A5042337895- Advanced Neuroimaging Techniques and Applications
- Functional Brain Connectivity Studies
- Advanced MRI Techniques and Applications
- Schizophrenia research and treatment
- Tryptophan and brain disorders
- Neural dynamics and brain function
- Radiomics and Machine Learning in Medical Imaging
- Atrial Fibrillation Management and Outcomes
- Stress Responses and Cortisol
- Radiation Dose and Imaging
- Advanced X-ray and CT Imaging
- Glaucoma and retinal disorders
- Brain Metastases and Treatment
- Acute Ischemic Stroke Management
- Cardiac electrophysiology and arrhythmias
- Lung Cancer Research Studies
- Ferroptosis and cancer prognosis
- Colorectal Cancer Surgical Treatments
- Iron Metabolism and Disorders
- Folate and B Vitamins Research
- Neuroscience of respiration and sleep
- AI in cancer detection
- Genetic Associations and Epidemiology
- Phytochemistry and biological activity of medicinal plants
- Connexins and lens biology
Sichuan University
2010-2025
West China Hospital of Sichuan University
2010-2025
Fujian Medical University
2025
Chengdu Military General Hospital
2013-2024
Chinese Academy of Medical Sciences & Peking Union Medical College
2018-2024
University of Cincinnati
2023-2024
Jingzhou Central Hospital
2020
Yangtze University
2020
Peking Union Medical College Hospital
2018
First Affiliated Hospital of Xinjiang Medical University
2013
Abstract Though gray matter deficits have been consistently revealed in chronic treated schizophrenia, it is still not clear whether there are different brain alterations between never and patients. To explore the patterns of among patients those with monotherapy, we recruited 35 never-treated schizophrenia illness durations ranging from 5 to 48 years, 20 duration-matched risperidone monotherapy clozapine patients, 55 healthy controls. GM (surface area, cortical thickness, volume) measures...
Abstract Investigation of the choroid plexus in schizophrenia has seen growing interest due to its role interaction between neuroinflammation and brain dysfunction. Most previous studies included treated long-term ill patients, while antipsychotics illness course might both affect plexus. Here, we recruited first-episode antipsychotic-naïve performed high-resolution structural scan manually extracted volume. Choroid volume was compared patients healthy controls after controlling for age, sex...
Dietary capsaicin plays a protective role in hypertension, atherosclerosis, obesity, and hyperlipidemia through activating the transient receptor potential vanilloid type 1 (TRPV1), nonselective cation channel. This study was designed to investigate of cardiac hypertrophy fibrosis pressure overload model. TRPV1 knockout (KO) mice their wild-type (WT) littermates, aged 8 weeks, were randomly divided into sham aortic banding surgery groups fed with chow or plus for 10 weeks. significantly...
Despite observational studies linking brain iron levels to psychiatric disorders, the exact causal relationship remains poorly understood. This study aims examine between in specific subcortical regions and risk of disorders. Utilizing two-sample Mendelian randomization (MR) analysis, this investigates associations level changes 16 nuclei eight major including schizophrenia (SCZ), depressive disorder (MDD), autism spectrum disorders (ASD), attention-deficit/hyperactivity disorder, bipolar...
Objectives: To investigate the correlation between iron deposition changes in lesioned thalamic nuclei and presence severity of central post-stroke pain (CPSP) after infarction using quantitative susceptibility mapping (QSM) technique. Methods: We consecutively enrolled patients with unilateral chronic radiological examination conformed . Detailed multidimensional characteristics measured as follows: Douleur Neuropathique 4 (DN4) questionnaire for validation neuropathic diagnosis, Short-Form...
Background: Occurrence of post-stroke apathy (PSA) is associated with worse outcomes and poorer quality life. Particularly, post-thalamic stroke was repeatedly reported. In this study, we performed disconnection-based analyses to reveal the neural basis from both focal network perspectives. Method: This study recruited first-ever unilateral thalamic ischemic patients. The Lille Apathy Rating Scale used characterize appearance severity apathy. Patient’s lesion masks were embedded into...
Abstract INTRODUCTION Regional brain iron dyshomeostasis is observed in cerebral small vessel disease (cSVD) and other neurodegeneration processes. However, its spatial patterns, cognitive impact, underlying pathological mechanisms remain unclear. METHODS Voxel‐based analysis of quantitative susceptibility mapping (QSM) was used to detect regional changes, their correlations with function were assessed using linear regression. We combined the microarray dataset from Allen Human Brain Atlas...
Massive hepatectomy associated with infection induces liver dysfunction, or even multiple organ failure and death. Glycyrrhizin has been shown to exhibit anti-oxidant anti-inflammatory activities. The aim of the present study was investigate whether glycyrrhizin could attenuate endotoxin-induced acute injury after partial hepatectomy. Male Wistar rats (6 8 weeks old, weighing 200-250 g) were randomly assigned three groups 24 each: sham, saline glycyrrhizin. Rats injected intravenously...
Ablation of uncoupling protein 2 (UCP2) has been involved in the enhancement salt sensitivity associated with increased superoxide level and decreased nitric oxide (NO) bioavailability. However, role overexpression UCP2 salt-induced vascular dysfunction remains elusive. transgenic (TG) wild-type (WT) mice were placed on either a normal-salt (NS, 0.5%) or high-salt (HS, 8%) diet for 12 weeks. Blood pressure (BP) hypotensive responses measured, tone, level, NO bioavailability aortas measured...
Difficulties in detecting brain lesions acute ischemic stroke (AIS) have convinced researchers to use computed tomography (CT) scan for and magnetic resonance imaging (MRI) search these lesions. This work aimed develop a generative adversarial network (GAN) model CT-to-MR image synthesis evaluate reader performance with synthetic MRI (syn-MRI) suspected patients.Patients primarily AIS were randomly assigned the training (n=140) or testing (n=53) set. Emergency CT follow-up MR images set used...
Abstract Background and objective Neuro‐ophthalmologic symptoms retinal changes have been increasingly observed following thalamic stroke, there is mounting evidence indicating distinct alterations occurring in the vision‐related functional network. However, intrinsic correlations between these are not yet fully understood. Our was to explore altered patterns of network connectivity retina parameters, their with visual performance patients stroke. Methods We utilized resting‐state MRI obtain...
The aim of this study was to evaluate the effects atorvastatin on left atrial (LA) function in paroxysmal fibrillation patients.Fifty-eight patients were divided into two groups (treatment and control groups).The echocardiography parameters, including LA active emptying volume (LAAEV), fraction, maximum volume, total ejection force (LAEF), measured before treatment, then 12 18 months after treatment.Compared pre-treatment levels, parameters reflecting pump function, such as LAAEV LAEF,...
Convergent evidence is increasing to indicate progressive brain abnormalities in schizophrenia. Knowing the network features over illness course schizophrenia, independent of effects antipsychotic medications, would extend our sight on this question.We recruited 237 antipsychotic-naive patients with schizophrenia range from 16 73 years old, and 254 healthy controls. High-resolution T1 weighted images were obtained a 3.0T MR scanner. Grey matter networks constructed individually based...
Type B lactic acidosis associated with malignancies is a rare but life‑threatening complication, particularly in hematological cancers less commonly solid tumors. The current study presents case of type 59‑year‑old woman metastatic cervical neuroendocrine carcinoma (NEC), highly malignant and uncommon tumor. patient exhibited severe symptoms, including significant ascites, tachycardia hyperlactatemia, lactate levels peaking at 11.2 mM. Despite initial symptomatic treatments such as fluid...
Abstract Background Recent neuroimaging studies revealed dysregulated neurodevelopmental, or/and neurodegenerative trajectories of both structural and functional connections in schizophrenia. However, how the alterations brain’s connectivity lead to dynamic function changes schizophrenia with age remains poorly understood. Methods Combining magnetic resonance imaging a network control theory approach, white matter controllability metric (average controllability) was mapped from 16 60 years...
Abstract Background Schizophrenia is considered to be a disorder of dysconnectivity characterized by abnormal functional integration between distinct brain regions. Different connection abnormalities were found correlated with various clinical manifestations, but whether common deficit in connectivity (FC) relation both symptoms and cognitive impairments could present first-episode patients who have never received any medication remains elusive. Objective To find core the connectome that...
Abstract Understanding how structural connectivity alterations affect aberrant dynamic function using network control theory will provide new mechanistic insights into the pathophysiology of schizophrenia. The study included 140 drug-naive schizophrenia patients and 119 healthy controls (HCs). average controllability (AC) quantifying capacity brain regions/networks to shift system easy-to-reach states was calculated based on white matter compared between HCs as well functional topological...