A5058886023- Helminth infection and control
- Cholinesterase and Neurodegenerative Diseases
- Insect Pest Control Strategies
- Mycotoxins in Agriculture and Food
- Computational Drug Discovery Methods
- Insect and Pesticide Research
- Traditional and Medicinal Uses of Annonaceae
- Cassava research and cyanide
- Pesticide Exposure and Toxicity
- Nematode management and characterization studies
- Botanical Research and Chemistry
- Phytochemistry Medicinal Plant Applications
- Medicinal Plants and Neuroprotection
- Parasites and Host Interactions
- Rabbits: Nutrition, Reproduction, Health
- Plant Toxicity and Pharmacological Properties
- Food Safety and Hygiene
- Piperaceae Chemical and Biological Studies
- Bee Products Chemical Analysis
- Ethnobotanical and Medicinal Plants Studies
- Ruminant Nutrition and Digestive Physiology
- Pineapple and bromelain studies
- Botanical Research and Applications
- Plant and fungal interactions
- Essential Oils and Antimicrobial Activity
Universidade Estadual de Feira de Santana
2015-2025
Hospital Ana Nery
2004-2012
Universidade Federal da Bahia
2003-2012
The enhancement of cholinergic functions via acetylcholinesterase (AChE) and butyrylcholinesterase (BuChE) inhibition is considered a valuable therapeutic strategy for the treatment Alzheimer's disease. This study aimed to evaluate in vitro effect ZINC390718, previously filtered using computational approaches, on both cholinesterases characterize, molecular dynamics (MD) simulation, possible binding mode this compound inside cholinesterase enzymes. cytotoxicity was also investigated primary...
The dual inhibition of human acetylcholinesterase (hAChE) and butyrylcholinesterase (hBuChE) plays an important role in Alzheimer's disease treatment. Thus, this study aims identify promising inhibitors against hAChE hBuChE by silico approaches (pharmacophore-based virtual screening molecular docking). Ten 3 D pharmacophore models for using default genetic parameters were built GALAHAD™ available on SYBYL-X 2.0. Validation steps carried out according to Energy (<100.0 kcal/mol), Pareto = 0,...
This study describes the in vitro anthelmintic activity of aqueous extracts (AE), ethyl acetate (EE), flavonoid fractions (FF) and saponin (SF) obtained from sisal waste (Agave sisalana) against gastrointestinal nematodes goats. The these was evaluated by performing inhibition egg hatch (EHA) larval migration (LMI) assays. EC(50) results EHA corresponded to 4.7, 0.1 0.05 mg/mL for EE, EA FF, respectively. SF fraction showed no ovicidal activity. percent efficacies that were observed LMI...
The species Marcetia taxifolia (A. St.-Hil.) DC., Melastomataceae, which is endemic of the rupestrian fields northeastern Brazil, contains a significant amount flavonoids. In this work, potential ethanolic extract M. as active principle in sunscreen photoprotection (UV-A and UV-B) formulation was investigated. Liquid Chromatography High Performance-Diode Array Detector quantification (quercetin), total flavonoid content, antioxidant activity through 2.2-diphenyl-1- picrylhydrazil method,...
The resistance of gastrointestinal nematodes (GINs) small ruminants to anthelmintics has required the investigation new alternatives. aim present study was evaluate in vivo anthelmintic activity an aqueous extract from sisal waste (Agave sisalana) (AESW) against GINs goats and observe animals for toxic effects. Thirty that were naturally infected with distributed into three groups: group I, treated daily doses AESW (1.7 g/kg) eight days; Group II, positive control, a single dose levamisole...
Abstract This study assessed the anthelmintic activity of plant-derived compounds against gastrointestinal nematodes goats using egg hatch and larval motility assays. The tested were saponins (digitonin aescin) their respective sapogenins (aglycones), hecogenin acetate flavonoids (catechin, hesperidin, isocordoin a mixture cordoin). Additionally, cytotoxicity active substances was analysed on Vero cell through 3-4,5-dimethylthiazol-2-yl,2,5diphenyltetrazolium bromide (MTT) propidium iodide...
Abstract Introduction Lauraceae alkaloids are a structurally diverse class of plant specialised secondary metabolites that play an important role in modern pharmacotherapy, being useful as well model compounds for the development synthetic analogues. However, characterisation is challenging due to low concentrations, complexity extracts, and long processes accurate structural determinations. Objective The use high‐performance thin layer chromatography coupled with desorption electrospray...
Rhipicephalus microplus is an important ectoparasite of cattle, causing considerable economical losses. Resistance to chemical acaricides has stimulated the search for new antiparasitic drugs, including natural products as eco-friendly alternative control. Flavonoids represent a class compounds with many biological activities, such enzyme inhibitors. Acetylcholinesterase essential tick survival that stands out target development acaricides. This work aimed predict this 3D structure by...
It was evaluated the anthelmintic activity of Agave sisalana (sisal) juice against gastrointestinal nematodes and its potential toxic effects in goats. In vitro tests showed more than 95% reduction larval counts genus Haemonchus spp. at concentrations between 86.5 146.3 mg.mL-1. vivo percent larvae fourth (L4) fifth (L5) stages Haemonchus, Oesophagostomum Trichostrongylus less groups GI GII, 80 90% group GIII. A. tested effective goats; however, efficacy reduced when administered to animals.
We investigated the in vitro acaricide activity of methanolic extract (ME) and alkaloid-rich fraction (AF) Prosopis juliflora on Rhipicephalus microplus correlated this effect with acetylcholinesterase (AChE) inhibition. The was evaluated using adult larval immersion tests. Also, we studied possible interaction mechanism major alkaloids present via molecular docking at active site R. AChE1 (RmAChE1). Higher reproductive inhibitory AF recorded, effective concentration (EC50) four times lower...
This study describes the effects of extracts and fractions Persea willdenovii leaves against goat gastrointestinal nematodes their cytotoxicity on Vero cells. The in vitro ovicidal larvicidal activities crude ethanolic, hexane, ethyl acetate (EAE), butanolic residual hydroethanolic were assessed through inhibition egg hatching larval motility assays. most active extract (EAE) was then fractionated by chromatography an open column containing silica gel, to furnish six (Fr1-Fr6), which also...
Abstract Sassafras albidum is an important tree species that occurs across North America. The presence of benzylisoquinoline and aporphine alkaloids has been previously described; however, the spatial distribution these compounds within S . other plants Lauraceae family still unclear. Mass spectrometry imaging become tool in analysis metabolites, uncovering contributions about functional role, biosynthetic pathway, accumulation plant. This work aimed to identify further present roots, twigs,...