A5032818897- Olfactory and Sensory Function Studies
- Alzheimer's disease research and treatments
- Advanced Chemical Sensor Technologies
- Salivary Gland Disorders and Functions
- Glaucoma and retinal disorders
- Neurological Disease Mechanisms and Treatments
- Biochemical Analysis and Sensing Techniques
- Neurological Disorders and Treatments
- Neurobiology and Insect Physiology Research
Daegu Gyeongbuk Institute of Science and Technology
2020-2024
Maastricht University
2024
Hyposmia in Alzheimer's disease (AD) is a typical early symptom according to numerous previous clinical studies. Although amyloid-β (Aβ), which one of the toxic factors upregulated AD, has been identified many studies, even peripheral areas olfactory system, pathology involving sensory neurons (OSNs) remains poorly understood.Here, we focused on and delved deeper into direct relationship between pathophysiological behavioral results using odorants. We also confirmed histologically...
Abstract Background Alzheimer’s disease (AD) therapy requires timely and accurate diagnosis for prompt drug intervention, emphasizing the need a more accessible biomarker screening test. Previous studies identified higher expression of oligomeric Aβ in AD patients, however, quantitative measurements nasal Aβ42 levels full continuum remain unknown. Method We collected discharge samples from 161 subjects who underwent neuropsychological battery tests amyloid‐PET were measured via enzyme‐linked...
Abstract Background The key in Alzheimer’s disease (AD) therapy is a timely and accurate diagnosis for prompt drug intervention. However, due to the high cost invasiveness of conventional biomarker analyses, including brain positron emission tomography (PET) imaging cerebrospinal fluid (CSF)‐based assays, easy accessibility these screening tests often hindered. There is, therefore, great need develop more accessible test using less invasive cost‐effective peripheral body biomarkers. Previous...
Abstract Background: Hyposmia in Alzheimer’s disease (AD) is a typical early symptom according to numerous previous clinical studies. Although the causes of damage have been proposed every olfactory system including epithelium, bulb and cortex, main AD- related hyposmia are largely unknown. Methods: We here focused on peripheral sensory neurons (OSNs) delved deeper into direct relationship between pathophysiological behavioral results using odorants. also histologically confirmed...
Abstract Background: Hyposmia in Alzheimer’s disease (AD) is a typical early symptom according to numerous previous clinical studies. Although amyloid-β (Aβ), which one of the toxic factors upregulated AD, has been identified many studies, even peripheral areas. The pathology involving olfactory sensory neurons (OSNs) remains poorly understood. Methods: Here, we focused on and delved deeper into direct relationship between pathophysiological behavioral results using odorants. We also...
Abstract Background: Hyposmia in Alzheimer’s disease (AD) is a typical early symptom according to numerous previous clinical studies. Although amyloid-β (Aβ), which one of the toxic factors upregulated AD, has been identified many studies, even peripheral areas. The pathology involving olfactory sensory neurons (OSNs) remains poorly understood. Methods: Here, we focused on and delved deeper into direct relationship between pathophysiological behavioral results using odorants. We also...
Abstract Background The key in Alzheimer’s disease (AD) therapy is a timely and accurate diagnosis for prompt drug intervention. However, due to the high cost invasiveness of conventional biomarker analyses, including brain positron emission tomography (PET) imaging cerebrospinal fluid (CSF)‐based assays, easy accessibility these screening tests often hindered. There is, therefore, great need develop more accessible test using less invasive cost‐effective peripheral body biomarkers. Previous...