A5071544497- Neuroscience and Neuropharmacology Research
- Mitochondrial Function and Pathology
- Tryptophan and brain disorders
- Infectious Encephalopathies and Encephalitis
- Parkinson's Disease Mechanisms and Treatments
- Stress Responses and Cortisol
- Neuroinflammation and Neurodegeneration Mechanisms
- Liver Disease Diagnosis and Treatment
- Diet and metabolism studies
- Neurological disorders and treatments
- Pharmacological Effects and Toxicity Studies
- Endoplasmic Reticulum Stress and Disease
- Phosphodiesterase function and regulation
- Gastrointestinal motility and disorders
- Metabolism and Genetic Disorders
- Drug Transport and Resistance Mechanisms
- Sphingolipid Metabolism and Signaling
Centro de Investigación Biomédica en Red de Salud Mental
2023-2025
Institut d'Investigacions Biomèdiques de Barcelona
2023-2025
Instituto de Salud Carlos III
2023-2025
Centro de Investigacion Principe Felipe
2019-2024
Consorci Institut D'Investigacions Biomediques August Pi I Sunyer
2023-2024
Consejo Superior de Investigaciones Científicas
2023-2024
Universitat de València
2024
Enhanced GABAergic neurotransmission contributes to impairment of motor coordination and gait cognitive function in different pathologies, including hyperammonemia hepatic encephalopathy. Neuroinflammation is a main contributor enhancement through increased activation pathways. For example, enhanced the TNFα–TNFR1-NF-κB-glutaminase-GAT3 pathway TNFα-TNFR1-S1PR2-CCL2-BDNF-TrkB cerebellum hyperammonemic rats enhances neurotransmission. This mediated by mechanisms affecting GABA synthesizing...
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Activated microglia and increased brain IL-1β play a main role in cognitive impairment much pathology. We studied the of neuroinflammation-induced following different types learning memory: novel object recognition (NOR), location (NOL), spatial learning, reference memory (RM), working (WM). All these processes are impaired hyperammonemic rats. assessed which restored by blocking IL-1 receptor vivo rats possible mechanisms involved. Blocking reversed microglial activation hippocampus,...
Hyperammonemia contributes to hepatic encephalopathy. In hyperammonemic rats, cognitive function is impaired by altered glutamatergic neurotransmission induced neuroinflammation. The underlying mechanisms remain unclear. Enhanced sphingosine-1-phosphate receptor 2 (S1PR2) activation in the cerebellum of rats we assessed if blocking S1PR2 reduced hippocampal neuroinflammation and reversed impairment signaling pathways were involved. was blocked with intracerebral JTE-013, evaluated. inducing...