A5089867206- Cancer, Hypoxia, and Metabolism
- Ultrasound and Hyperthermia Applications
- Nanoplatforms for cancer theranostics
- Obesity, Physical Activity, Diet
- Food Security and Health in Diverse Populations
- Erythropoietin and Anemia Treatment
- Photoacoustic and Ultrasonic Imaging
- Breastfeeding Practices and Influences
- Advanced Radiotherapy Techniques
- Child Nutrition and Feeding Issues
- Microfluidic and Bio-sensing Technologies
- 3D Printing in Biomedical Research
- Spectroscopy Techniques in Biomedical and Chemical Research
- Cancer, Lipids, and Metabolism
- Wound Healing and Treatments
- Infant Nutrition and Health
- Diabetic Foot Ulcer Assessment and Management
- Photodynamic Therapy Research Studies
- Helicobacter pylori-related gastroenterology studies
- Hepatocellular Carcinoma Treatment and Prognosis
- School Health and Nursing Education
- Erythrocyte Function and Pathophysiology
- Health and Lifestyle Studies
- Sarcoma Diagnosis and Treatment
- Radiation Therapy and Dosimetry
Croydon University Hospital
2021-2024
Michigan State University
2011-2021
Western Michigan University
2017
Boston Children's Hospital
2006
Johannes Gutenberg University Mainz
1994-2004
Molecular Medicine Ireland
2004
Trinity College Dublin
2004
KU Leuven
2003
St. James's Hospital
1993-1994
The University of Western Australia
1991
Although the Internet has become an important avenue for disseminating health information, theory-driven strategies aiding individuals in changing or managing behaviors are lacking. The eHealth Behavior Management Model combines Transtheoretical Model, behavioral intent aspect of Theory Planned Behavior, and persuasive communication to assist negotiating Web toward stage-specific information. It is here - at point information that moving more active stages change occurs. applied three...
Abstract Ten patients with liver metastases from primary tumors in the colorectum were treated selective internal radiation (SIR) therapy. This involved embolisation of yttrium‐90‐containing microspheres into hepatic artery at time laparotomy. The concentrated microvasculature tumour nodules by concurrent administration angiotensin II. dose being delivered to parenchyma was measured operation use an intraoperative detection probe. All nine whom preoperative carcinoembryonic antigen (CEA)...
ABSTRACT BACKGROUND Schools can promote healthy eating in adolescents. This study used a qualitative approach to examine barriers and facilitators schools. METHODS Case studies were conducted with 8 low‐income Michigan middle Interviews 1 administrator, the food service director, member of coordinated school health team at each school. RESULTS Barriers included budgetary constraints leading low prioritization initiatives; availability unhealthy competitive foods; perceptions that students...
The effect of hyperthermia on microcirculatory and metabolic parameters in s.c. DS-sarcomas different sizes the hind foot dorsum SD-rats was investigated. Hyperthermia carried out using a novel water-filtered, infrared-A radiation technique. Heating performed at rate 0·5°C/min until 44°C achieved tumour centre, which maintained for 60 min. Using multichannel laser Doppler flowmeter, red blood cell flux could be assessed continuously several sites within tissue simultaneously. Substantial...
This paper describes Project FIT, a collaboration between the public school system, local health systems, physicians, neighborhood associations, businesses, faith-based leaders, community agencies and university researchers to develop multi-faceted approach promote physical activity healthy eating toward general goal of preventing reducing childhood obesity among children in Grand Rapids, MI, USA.There are four overall components FIT: school, community, social marketing, staff wellness - all...
The effects of combined and simultaneously applied localised 43 degrees C hyperthermia (HT) an antivascular bacteriochlorophyll-serine-based photodynamic therapy (Bchl-ser-PDT) on tumour growth several microenvironmental parameters were examined. Rats bearing DS-sarcomas allocated to treatment groups: (i) sham-treatment (control), (ii) Bchl-ser-PDT (20 mg kg(-1) i.v.), (iii) HT, (iv) Bchl-ser-PDT+HT. light source used was infrared-A irradiator, which, by use appropriate filters, delivered...
Background. The Child Nutrition and WIC Reauthorization Act of 2004 mandated written school wellness policies. Little evidence exists to evaluate the impact such This study assessed quality (comprehensiveness topics addressed strength wording) policies agreement between district-level school-reported nutrition practices in 48 low-income Michigan districts participating School Advances Kids study. Method. Written policy was using Wellness Policy Evaluation Tool. were Environment Survey....
In selective internal radiation (SIR) therapy of hepatic metastases, tumor vasculature is preferentially embolized with high-energy beta-emitting yttrium-90-labeled microspheres. To enable accurate estimation the resultant absorbed doses to tissues, an intraoperative beta detection probe used scan liver surface. The validity response this Y-90 and its clinical application were assessed a phantom containing varying activities biopsy samples obtained from patients being treated SIR therapy. A...
The possibility of enhancing aminolaevulinic acid (ALA)-based photodynamic therapy (PDT) by simultaneous application localised hyperthermia (HT) was evaluated. Treatments rat DS-sarcomas included: (i) control, (ii) ALA administration (375 mg kg(-1), i.p.), no illumination, (iii) 'nonthermal' (iv) ALA-PDT: that is, administration, (v) HT, 43 degrees C, 60 min (vi) ALA-PDT+HT: with full spectrum irradiation resulting in ALA-PDT and HT. Tumour volume monitored for 90 days or until a target (3.5...
This study investigated long-term microenvironmental responses (oxygenation, perfusion, metabolic status, proliferation, vascular endothelial growth factor (VEGF) expression and vascularisation) to chronic hypoxia in experimental tumours. Experiments were performed using s.c.-implanted DS-sarcomas rats. In order induce more pronounced tumour hypoxia, one group of animals was housed a hypoxic atmosphere (8% O(2)) for the whole period (chronic hypoxia). A second acutely exposed inspiratory...
Perfusion and oxygenation of experimental tumours were studied during angiotensin II (AT II) administration whereby the rate continuous AT infusion was chosen to increase mean arterial blood pressure (MABP) by 50–70 mmHg. In subcutaneous DS- sarcomas red cell (RBC) flux assessed using laser Doppler technique tumour oxygen partial (pO2) measured polarographically O2-sensitive catheter needle electrodes. Changes in RBC with increasing MABP depended mainly on size. small tumours, decreased...
Abstract: In a population of 473 inpatients, profile nutritional status from obesity to marasmickwashiokor was observed. Thirty–two per cent the were overweight or obese (n = 153), forty–five normal weight 211), 8% at risk protein–energy malnutrition 39), and 15% 70) had grades marasmus marasmic–kwashiokor. The implications for improved support services hospitalised patients are discussed.
The present study was undertaken to exploit pathophysiological properties of solid tumours for a tumour-specific therapy. Experiments were carried out on DS-sarcomas implanted s.c. in the hind foot dorsum Sprague Dawley rats. Treatment strategies included tumour acidification, lactate accumulation and disturbance microcirculation by induced systemic hyperglycaemia/hyperlact-acidaemia (15–25/10 mmol/L; 60 min) as well localized hyperthermia (water-bath; 43°C, 30 min.). A special infusion...
Electrical bioimpedance spectroscopy is a fast and relatively easily applicable method for tissue characterization. In the frequency range up to 10 MHz, current conduction through mainly determined by structure, i.e. extra- intra-cellular compartments insulating cell membranes. Therefore, changes in fluid volumes are reflected impedance spectra. Investigations of tumours (DS sarcoma, implanted on hind foot dorsum rats) during treatment with localized hyperthermia (HT), photodynamic therapy...