Aurelio Orta‐Resendiz
A5086520001- HIV Research and Treatment
- Computational Drug Discovery Methods
- COVID-19 Clinical Research Studies
- Immune Cell Function and Interaction
- Bioinformatics and Genomic Networks
- Machine Learning in Bioinformatics
- HIV-related health complications and treatments
- SARS-CoV-2 and COVID-19 Research
- T-cell and B-cell Immunology
- Pneumocystis jirovecii pneumonia detection and treatment
- Microbial Metabolic Engineering and Bioproduction
- Herpesvirus Infections and Treatments
- HIV/AIDS drug development and treatment
- Vaccine Coverage and Hesitancy
- COVID-19 and Mental Health
- Genetics, Bioinformatics, and Biomedical Research
- Data-Driven Disease Surveillance
- CAR-T cell therapy research
- CRISPR and Genetic Engineering
- Kawasaki Disease and Coronary Complications
- Mosquito-borne diseases and control
- Protein Structure and Dynamics
- Long-Term Effects of COVID-19
- HIV/AIDS Research and Interventions
Université Paris Cité
2021-2023
Institut thématique Immunologie, inflammation, infectiologie et microbiologie
2023
Institut Pasteur
2020-2023
Sorbonne Paris Cité
2021
Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán
2020
Weatherford College
2020
Instituto Nacional de Enfermedades Respiratorias
2020
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) RNA generally becomes undetectable in upper airways after a few days or weeks postinfection. Here we used model of viral infection macaques to address whether SARS-CoV-2 persists the body and which mechanisms regulate its persistence. Replication-competent virus was detected bronchioalveolar lavage (BAL) macrophages beyond 6 months Viral propagation BAL occurred from cell inhibited by interferon-γ (IFN-γ). IFN-γ production...
Researchers around the world join forces to reconstruct molecular processes of virus-host interactions aiming combat cause ongoing pandemic.
We need to effectively combine the knowledge from surging literature with complex datasets propose mechanistic models of SARS-CoV-2 infection, improving data interpretation and predicting key targets intervention. Here, we describe a large-scale community effort build an open access, interoperable computable repository COVID-19 molecular mechanisms. The Disease Map (C19DMap) is graphical, interactive representation disease-relevant mechanisms linking many sources. Notably, it computational...
Abstract Background In resource-limited settings, multi-experienced HIV infected patients are often prescribed raltegravir for salvage therapy. Patients failing raltegravir-containing regimens require other drugs including integrase inhibitors. this context, real-life data about the resistance and cross-resistance pathways between inhibitors is limited. The aim of study was to investigate in a cohort Mexican regimen. Methods Twenty-five plasma samples from subjects antiretroviral which...
Abstract We describe a large-scale community effort to build an open-access, interoperable, and computable repository of COVID-19 molecular mechanisms - the Disease Map. discuss tools, platforms, guidelines necessary for distributed development its contents by multi-faceted biocurators, domain experts, bioinformaticians, computational biologists. highlight role relevant databases text mining approaches in enrichment validation curated mechanisms. Map their relevance pathophysiology...
ObjectivesThe aim of this study was to investigate the correlation between HIV-1 reservoir and levels immune activation in chronic patients under fully suppressive cART.MethodsWe quantified HIV proviral DNA 2-LTR circles loads from PBMCs, CD38+ Ki-67+ T-cells, IL-7 a cohort with more than 5 years ART at enrollment after 1 year.ResultsIn 29 participants median 8 (IQR, 6.9-9.4) cART we found higher CD8+ T-cells 1-year (P = .000). There non-statistically significant poor CD4+ T-cells. declined...
Here, we present a protocol for setting three spectral flow cytometry panels the characterization of human unconventional CD8+NKG2A/C+ T cells as well other and natural killer cell subsets. We describe steps standardizing, preparing, staining cells, experimental setup, final data analysis. This should be advantageous in various settings including immunophenotyping limited samples, immune function evaluation/monitoring, research oncology, autoimmune, infectious diseases.
Abstract Background The main cause of the persistently high levels immune activation in HIV positive patients undergoing suppressive chronic cART is still unknown. Previous findings have suggested a link between ongoing residual viral replication originating from reservoir and levels. However, there no clear evidence this assumption. aim study was to investigate correlation under fully cART. Methods We conducted prospective longitudinal cohort for more than 5 years without any documented...