A5064583474- PI3K/AKT/mTOR signaling in cancer
- Natural product bioactivities and synthesis
- Polyamine Metabolism and Applications
- Mast cells and histamine
- Sesquiterpenes and Asteraceae Studies
- Phytochemistry and Biological Activities
- Synthesis and biological activity
- Phytochemical compounds biological activities
- Natural Antidiabetic Agents Studies
- Microbial Natural Products and Biosynthesis
- CRISPR and Genetic Engineering
- Enzyme Production and Characterization
- Histone Deacetylase Inhibitors Research
- Phytochemicals and Medicinal Plants
- Bioactive Compounds and Antitumor Agents
- Drug-Induced Hepatotoxicity and Protection
- Melanoma and MAPK Pathways
- Phytochemistry and biological activities of Ficus species
- Livestock and Poultry Management
- Medicinal Plants and Neuroprotection
- Plant-derived Lignans Synthesis and Bioactivity
- Traditional and Medicinal Uses of Annonaceae
- Advanced Breast Cancer Therapies
- Pineapple and bromelain studies
- RNA and protein synthesis mechanisms
University of Kashmir
2018-2023
University of Veterinary and Animal Sciences
2023
University of Pretoria
2021
Indian Institute of Integrative Medicine
2011-2015
Royal Manchester Children's Hospital
2015
Council of Scientific and Industrial Research
2012-2014
Abstract Betulinic acid (BA) is a pentacyclic triterpenoid natural product reported to inhibit cell growth in variety of cancers. However, the further clinical development BA got hampered because poor solubility and pharmacological properties. Interestingly, this molecule offer several hotspots for structural modifications order address its associated issues. In our endeavor, we selected C-3 position desirable chemical modification improve cytotoxic potential prepared library different...
Cancer cells compared to their normal counterparts reveal different metabolic needs and this differential requirement of intermediates subsequent consequences require an elaborate understanding cancer cell metabolism increased energy production in these cells.Nevertheless differences have provided opportunities for developing novel therapeutic approaches the diagnosis treatment.In addition enhanced proliferative capacities tumor associated with aberrations many signal transduction pathways...
Proteases play a regulatory role in variety of pathologies including cancer, pancreatitis, thromboembolic disorders, viral infections and many others. One the possible strategies to combat these seems be use protease inhibitors. LC-pi I, II, III IV (Lavatera cashmerian-protease inhibitors) have been found vitro strongly inhibit trypsin, chymotrypsin elastase, proteases contributing tumour invasion metastasis, indicated anticancer effects. The purpose this study was check activity four...
In spite of the Betulinic acid (BA) being recognized as anticancerous source; its further use in clinical development is greatly hampered because poor pharmacokinetic properties. To circumvent these limitations, we synthesized a PI3K target based library 18 triazole derivatives and identified C-3 cyano analog betulinic (CBA) with significant cell death effects 5–7 fold higher potency than BA various cancers. Importantly, no such report available demonstrating involvement or structural...
Eukaryotic translation initiation factor 4E was recently shown to be a substrate of mTORC1, suggesting it may mediator mTORC1 signaling. Here, we present evidence that eIF4E phosphorylated at S209 interacts with TOS motif S6 Kinase1 (S6K1). We also show this interaction is sufficient overcome rapamycin sensitivity and dependence S6K1. Furthermore, eIF4E-TOS relieves S6K1 from auto-inhibition due carboxy terminal domain (CTD) primes for hydrophobic (HM) phosphorylation activation in...
Emodin (1,3,8-trihydroxy-6-methylanthraquinone) is a Chinese herbal anthraquinone that exhibits numerous biological activities, such as antitumor, antibacterial, antiinflammatory, and immunosuppressive. From an endophytic fungus, close relative of Polyporales sp., found in association with Rheum emodi, Wall. ex Meissn compound (Rz) was isolated characterizedby different spectroscopic techniques (1H-NMR, 13CNMR, 2D-NMR, HRMS). The displayed range cytotoxicities against human cancer cell lines...
The present study was undertaken to evaluate the effect of aqueous extract Podophyllum hexandrum against free radical-mediated damage and also explore its anticancer activity. exhibited significant activity in scavenging 1, 1-diphenyl-2-picryl-hydrazyl radicals, •OH DNA damage, lipid peroxide production rat liver microsomes. tested for reducing abilities. marker enzymes antioxidant defense homogenate assessed control carbon tetrachloride (CCl4)-treated animals. It observed that CCl4-induced...