A5044612691- Cancer Immunotherapy and Biomarkers
- Head and Neck Cancer Studies
- Colorectal and Anal Carcinomas
- Liver Disease Diagnosis and Treatment
- Advanced biosensing and bioanalysis techniques
- Diet, Metabolism, and Disease
- Mosquito-borne diseases and control
- Reliability and Maintenance Optimization
- Tracheal and airway disorders
- Pregnancy and preeclampsia studies
- Nutritional Studies and Diet
- Hepatocellular Carcinoma Treatment and Prognosis
- Mycobacterium research and diagnosis
- Statistical Methods in Clinical Trials
- Hemodynamic Monitoring and Therapy
- Data-Driven Disease Surveillance
- Renal function and acid-base balance
- Lung Cancer Diagnosis and Treatment
- Liver Disease and Transplantation
- Retinal and Macular Surgery
- Gestational Diabetes Research and Management
- Life Cycle Costing Analysis
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Prenatal Screening and Diagnostics
- Retinal Development and Disorders
Samsung Medical Center
2022-2025
Yonsei University
2014-2024
Kwangwoon University
2022-2024
Kangwon National University
2024
Academic Pediatric Association
2022
Korea Institute of Science and Technology
2021
Pusan National University
2011-2013
Seoul National University
2010
Gwangju Institute of Science and Technology
2008
Early detection and surgical treatment are essential to achieve a good outcome in gastric cancer (GC). Stage IV recurrent GC have poor prognosis. Therefore, new treatments for needed. We investigated the intestinal microbiome of patients attempted reverse immunosuppression immune cells through modulation metabolites. evaluated levels programmed death-ligand 1 (PD-L1) interleukin (IL)-10 peripheral blood immunocytes patients. Cancer tissues were obtained from who underwent resection GC,...
We investigated the modified triglycerides-glucose (TyG) indices and other markers for non-alcoholic fatty liver disease (NAFLD) in 225 participants aged 10-19 years, were divided into subgroups according to their NAFLD grade. performed logistic regression analysis calculated odds ratios (ORs) with 95% confidence intervals (CIs) of tertiles 2 3 each parameter, those tertile 1 as a reference. The area under receiver operating characteristic (ROC) curve was compare parameters identifying...
Abstract Zika virus is a highly infectious that part of the flavivirus group. Precise diagnosis significant issue for controlling global pandemic after COVID-19 era. For first time, we describe zika aptamer-based electrical biosensor detecting in human serum. The composed aptamer/MXene nanoparticle heterolayer on Au micro-gap electrode (AuMGE)/print circuit board (PCB) system. aptamer was designed to bind envelope protein by systematic evolution ligands exponential enrichment (SELEX)...
There are several different proposed data mining methods for the postmarketing surveillance of drug safety. Adverse events often classified into a hierarchical structure. Our objective was to compare performance these adverse with We generated datasets based on World Health Organization's Reaction Terminology (WHO-ART) evaluated signal detection, including frequentist such as reporting odds ratio (ROR), proportional (PRR), information component (IC), likelihood test-based method (LRT), and...
Abstract Purpose We aimed to evaluate the efficacy and safety of temperature‐controlled intraductal radiofrequency ablation (ID‐RFA) for advanced malignant hilar biliary obstruction (MHBO). Methods Patients were randomly assigned RFA group (ID‐RFA bilateral plastic stent [PS]) or non‐RFA (bilateral PS) at a 1:1 ratio. Exchange self‐expanding metal (SEMS) was performed after 3 months when premature PS occlusion occurred. Total event‐free patency, overall survival (OS), adverse events (AEs)...
The triglyceride glucose (TyG) index, derived from a combination of fasting and triglycerides, has been suggested as useful marker for insulin resistance (IR), in addition to modified TyG indices that combine obesity parameters. This study investigated the association utility IR prediction youth. Based on Korea National Health Nutritional Examination Survey, data 3728 youth aged 10–19 years were analyzed. Odds ratios (ORs) 95% confidence intervals (CIs) tertiles 2 3 each parameter calculated...
Investigations on the trends of prediabetes and non-alcoholic fatty liver disease (NAFLD) among children are scarce. We aimed to analyze NAFLD, as well their association, Korean adolescents from 2009 2018. This study investigated prevalence prediabetes, abdominal obesity 6327 aged 10-18 years according age, sex, body mass index (BMI) using a nationally representative survey. The increased 5.14%, 8.17%, 5.97% respectively, in 10.46%, 12.05%, 10.51% In age-specific analyses, an adverse trend...
Clinical implications of neoadjuvant immunotherapy in patients with locally advanced but resectable head and neck squamous cell carcinoma (HNSCC) remain largely unexplored.
ABSTRACT Background and Aim Existing hepatocellular carcinoma (HCC) prediction models for the general population without traditional risk factors chronic liver disease are limited. This study aimed to develop an HCC model individuals lacking these factors. Methods The total of 138 452 adult participants viral hepatitis or significant alcohol intake who underwent regular health checkup at a tertiary hospital in South Korea were followed up development HCC. Risk analyzed using Cox regression...
Introduction Recent post hoc analyses indicate that patients with normal or low body mass index (BMI) benefit from sodium-glucose cotransporter-2 (SGLT2) inhibitor use. We aimed to evaluate the effects of SGLT2 inhibitors on renal and patient outcomes in diabetes BMI. Research design methods This single-center retrospective cohort study included 5,842 adult type 2 BMI<23 kg/m 2016 2020. Patients were divided into control groups matched using propensity scores. The primary outcome was...
There is inconclusive evidence of the association between dietary sodium, potassium, and sodium-to-potassium ratio all-cause cardiovascular disease mortality. To investigate mortality risks. Data from 143,050 adult participants were analyzed prospective 10-year community-based cohort analysis. Dietary at baseline assessed by a food frequency questionnaire. In Cox proportional hazards regression models, their was estimated using hazard ratios 95% confidence intervals, predictive ability as...
Although previous studies have established that dietary fiber (DF) intake reduces the total cardiovascular disease (CVD) mortality in general populations, limited been conducted individuals with pre-existing chronic conditions, especially Asian countries. We aimed to investigate association of DF all-cause and CVD population subpopulation hypertension, diabetes, dyslipidemia. examined relationship between using Korean genome epidemiology study. Diet was assessed a food-frequency...
This study aimed to investigate the prevalence of carbon monoxide (CO) poisoning and provision hyperbaric oxygen therapy (HBOT) in South Korea.We used data from Korea Health Insurance Review Assessment service.In total, 44,361 patients with CO were identified across 10 years (2010-2019).The was found be 8.64/10,000 people, a gradual annual increment.The highest 11.01/10,000 individuals, among those aged 30-39 years.In 2010, HBOT claimed 15 hospitals, increased 30 hospitals 2019.A total 4,473...
Background: Thoracoscopic lobectomy for lung cancer is a complex procedure where endoscopic staplers play critical role in transecting the parenchyme, vasculature, and bronchus. This retrospective study was performed to investigate economic benefits of powered tissue-specific such as gripping surface technology (GST) vascular stapler (PVS) compared standard staplers.Methods: Two hundred seventy-five patients who received thoracoscopic between 2008 2016 were included. Group 1 (n = 117)...
The aims of the study were to develop and evaluate a machine learning model with which predict postnatal growth failure (PGF) among very low birth weight (VLBW) infants.Of 10425 VLBW infants registered in Korean Neonatal Network between 2013 2017, 7954 included. PGF was defined as decrease Z score >1.28 at discharge, compared that birth. Six metrics [area under receiver operating characteristic curve (AUROC), accuracy, precision, sensitivity, specificity, F1 score] obtained five time points...
We aimed to investigate the association between dietary zinc intake and total deaths, cancer, cardiovascular disease death. In this prospective, 10-year, community-based cohort analysis, data from 143,050 adult participants (aged 40 years older) were analyzed. Dietary at baseline was assessed using a food frequency questionnaire. Harrell’s C-index used determine optimal cut-off of with log-rank test. Using Cox proportional hazards regression models, all-cause, mortality estimated hazard...
Thyroid cancer (TC) prevalence has been rapidly increasing. While the relationship between thyroid hormones and lipids widely investigated, studies regarding dyslipidemia in patients with TC have scarce controversial. We aimed to investigate risk after diagnosis compared general population without TC.
A relationship between the axillary-lateral thoracic vessel juncture (ALTJ) dose and lymphedema rate has been reported in patients with breast cancer. The purpose of this study was to validate explore whether incorporation ALTJ dose-distribution parameters improves prediction model's accuracy.A total 1,449 women cancer who were treated multimodal therapies from two institutions analyzed. We categorized regional nodal irradiation (RNI) as limited RNI, which excluded level I/II, vs extensive...
Abstract Objective The purpose of this study was to evaluate the strategy screening for preeclampsia (PE) in first trimester based on maternal characteristics, and estimated placental volume (EPV). Methods A prospective cohort performed with 351 women enrolled, which 13 developed PE. This analyzed risk PE according ultrasonography findings placenta, serum markers. ultrasound exam pregnancy-associated plasma protein (PAPP-A) determined at 11+0 13+6 weeks alpha-fetoprotein (MSAFP), human...