A5073898407- dental development and anomalies
- Cleft Lip and Palate Research
- Oral and Maxillofacial Pathology
- Craniofacial Disorders and Treatments
- Dental materials and restorations
- Dental Radiography and Imaging
- Congenital Ear and Nasal Anomalies
- Orthodontics and Dentofacial Orthopedics
- Dental Trauma and Treatments
- Forensic Anthropology and Bioarchaeology Studies
- Bone and Dental Protein Studies
- Cancer-related gene regulation
- Temporomandibular Joint Disorders
- Engineering Technology and Methodologies
- Additive Manufacturing and 3D Printing Technologies
- Genomic variations and chromosomal abnormalities
- Dental Research and COVID-19
- Autopsy Techniques and Outcomes
- Lymphoma Diagnosis and Treatment
- Suicide and Self-Harm Studies
- Endodontics and Root Canal Treatments
- Mental Health Treatment and Access
- Laser Applications in Dentistry and Medicine
- Musculoskeletal synovial abnormalities and treatments
- Biochemical and Structural Characterization
Poznan University of Medical Sciences
2016-2025
Cleft lip with or without cleft palate (CL/P) is one of the most common craniofacial malformations, a complex and multifactorial etiology. Because genetic heterogeneity facial clefts, aim this study was to investigate contribution previously reported candidate genes chromosomal loci risk CL/P in Polish population.We performed an analysis 18 polymorphisms FOXE1, IRF6, MSX1, PAX9, TBX10, FGF10, FGFR1, TGFalpha, TGFbeta3, SUMO1, region 8q24 group 175 patients properly matched control...
Tooth agenesis is one of the most common dental anomalies, with a complex and not yet fully elucidated aetiology. Given crucial role Wnt signalling pathway during tooth development, purpose this study was to determine whether nucleotide variants genes encoding components might be associated hypodontia oligodontia in Polish population. A set 34 single polymorphism ( SNPs ) 13 WNT WNT‐related were analyzed group 157 patients properly matched control n = 430). In addition, direct sequencing...
Dental age is one of the most reliable methods for determining a patient's age. The timing teething, period tooth replacement, or degree attrition an important diagnostic factor in assessment individual's developmental It used orthodontics, pediatric dentistry, endocrinology, forensic medicine, and pathomorphology, but also scenarios regarding international adoptions illegal immigrants. to date are time-consuming not very precise. For this reason, artificial intelligence increasingly...
Orthodontic retention is the final important stage of orthodontic treatment, aim which to consolidate functional and aesthetic position teeth. Among adults, fixed retainers made different types wires are most common. The this study was analyse mechanical properties a new generation retainers—printed by 3D printers. Materials Methods: conducted using samples Nextdent MFH C&B N1 resin in form cuboid bars with nominal dimensions width b = 3 mm, thickness d 0.8 mm; 1 1.2 length l 30 mm for...
(1) Background: Modern imaging methods and constantly developing technologies extend the range of diagnostic tools in medicine orthodontics. Thanks to them, scientists doctors can use devices designed diagnose 3D structures human body. The aim study was assess usefulness digital orthodontic models as a tool work an orthodontist through comparative analysis value measurements made on traditional plaster virtual models. (2) Methods: A total 80 sets were made, including 40 48 parameters...
Tooth development is regulated through a series of reciprocal interactions between the dental epithelium and mesenchyme requires protein products number genes. It has been reported that selective tooth agenesis associated with mutations in human MSX PAX9 Mutational analysis two genes was performed 25 individuals familial or sporadic form permanent agenesis. Single‐stranded conformational polymorphism revealed no entire coding sequence MSX1 gene. In , novel, heterozygous G151A transition...
Mostowska A, Hozyasz KK, Biedziak B, Wojcicka P, Lianeri M, Jagodzinski PP. Genotype and haplotype analysis of WNT genes in non‐syndromic cleft lip with or without palate. Eur J Oral Sci 2012; 120: 1–8. © 2012 The wingless‐type MMTV integration site family (Wnt) signalling pathway plays a crucial role craniofacial development. Recently, nucleotide variants have been shown to be associated oral congenital anomalies, including facial clefts. Therefore, the current study we decided assay...
Non-syndromic cleft lip with or without palate (nsCL/P) is a common craniofacial anomaly complex and heterogeneous aetiology. Knowledge regarding specific genetic factors underlying this birth defect still not well understood. Therefore, we conducted an independent replication analysis for the top-associated variants located within DLG1 locus at chromosome 3q29, which was identified as novel cleft-susceptibility in our genome-wide association study (GWAS). Mega-analysis of pooled individual...
The analog methods used in the clinical assessment of patient’s chronological age are subjective and characterized by low accuracy. When using those methods, there is a noticeable discrepancy between estimated based on relevant scientific studies. Innovations field information technology increasingly medicine, with particular emphasis artificial intelligence methods. paper presents research aimed at developing new, effective methodology for modern IT In this paper, study was conducted to...
Non-syndromic cleft lip and palate (CLP) is one of the most common birth defects. Recent genome-wide association studies (GWAS) have identified several novel risk loci associated with this craniofacial anomaly. Therefore, objective report was to investigate contribution top seven polymorphisms reaching statistical significance in GWAS analyses Polish population.Nucleotide variants located at chromosomal regions 1p22.1, 10q25.3, 17q22, 20q12 were tested a group 206 patients nonsyndromic CLP...
With easy-to-process 3D printing materials and fast production, the quality of dental services can be improved. In conventional procedure, dentist makes temporary crowns directly in patient’s mouth, e.g., from most commonly used bis-acrylic composites. Temporary made office without use CAD/CAM are often inferior quality, which results impaired hygiene, poorer masticatory mechanics, greater deposition plaque, calculus sediment, may adversely affect periodontal gum health. The mechanical...
Non-syndromic tooth agenesis (ns-TA) is one of the most common dental anomalies characterized by congenital absence at least permanent (excluding third molars). Regarding essential role genetic factors in ns-TA aetiology, present study aimed to identify novel pathogenic variants underlying hypodontia and oligodontia. In a group 65 patients 127 healthy individuals from genetically homogenous Polish population, coding sequences 423 candidate genes were screened using targeted next-generation...
Background: Clinical success depends on the contact strength and wear resistance of medical devices made polymer materials. The scientific goal resulted from problem using different methods surface evaluation materials used in production orthodontic appliances. purpose work was an experimental comparative assessment indentation hardness scratch sliding four selected polymeric manufacture Methods: Four commercial were compared. Shore tests a test with Rockwell indenter performed. A performed...
Mostowska A, Hozyasz KK, Biedziak B, Misiak J, Jagodzinski PP. Polymorphisms located in the region containing BHMT and BHMT2 genes as maternal protective factors for orofacial clefts. Eur J Oral Sci 2010; 118: 325–332. © 2010 The Authors. Journal compilation Nonsyndromic cleft lip with or without palate (NCL/P) is one of most common craniofacial malformations; however, its aetiology still unclear. Because effects nutrition on fetal development are well known, we decided to pursue question...
Congenital maxillary lateral incisor agenesis ( MLIA ) is one of the most common subtypes dental agenesis. Because little known with regard to aetiology this anomaly, aim study was determine contribution nucleotide variants in wingless‐type MMTV integration site family, member 10A WNT ), msh homeobox 1 MSX and paired box 9 PAX risk a Polish population. Coding regions selected genes were analysed by direct sequencing group 20 individuals unilateral bilateral , associated or not other...
Background. The loss of physical properties orthodontic chains has been a topic discussion among scientists and clinicians, motivating efforts to improve elastic materials minimize the decrease force. Orthodontic companies have introduced memory elastomers, which, according manufacturers, improved mechanical properties.Objectives. aim study was evaluate effects stretching elastomeric submerged in 37°C artificial saliva.Material Methods. assessed 2 types chains. first phase evaluated 1)...
The cosmetic and pharmaceutical industry is constantly on the lookout for new efficient active substances. In this article, we focus resveratrol, an substance with beneficial health properties, which obtained, among others, from vines knotweed (Reynoutria japonica). study, assessed level of skin hydration in a group probands who used cream or without resveratrol. compound has been shown to have moisturizing tightening improving overall condition skin.
Determining the chronological age of children or adolescents is becoming an extremely necessary and important issue. Correct age-assessment methods are especially in process international adoption case immigrants without valid documents confirming their identity. It well known that traditional, analog widely used clinical evaluation burdened with a high error rate characterized by low accuracy. On other hand, new digital approaches appear medicine more often, which allow increase accuracy...
Non-syndromic cleft palate (ns-CP) has a genetically heterogeneous aetiology. Numerous studies have suggested crucial role of rare coding variants in characterizing the unrevealed component genetic variation ns-CP called "missing heritability". Therefore, this study aimed to detect low-frequency that are implicated aetiology Polish population. For purpose, regions 423 genes associated with orofacial anomalies and/or involved facial development were screened 38 patients using next-generation...