Background: Coronavirus (Covid-19) infection represents a serious medical condition, often associated with cardiovascular complications, pulmonary hypertension (PH), and right ventricle dysfunction (RVD). The aim of this study is to show, by means transthoracic echocardiography (TTE), the presence an increased estimated systolic pressure in artery (esPAP) altered ventricular global longitudinal strain (RV-GLS) patients without history PH. Methods: In group 91 patients, aged under 55 years,...

The COVID-19 pandemic affected over 130 million individuals during more than one year. Due to the overload of health-care services, a great number people were treated as outpatients, many them subsequently developing post-acute syndrome. Our study was conducted on 150 subjects without history cardiovascular diseases, outpatients for mild/moderate form 4 12 weeks prior inclusion, and who diagnosed with attended cardiology evaluation transthoracic echocardiography (TTE) persisting symptoms. We...

(1) Background: Coronavirus infection (Covid-19) has emerged as a severe medical condition, associated with high pulmonary morbidity and often cardiovascular (CV) complications. This study aims to evidence the persistence of left ventricular (LV) systolic function (LV-SF) alterations diastolic dysfunction (DD) in COVID-19 patients without history diseases by transthoracic echocardiography (TTE). (2) Methods: 125 patients, aged under 55 years, hospitalized during first outbreak Covid-19 for...

(1) Background: Spontaneous pneumomediastinum (PM), pneumothorax (PT), and pneumopericardium (PP) were recently reported as rare complications in patients with severe COVID-19 pneumonia, our study aims to follow the evolution of these involvements 11 cases. The presumed pathophysiological mechanism is air leak due extensive diffuse alveolar damage followed by rupture. (2) Methods: We occurrence PM, PN, PP, subcutaneous emphysema (SE) 1648 hospitalized during second outbreak (October...

(1) Background: Although the infection with SARS-CoV-2 virus affects primarily lungs, it is well known that associated cardiovascular (CV) complications are important contributors to increased morbidity and mortality of COVID-19. Thus, in some situations, their diagnosis overlooked, during recovery, patients continue have symptoms enclosed now post-acute COVID-19 syndrome. (2) Methods: In 102 patients, under 55 years old, without a history CV diseases, all diagnosed syndrome, we assessed by...

Data on bacterial or fungal pathogens and their impact the mortality rates of Western Romanian COVID-19 patients are scarce. As a result, purpose this research was to determine prevalence co- superinfections in adults with COVID-19, hospitalized in-ward settings during second half pandemic, its distribution according sociodemographic clinical conditions. The unicentric retrospective observational study conducted 407 eligible patients. Expectorate sputum selected as sampling technique...

Renal cell carcinoma (RCC) remains incurable in advanced stages. Biomarkers have proven to be quite useful cancer therapeutics. Herein, we provide a comparative/integrative statistical analysis of seminal immunohistochemistry (IHC) findings for Wilms’ Tumor 1 antigen (WT1) and thymine dimers (TDs), emerging as atypical, yet promising, potential biomarkers RCCs. We assessed WT1/TD reactivity adult RCC tumor cells, microenvironment (TME), tumor-adjacent healthy renal tissue (HRT). WT1...

Oxidative stress (OS) plays a crucial role in placental pathogenesis and pregnancy-related complications. This review explores OS's impact on development function, focusing novel biomarkers for early detection of at-risk pregnancies emerging therapeutic strategies. We analyzed recent research OS pathophysiology, examining its sources, mechanisms, effects. While trophoblast invasion under low-oxygen conditions hypoxia-induced regulate physiological development, excessive can lead to...

Patients with severe COVID-19 experience high-stress levels and thus are at risk for developing acute stress disorder (ASD) and/or post-traumatic (PTSD). The present study aims to search correlations between psychiatric response coping strategies among individuals vs. remitted COVID-19. Ninety subjects were included in the study, divided into two samples by disease category. Our focus was analysing perceived intensity according NSESSS PCL-C-17 scales, COPE-60. High scores found 40% of...

(1) Background: Coronavirus disease 2019 (COVID-19) has a worse prognosis in individuals with obesity and metabolic syndrome (MS), who often develop cardiovascular complications that last throughout recovery. (2) Methods: This study aimed to analyze the evolution of diastolic dysfunction (DD), assessed by transthoracic echocardiography (TTE), 203 without and/or MS diagnosed post-COVID-19 syndrome. (3) Results: DD was frequently patients obesity, but also those (62.71% 56.6%, respectively),...

The Roma population accounts for over 3% (approximately 10 to 15 million) of Romania's permanent population, and it represents one Europe's most impoverished populations. Due poverty unemployment, minority may have diminished access healthcare preventive medicine. limited existing evidence suggests that the European group has been at a higher risk becoming ill dying during pandemic owing their lifestyle choices, socioeconomic circumstances, genetic pathophysiological traits. As result,...

Background and Objectives: In Coronavirus Disease 2019 (COVID-19), which is caused by the infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), clinical manifestations are primarily related to pulmonary system. Under 10% of cases also develop gastrointestinal events such as diarrhea, nausea, vomiting abdominal pain. Materials Methods: We conducted an observational, retrospective study in Infectious Diseases Clinic “Victor Babes” Hospital, Timis County, order assess...

The emergence of SARS-CoV2 has presented itself as a significant global health crisis. prevalence thrombotic events is known to be high in these patients, affecting various organ systems, sometimes leading cutaneous thrombosis, pulmonary embolism (PE), stroke, or coronary thrombosis. available evidence suggests that thromboembolism, hypercoagulability, and the excessive production proinflammatory cytokines play role development multiorgan failure. Methodology: This retrospective...

Growing research data suggests that the severity of COVID-19 is linked with higher levels inflammatory mediators, such as cytokines, chemokines, tumor necrosis factor, C-reactive protein, ferritin, and D-dimers. In addition, it was evident from existing SARS-CoV-2 infection differs according to independent risk factors race ethnicity. Some scarce evidence shows European Roma community likely be at an elevated illness death during pandemic due their lifestyle, social factors, economics....

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is known to cause a diverse spectrum of clinical manifestations ranging from mild, flu-like symptoms severe progressive pneumonia, distress with or without other extrapulmonary impairment. Hematological changes such as lymphopenia, neutrophilia, and anemia the disease progresses, are frequently found in COVID-19. Thrombocytopenia may be drug-induced can occur secondary sepsis, disseminated intravascular coagulation bone marrow...

(1) Background: While the COVID-19 pandemic has been persisting for almost 2 years, more and people are diagnosed with residual complications such as pulmonary hypertension (PH) right ventricular dysfunction (RVD). This study aims to evaluate course of PH borderline (BPH) at 3 6 months after acute infection investigate if there differences regarding its evolution between patients from first three waves this disease. (2) Methods: We analyzed, by transthoracic echocardiography (TTE), months'...

Renal cell carcinoma (RCC) is arguably the deadliest form of genitourinary malignancy and nowadays viewed as a heterogeneous series cancers, with same origin but fundamentally different metabolisms clinical behaviors. Immunohistochemistry (IHC) increasingly necessary for RCC subtyping definitive diagnosis. WT1 complex gene involved in carcinogenesis. To address reporting heterogeneity IHC standardization, we used recent N-terminus targeted monoclonal antibody (clone WT49) to evaluate protein...

The COVID-19 pandemic has determined an extraordinary challenge to healthcare systems worldwide. circumstances, characterized by elevated stress levels, prolonged working hours, new medical procedures, media attention, and high population expectations, have created extremely stressful situation for professionals. This period offered a unique opportunity examine the system responses of practitioners stress. research aimed identify work-related factors that significantly impact mental health...

Understanding and addressing post-radical prostatectomy (RP) erectile dysfunction (ED) is of paramount importance for clinicians. Cavernous nerve (CN) injury rat model studies have provided consistently promising experimental data regarding regaining function (EF) after damage-induced ED. However, these findings failed to translate efficiently into clinical practice, with post-RP ED therapeutic management remaining cumbersome enigmatic. This disparity highlights the need further...

Despite significant developments in renal cell carcinoma (RCC) detection and molecular pathology, mortality has been steadily rising. Advanced RCC remains an incurable disease. Better clinical management tools, i.e., biomarkers, have yet to emerge. Thymine-dimers (TDs) were traditionally considered photo-dependent pre-mutagenic lesions, occurring exclusively during ultra-violet light exposure. Non-oxidative, direct, preferential byproducts of DNA photochemical reactions, TDs, recently shown...

Posterior retroperitoneal laparoscopic adrenalectomy (PRLA) has emerged as a revolutionary minimally invasive technique for adrenal gland surgery, offering significant advantages over traditional open approaches. This narrative review aims to provide comprehensive update on PRLA, focusing its anatomical foundations, surgical technique, and clinical implications. We conducted an extensive of the current literature practices elucidate key aspects PRLA. The procedure leverages unique "backdoor"...