A5075449812- Neuroscience and Neuropharmacology Research
- Ion channel regulation and function
- Nonlinear Dynamics and Pattern Formation
- Neural dynamics and brain function
- stochastic dynamics and bifurcation
- Neuropeptides and Animal Physiology
- Receptor Mechanisms and Signaling
- Epilepsy research and treatment
- Cerebral Palsy and Movement Disorders
- Biochemical Analysis and Sensing Techniques
- Hemispheric Asymmetry in Neuroscience
- Metabolism and Genetic Disorders
- Pharmacological Receptor Mechanisms and Effects
- EEG and Brain-Computer Interfaces
- Nicotinic Acetylcholine Receptors Study
- Cardiac electrophysiology and arrhythmias
- Photoreceptor and optogenetics research
- Vestibular and auditory disorders
- Advanced Neuroimaging Techniques and Applications
- Neonatal and fetal brain pathology
- Ion Channels and Receptors
- Transcranial Magnetic Stimulation Studies
- Hearing, Cochlea, Tinnitus, Genetics
- RNA regulation and disease
- Electron Spin Resonance Studies
University of California, San Francisco
2021-2025
McGill University
2019-2025
Technical University of Munich
2014
University of Alberta
2014
Munich Cluster for Systems Neurology
2014
Ludwig-Maximilians-Universität München
2012
Loss-of-function variants in the gene SCN2A, which encodes sodium channel NaV1.2, are strongly associated with autism spectrum disorder and intellectual disability. An estimated 20%–30% of children these also suffer from epilepsy, altered neuronal activity originating neocortex, a region where NaV1.2 channels expressed predominantly excitatory pyramidal cells. This is paradoxical, as loss cells would be expected to dampen neocortical rather than promote seizure. Here, we examined neurons...
Opioids regulate circuits associated with motivation and reward across the brain. Of opioid receptor types, delta receptors (DORs) appear to have a unique role in regulating activity of related without liability for abuse. In neocortex, DORs are expressed primarily interneurons, including parvalbumin- somatostatin-expressing interneurons that inhibit somatic dendritic compartments excitatory pyramidal cells, respectively. But how transmission from these key interneuron classes is unclear. We...
ABSTRACT Opioids regulate circuits associated with motivation and reward across the brain. Of opioid receptor types, delta receptors (DORs) appear to have a unique role in regulating activity of related without liability for abuse. In neocortex, DORs are expressed primarily interneurons, including parvalbumin- somatostatin-expressing interneurons that inhibit somatic dendritic compartments excitatory pyramidal cells, respectively. But how transmission from these key interneuron classes is...
Abstract Neuronal excitability in the vertebrate brain is governed by coordinated activity of both ligand- and voltage-gated ion channels. In cerebellum, spontaneous action potential (AP) firing inhibitory stellate cells (SCs) variable, typically operating within 5- to 30-Hz frequency range. AP shaped somatodendritic A-type K + channels effect GABAergic transmission. An added complication, however, that whole-cell recording from SCs induces a time-dependent sustained increase membrane making...
The limbic system is presumed to have a central role in cognitive performance, particular memory. purpose of this study was investigate the relationship between white matter microstructure and neuropsychological function temporal lobe epilepsy (TLE) patients using diffusion tensor imaging (DTI). Twenty-one adult TLE patients, including seven non-lesional (nlTLE) fourteen with unilateral mesial sclerosis (uTLE), were studied both DTI hippocampal T2 relaxometry. Correlations performed...
Cerebellar stellate cells (CSCs) are spontaneously active, tonically firing (5-30 Hz), inhibitory interneurons that synapse onto Purkinje cells. We previously analyzed the excitability properties of CSCs, focusing on four key features: type I excitability, non-monotonic first-spike latency, switching in responsiveness and runup (i.e., temporal increase during whole-cell configuration). In this study, we extend analysis by using configuration to show these neurons can also burst when treated...
Key points We show that NMDA receptors (NMDARs) elicit a long‐term increase in the firing rates of inhibitory stellate cells cerebellum NMDARs induce intrinsic plasticity through Ca 2+ ‐ and CaMKII‐dependent pathway drives shifts activation inactivation properties voltage‐gated Na + (Na v ) channels An identical signalling is triggered during whole‐cell recording which lowers action potential threshold by causing hyperpolarizing shift gating channels. Our findings open more general...
Event Abstract Back to Spatial Attention Influences Plasticity Induction in the Motor Cortex Marc Kamke1*, Alexander Ryan2, Martin Sale1, Megan Campbell1, Stephan Riek3, Timothy Carroll3 and Jason Mattingley4 1 The University of Queensland, Queensland Brain Institute, Australia 2 School Psychology, 3 Human Movement Studies, 4 , Institute It is widely accepted that alterations strength communication between neurons, or 'Hebbian' (synaptic) plasticity, plays a major role capacity adult brain...