A5102930497- Lipid Membrane Structure and Behavior
- Adipokines, Inflammation, and Metabolic Diseases
- Coronary Interventions and Diagnostics
- Acute Myocardial Infarction Research
- Antimicrobial Peptides and Activities
- Liver Disease Diagnosis and Treatment
- Cardiovascular Function and Risk Factors
- Cardiac Imaging and Diagnostics
- Peroxisome Proliferator-Activated Receptors
- Vascular Procedures and Complications
- Alcohol Consumption and Health Effects
- Cardiovascular Disease and Adiposity
- Venous Thromboembolism Diagnosis and Management
- Dialysis and Renal Disease Management
- Advanced Glycation End Products research
- Antiplatelet Therapy and Cardiovascular Diseases
- Spectroscopy and Quantum Chemical Studies
- Atherosclerosis and Cardiovascular Diseases
- Fibroblast Growth Factor Research
- Cardiac electrophysiology and arrhythmias
- Biochemical and Structural Characterization
- Protein Structure and Dynamics
- Blood Pressure and Hypertension Studies
- Cardiovascular Effects of Exercise
- Inflammatory Biomarkers in Disease Prognosis
R.O.C Military Academy
2012-2024
E-Da Hospital
2013-2023
I-Shou University
2014-2023
Chinese People's Liberation Army
2013-2020
Institute of Cardiology
2016
National Central University
1997-2011
National Defense University
2010
Kaohsiung Chang Gung Memorial Hospital
2001-2007
Chang Gung Memorial Hospital
2003-2006
Memorial Hospital of South Bend
2003-2006
Melittin is a prototype of the ubiquitous antimicrobial peptides that induce pores in membranes. It commonly used as molecular device for membrane permeabilization. Even at concentrations nanomolar range, melittin can transient allow transmembrane conduction atomic ions but not leakage glucose or larger molecules. At micromolar concentrations, induces stable allowing molecules up to tens kilodaltons, corresponding its activities. Despite extensive studies, aspects mechanism pore formation...
How antimicrobial peptides form pores in membranes is of interest as a fundamental membrane process. However, the underlying molecular mechanism, which has potential applications therapeutics, nonviral gene transfer, and drug delivery, been dispute. We have resolved this mechanism by observing time-dependent process pore formation individual giant unilamellar vesicles (GUVs) exposed to melittin solution. An GUV first expanded its surface area at constant volume then suddenly reversed...
Epicardial adipose tissue (EAT) is a part of visceral fat deposited around the heart between pericardium and myocardium along distribution coronary arteries. EAT thickness reported to be associated with atherosclerosis; however, no study has measured volume in patients type 2 diabetes or investigate its association artery disease.A hospital-based case control study.A total 49 mellitus (T2DM) 78 nondiabetic controls were studied.Cardiac multislice computed tomography was used measure volume,...
Patients with a history of cardiovascular disease are at high risk developing secondary major adverse cardiac events (MACE). This study aimed to identify independent predictors MACE after hospital admission which could be used high-risk patients who may benefit from preventive strategies. included 1,520 consecutive coronary artery (CAD) (654 acute syndrome (ACS) and 866 elective percutaneous intervention (PCI) patients) received PCI and/or stenting. was defined as all-cause mortality or...
Background: Diabetes mellitus is the leading cause of diabetic nephropathy and a major public health issue worldwide.Approximately 20-30% patients with type 2 diabetes (T2DM) have renal impairment.Fatty acid-binding protein 1 (FABP1) expressed in proximal tubule cells released into urine response to hypoxia caused by decreased peritubular capillary blood flow, FABP2 responsible for transport free fatty acids intestinal endothelium cells.There increasing evidence that FABP1 FABP play role...
The Review of Diabetic Studies,2010,7,4,275-284.DOI:10.1900/RDS.2010.7.275Published:February 2011Type:Original ArticleAuthors:Cheng-An Chiu, Li-Fen Lu, Teng-Hung Yu, Wei-Chin Hung, Fu-Mei Chung, I-Ting Tsai, Chih-Ying Yang, Chia-Chang Hsu, Yung-Chuan Chao-Ping Wang, and Yau-Jiunn Lee Author(s) affiliations:Cheng-An Chiu1, Lu2, Yu1, Hung1, Chung1, Tsai3, Yang3, Hsu4, Lu5, Wang1,6, Lee7 1Division Cardiology, 2Division Cardiac Surgery, Department 3Department Emergency, 4Division...
Secreted frizzled-related protein 5 (Sfrp5), an endogenous inhibitor of wingless-type MMTV integration site family (Wnt) signalling, is anti-inflammatory adipokine whose expression perturbed in models obesity and type 2 diabetes mellitus (T2DM). Wnt member 5a (Wnt5a) a representative ligand, recent reports suggest that Wnt5a involved inflammatory diseases metabolic disorders. The aim this study was to investigate whether plasma Sfrp5 levels are altered patients with T2DM.Plasma...
Indoxyl sulfate (IS) is linked to endothelial damage, NF-κB activation and induced development of atherosclerosis. The purpose this study was investigate the relationship between serum IS levels severity coronary artery stenosis. In addition, among various cardiovascular risk factors also explored.Serum concentrations were measured using ultra performance liquid chromatography in 191 consecutive patients presenting with stable angina. associations angiographic indexes number diseased...
Background: Fatty acid-binding protein 1 (FABP1) (also known as liver-type fatty or LFABP) is a that mainly expressed in the liver, and associated with hepatocyte injury acute transplant rejection. Reduced levels of FABP1 mice livers have been shown to be effective against nonalcoholic liver disease (NAFLD). In this study, we investigated association between plasma NAFLD patients type 2 diabetes mellitus (T2DM). Methods: We enrolled 267 T2DM patients. Clinical biochemical parameters were...
We reexamine a critical phenomenon of phospholipids in lamellar phases. The question is, Is the anomalous divergence repeat spacing near main transition result water layer or lipid bilayer? X-ray diffraction DLPC lamellae was measured partially dehydrated conditions. Its behavior is much more pronounced than previously studied DMPC. bilayer thickness calculated from conditions and then extrapolated to full hydration. results show that primarily due expansion.