-inferior to hysterectomy with suspension of the uterosacral ligaments in surgical treatment uterine prolapse. <b>Design</b> Multicentre randomised controlled non-blinded non-inferiority trial. <b>Setting</b> 4 non-university teaching hospitals, Netherlands. <b>Participants</b> 208 healthy women prolapse stage 2 or higher requiring surgery and no history pelvic floor surgery. <b>Interventions</b>...
Background. Immunization of healthy volunteers by bites from Plasmodium falciparum–infected mosquitoes during chloroquine chemoprophylaxis (hereafter, and sporozoites [CPS] immunization) induces sterile protection against malaria. CPS-induced is mediated immunity pre-erythrocytic stages, presumably at least partially cytotoxic cellular responses. We therefore aimed to investigate the association T-cell markers with protection. Methods. In a double-blind randomized controlled trial, we...
Our understanding of the etiology, pathophysiology, phenotypic diversity, and progression Parkinson's disease has stagnated. Consequently, patients do not receive best care, leading to unnecessary disability, mounting costs for society. The Personalized Parkinson Project (PPP) proposes an unbiased approach biomarker development with multiple biomarkers measured longitudinally. main aims are: (a) perform a set hypothesis-driven analyses on comprehensive dataset, correlating established novel...
To evaluate the effectiveness and success of uterus preserving sacrospinous hysteropexy as an alternative to vaginal hysterectomy with uterosacral ligament suspension in surgical treatment uterine prolapse five years after surgery.Observational follow-up SAVE U (sacrospinous fixation versus ≥2) randomised controlled trial.Four non-university teaching hospitals, Netherlands.204 208 healthy women initial trial (2009-12) stage 2 or higher requiring surgery no history pelvic floor who had been...
How do female patients experience fertility preservation (FP) consultation (FPC) with a specialist in reproductive medicine and subsequent decision-making on FP? Most had positive experiences FPC, but negative were found to be associated decisional conflict decision regret. When confronted need for gonadotoxic treatment, girls young women will have make an irreversible regard FP. Patients may develop regret about their during follow-up. Patients' opportunities ask questions FPC knowledge FP...
Purpose The aim of this study was to determine the risk human papillomavirus (HPV)–related carcinomas and premalignancies in women diagnosed with cervical intraepithelial neoplasia grade 3 (CIN3). Knowledge is important preventing development progression other HPV-related carcinomas, by considering prophylactic HPV vaccination and/or paying increased attention when CIN3 identified. Methods Women a between 1990 2010 were identified from Dutch nationwide registry histopathology cytopathology...
In 2017 the cervical cancer screening program in The Netherlands will be revised. Cervical smears primarily tested for presence of high-risk human papillomavirus (hrHPV) instead cytology, and vaginal self-sampling offered to non-responders. This includes a potential risk that part women who would otherwise opt smear wait self-sampling. However, hrHPV responder population has never been studied yet. aim this study was investigate applicability accuracy detecting population. A total 2049...
We determined whether the participation rate for a brush-based cervicovaginal self-sampling device is noninferior to lavage-based one testing hrHPV (high-risk human papillomavirus). Additionally, positivity rates hrHPV, detection cervical intraepithelial neoplasia grades 2 and 3 or worse (CIN2+/3+), user comfort were compared. A total of 35,477 non-responders regular screening program aged 33-63 years invited participate. Eligible women (n = 30,130) randomly assigned receive either device,...
Randomized trials typically estimate average relative treatment effects, but decisions on the benefit of a are possibly better informed by more individualized predictions absolute effect. In case binary outcome, these effect require knowledge individual's risk without and incorporation differential (ie, varying with patient characteristics). this article, we lay out causal structure in terms potential outcomes describe required assumptions that underlie interpretation its prediction....
Most women with a BRCA1/2 pathogenic variant undergo premature menopause potential short- and long-term morbidity due to the current method of ovarian carcinoma prevention: risk-reducing salpingo-oophorectomy (RRSO). Because fallopian tubes play key role in cancer pathogenesis, salpingectomy delayed oophorectomy may be novel strategy benefits delaying menopause.To compare menopause-related quality life after (RRS) RRSO carriers variant.A multicenter nonrandomized controlled preference trial...