A5100773575- Agriculture, Soil, Plant Science
- Plant Pathogens and Fungal Diseases
- Fungal Biology and Applications
- Genetic factors in colorectal cancer
- Colorectal Cancer Treatments and Studies
- Mycotoxins in Agriculture and Food
- Food Quality and Safety Studies
- Pancreatic and Hepatic Oncology Research
- Wheat and Barley Genetics and Pathology
- Yeasts and Rust Fungi Studies
- Soybean genetics and cultivation
- Ubiquitin and proteasome pathways
- Crop Yield and Soil Fertility
- Endoplasmic Reticulum Stress and Disease
- Plant Disease Resistance and Genetics
- Fermentation and Sensory Analysis
- Agronomic Practices and Intercropping Systems
- Gastric Cancer Management and Outcomes
- Cancer, Hypoxia, and Metabolism
- Histone Deacetylase Inhibitors Research
- Powdery Mildew Fungal Diseases
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Ecology and Conservation Studies
- Autophagy in Disease and Therapy
- Agricultural Productivity and Crop Improvement
University of Michigan
2021-2025
Case Western Reserve University
2024
Indiana University – Purdue University Indianapolis
2021-2023
Indiana University School of Medicine
2021-2023
Ajou University
2018-2022
Gachon University
2020
Seoul National University
1996-2018
National Academy of Agricultural Science
2011-2015
Rural Development Administration
2013-2015
Gyeongsangnam-do Agricultural Research and Extension Services
2012-2014
Abstract Despite the connection of secretory cells, including goblet and enteroendocrine (EEC) to distinct mucus-containing colorectal cancer histologic subtypes, their role in progression has been underexplored. Here, our analysis The Cancer Genome Atlas (TCGA) single-cell RNA-sequencing data demonstrates that EEC progenitor cells are enriched BRAF-mutant patient tumors, cell lines, patient-derived organoids. In cancer, progenitors were blocked from differentiating further by DNA...
A new procedure for the dynamic kinetic resolution (DKR) of racemic alcohols into single enantiomers is described. This employs surfactant-treated subtilisin as an (S)-selective resolving catalyst and aminocyclopentadienylruthenium complex a racemizing catalyst. The DKR performed best in presence acyl donor such trifluoroethyl butyrate THF at room temperature. Eight simple secondary have been efficiently resolved with high optical purities good yields. subtilisin-based complementary...
Curcuma longa has been commonly used as a traditional remedy for variety of symptoms such inflammation, gastritis and gastric ulcer. When C. extract was administered per os to pylori-ligated rat stomachs, it reduced acid secretion protected against the formation mucosal lesions. We therefore tested whether inhibits ulcers by blocking H2 histamine receptor. Dimaprit, receptor agonist, induced intracellular cAMP production in U937 HL-60 promyelocytes. Pretreatment with significantly blocked...
Aspergillus is an important fungal genus used for the fermentation of Asian foods; this referred to as koji mold in Japan and China. A. oryzae, sojae, tamari are production miso shoyu Japan, but a comprehensive taxonomic study isolated from Meju, fermented soybean starting material traditional soy sauce paste Korea, has not been conducted. In study, various species were during mycobiota aspergilli identified based on phenotypic characteristics sequencing β-tubulin gene. Most strains found...
AKT/PKB is downregulated by the ubiquitin-proteasome system (UPS), which plays a key role in cell survival and tumor progression various types of cancer. The objective this study was to determine relationship between sequential ubiquitination lysine residues K284 K214 AKT R-HSPA5 (the arginylated form HSPA5), contribute autophagic/lysosomal degradation when impaired proteasomal activity induces cellular stress. Results show that proteasome inhibitors (PIs) increased ATE1 (arginyltransferase...
N-terminal arginylation in response to various stresses causes the ER chaperone BiP relocate and be degraded cytosol.
Pancreatic ductal adenocarcinoma (PDAC) is a drug resistant and lethal cancer. Identification of the genes that consistently show altered expression across patients' cohorts can expose effective therapeutic targets strategies. To identify such genes, we separately analyzed five human PDAC microarray datasets. We defined as 'consistent' if upregulated or downregulated in ≥ 4 datasets (adjusted P<0.05). The were subsequently queried additional datasets, including single-cell RNA-sequencing...
Colorectal cancer (CRC) stands as one of the primary causes death despite advancements in targeted therapies and chemotherapeutic methods. The oxaliplatin-based chemotherapy, such FOLFOX, remains limited by its toxic side effects development drug resistance. current studies demonstrate redox homeostasis an important therapeutic target cells through discovery glucose-6-phosphate dehydrogenase (G6PD) their major controller oxidative stress survival. In this study, we investigated potential...
Almost complete sequences of the 16S rRNA genes eight representative thermophilic streptomycetes were determined following isolation and cloning amplified genes. These aligned with those mesophilic streptomycetes, phylogenetic trees inferred by using four tree-making algorithms. The formed two distinct clades that supported high bootstrap values based on 1,000 resamplings. One clade encompassed Streptomyces macrosporus related species, second included thermodiastaticus allied taxa....
We report a high performance green color selective semitransparent inverted organic photodetectors (OPDs) with detectivity of 2.1 × 1012 cm Hz1/2/W at the wavelength 530 nm which has comparable to reported metal electrode based OPDs due low dark current density 3.8 10−10 A/cm2 −1 V. The transparent OPD showed transparency 26% and 60% in blue red regions, respectively. relatively transmittance region can be improved using appropriate selection active materials absorb only region.
ABSTRACT Macroautophagy is induced under various stresses to remove cytotoxic materials, including misfolded proteins and their aggregates. These protein cargoes are collected by specific autophagic receptors such as SQSTM1/p62 (sequestosome 1) delivered phagophores for lysosomal degradation. To date, little known about how cells sense react diverse inducing the activity of SQSTM1. Here, we show that peroxiredoxin-like redox sensor PARK7/DJ-1 modulates SQSTM1 targeting ubiquitin...
Discovery of small-molecule degraders that activate ubiquitin ligase–mediated ubiquitination and degradation targeted oncoproteins in cancer cells has been an elusive therapeutic strategy. Here, we report a cell–based drug screen the NCI drug-like compounds library enabled identification small ubiquitin-related modifier 1 (SUMO1). Structure-activity relationship studies analogs hit compound CPD1 led to lead HB007 with improved properties anticancer potency vitro vivo. A genome-scale...
In traditional systems of medicine, fruits, leaves, and stems Actinidia arguta (Sieb. et Zucc.) Planch. ex Miq. have been used to treat various inflammatory diseases. The present study determined the proximate composition, antioxidant, anti-inflammatory, hypoglycemic potential A. stem. Phenolic composition hot water extract its sub-fractions was by Folin-Ciocalteu's reagent method. vitro antioxidant activities samples were evaluated using 1,1-diphenyl-2-picrylhydrazyl (DPPH)...
Abstract Background Fibrosis plays an important role in both normal physiological and pathological phenomena as fibroblasts differentiate to myofibroblasts. The activation of is determined through interactions with the surrounding extracellular matrix (ECM). However, how this fibroblast-to-myofibroblast transition (FMT) regulated affected by elastin concentration a three-dimensional (3D) microenvironment has not been investigated. Methods We developed insoluble elastin-gradient 3D hydrogel...
Abstract Small molecule degraders of small ubiquitin‐related modifier 1 (SUMO1) induce SUMO1 degradation in colon cancer cells and inhibits the cell growth; however, it is unclear how leads to anticancer activity degraders. Genome‐wide CRISPR‐Cas9 knockout screen has identified StAR‐related lipid transfer domain containing 7 ( StarD7 ) as a critical gene for degrader's activity. Here, we show that both mRNA protein are overexpressed human its significantly reduces growth xenograft...
Effect of p-dopants in a p-doped hole transport layer inserted between indium tin oxide and donor α,α′-bis(2,2-dicyanovinyl)-quinquethiophene with deep highest occupied molecular orbital level is reported to remove the S-shape organic photovoltaics (OPV) cell. Among ReO3, MoO3, WO3, CuI, ReO3 possesses largest work function turns out be most efficient p-dopant current density-voltage curve OPV cells. The rest dopants could not get rid S-shape, even doping concentration 25 mol. %. difference...
Although TRAIL can directly induce cell death in some cancer cells, it appears that resistance exists many cancers. This study focuses on anti-cancer drugs for TRAIL-resistant head and neck (HNC) to provide further progress toward effective therapy. Results indicate HNC combined VPA treatment greatly reduced viability therefore induced death, relative with or alone. A caspase-dependent signaling pathway was demonstrated, also significantly decreased the expression of HDAC4. When we...
Chon-Sik Kang1, Young-Keun Cheong1, Kyeong-Hoon Kim1, Hag-Sin Jae-Han Son1, Kyong-Ho Kim1,Jong-Chul Park1, Dae-Ho Kim2, Jin-Kyeong Choi3, Jeong-Suk Bae4, Kee-Jong Choon-Ki Lee1,Kwang-Geun Bo-Kyoung Ki-Hun amd Chul-Soo Park5*. Korean J. Breed. Sci. 2015;47:330-8. https://doi.org/10.9787/KJBS.2015.47.3.330