A5031736405- Pancreatic and Hepatic Oncology Research
- Gallbladder and Bile Duct Disorders
- Gastric Cancer Management and Outcomes
- Cholangiocarcinoma and Gallbladder Cancer Studies
- NF-κB Signaling Pathways
- Plant Molecular Biology Research
- Pediatric Hepatobiliary Diseases and Treatments
- Pancreatitis Pathology and Treatment
- Neuroendocrine Tumor Research Advances
- Renal cell carcinoma treatment
- Flowering Plant Growth and Cultivation
- Gastrointestinal Tumor Research and Treatment
- Plant Reproductive Biology
- Plant Physiology and Cultivation Studies
- Angiogenesis and VEGF in Cancer
- Colorectal and Anal Carcinomas
- Cytokine Signaling Pathways and Interactions
- Gastrointestinal disorders and treatments
- Cell death mechanisms and regulation
- Lung Cancer Diagnosis and Treatment
- Hepatocellular Carcinoma Treatment and Prognosis
- Cancer, Hypoxia, and Metabolism
- Abdominal vascular conditions and treatments
- Metastasis and carcinoma case studies
- Soft tissue tumor case studies
Jikei University Kashiwa hospital
2016-2024
Jikei University School of Medicine
2011-2021
The Jikei University Hospital
2012-2018
Tottori University Hospital
2009-2012
Koshigaya Municipal Hospital
2012
Tottori University
1996-2009
The University of Texas MD Anderson Cancer Center
2002-2008
RIKEN
1993-2006
Molecular Oncology (United States)
2003
Niigata Cancer Center Hospital
1998-2000
Nuclear factor kappaB (NF-kappaB) and activator protein 1 (AP-1) transcription factors regulate many important biological pathological processes. Activation of NF-kappaB is regulated by the inducible phosphorylation inhibitor IkappaB kinase. In contrast, Fos, a key component AP-1, primarily transcriptionally serum responsive (SRFs) ternary complex (TCFs). Despite these different regulatory mechanisms, there an intriguing possibility that AP-1 may modulate each other, thus expanding scope two...
The Arabidopsis DEETIOLATED2 (DET2) gene has been cloned and shown to encode a protein that shares significant sequence identity with mammalian steroid 5 alpha-reductases. Loss of DET2 function causes many defects in development can be rescued by the application brassinolide; therefore, we propose encodes reductase acts at first step proposed biosynthetic pathway--in conversion campesterol campestanol. Here, used biochemical measurements biological assays determine precise defect det2...
Both pro- and antiapoptotic activities of NF-kappaB transcription factor have been observed; however, less is known about the mechanism by which induces apoptosis. To elucidate how regulates proapoptotic signaling, we performed functional analyses using wild-type, ikk1(-/-), ikk2(-/-), rela(-/-) murine fibroblasts, MDAPanc-28/Puro, MDAPanc-28/IkappaBalphaM, HCT116/p53(+/+) HCT116/p53(-/-) cells with investigational anticancer agent doxycycline as a superoxide inducer for generating apoptotic...
Abstract Purpose: Pancreatic adenocarcinoma is currently the fourth leading cause of cancer death in United States, and most pancreatic cancers develop locally advanced disease or metastasis at time diagnosis. The mechanisms by which it invades metastasizes are not known. Experimental Design: To identify genes involved metastasis, we analyzed gene expression profiles between highly metastatic Colo357L3.6pl parental Colo357FG cell lines using cDNA microarrays confirmed differential reverse...
Video-assisted thoracoscopic surgery (VATS) for clinical stage I non-small cell lung cancer (NSCLC) has been widely used as a less invasive surgical procedure, but the resection method is still controversial. We retrospectively compared outcomes of lobectomy, segmentectomy and wedge resection.A total 411 patients with NSCLC who underwent VATS (218 males 193 females, aged 69.3 years; 345 adenocarcinomas, 57 squamous carcinomas, 9 others) were investigated. The procedure was lobectomy in 289,...
Recently, the usefulness of intratumoral microvessel density (IMD) and expression several angiogenic factors as prognostic indicators have been demonstrated in human solid tumors.One hundred four patients with pancreatic ductal adenocarcinoma were examined retrospectively. The investigated clinicopathologic immunohistologic data included staining for vascular endothelial growth factor (VEGF), thymidine phosphorylase (TP), basic fibroblast (bFGF), CD34 (for calculating IMD), p53,...
The aim of this study was to evaluate the utility an image display system for augmented reality in hepatobiliary surgery under laparotomy.An overlay organs, vessels, or tumor obtained using a video see-through as developed at our institute. Registration between visceral organs and surface-rendering reconstructed by preoperative computed tomography (CT) carried out with optical location sensor. Using system, we performed laparotomy patient benign biliary stricture, gallbladder carcinoma,...
Abstract Background Both activated tumor-infiltrating lymphocytes (TILs) and immune-suppressive cells, such as regulatory T cells (Tregs), in the tumor microenvironment (TME) play an important role prognosis of patients with pancreatic ductal adenocarcinoma (PDAC). Methods The densities TILs, programmed death receptor 1 (PD-1) + forkhead box P3 (Foxp3) were analyzed by immunohistochemical staining. associations immunological status PDAC overall survival (OS) time disease-free (DFS)...
To understand the regulatory mechanisms of brassinosteroid (BR) biosynthesis in specific plant developmental processes, we first investigated accumulation profiles BRs and sterols xylem differentiation a Zinnia culture. The amounts many substances late C28 sterol biosynthetic pathway to campesterol (CR), such as episterol 24-methylenecholesterol, well those BR-specific from CR brassinolide (BL), were elevated close association with tracheary element differentiation. Among them,...
Abstract Background In pancreaticoduodenectomy ( PD ), early ligation of the inferior pancreaticoduodenal artery IPDA ) before efferent veins has been advocated to decrease blood loss by congestion pancreatic head be resected. this study, we herein report utility identification using an augmented reality AR )‐based navigation system NS ). Methods Seven nonconsecutive patients underwent ‐based . After paired‐point matching registration, reconstructed image obtained preoperative computed...
Patients with pancreatic ductal adenocarcinoma (PDA) typically succumb to mortality early, even following surgical resection. Therefore, prognostic factors associated early are required improve the survival of patients PDA Carbohydrate sulfotransferase 15 (CHST15) is responsible for biosynthesis sulfated chondroitin sulfate E (CS‑E), which serves a pivotal function in cancer progression by cleaving CD44. CHST15 and CD44 expression tissue were assessed as factor A total 36 consecutive...
We have reported the utility of an image display system using augmented reality (AR) technology in hepatobiliary surgery under laparotomy. Among several procedures, we herein report a novel short rigid scope and stereo-scope, both designed specifically for open abdominal navigation surgery, their clinical application pancreatic surgery.The 3D reconstructed images were obtained from preoperative computed tomography data. In our specialized operating room, after paired-point matching...