A5000366716- Platelet Disorders and Treatments
- Protease and Inhibitor Mechanisms
- Antiplatelet Therapy and Cardiovascular Diseases
- Hyperglycemia and glycemic control in critically ill and hospitalized patients
- Oral and gingival health research
- Diabetes Management and Research
- Nutrition and Health in Aging
- Periodontal Regeneration and Treatments
- S100 Proteins and Annexins
- Blood donation and transfusion practices
- Blood transfusion and management
- Cell Adhesion Molecules Research
- Trauma, Hemostasis, Coagulopathy, Resuscitation
- Acute Myocardial Infarction Research
- Clinical Laboratory Practices and Quality Control
- Cerebrovascular and Carotid Artery Diseases
- Protein Kinase Regulation and GTPase Signaling
- Sepsis Diagnosis and Treatment
- Cytokine Signaling Pathways and Interactions
- Galectins and Cancer Biology
- Frailty in Older Adults
- Lipoproteins and Cardiovascular Health
- Reliability and Agreement in Measurement
- Erythrocyte Function and Pathophysiology
- Blood groups and transfusion
Wroclaw Medical University
2017-2025
The reasons for unfavorable changes in platelet concentrate (PC) quality during storage are not fully understood yet. We aimed to evaluate whether leukocytes and matrix metalloproteinases (MMPs) lead a decrease the of PCs examine MMP inhibition will slow down platelets’ aging. Nine were divided into three parts: (1) leukocyte-depleted (F) PCs, (2) with no additional procedures (NF), (3) addition an inhibitor—doxycycline (D). Each PC was stored 144 h, sample testing separated from each part...
Sepsis is one of the most common causes hospitalization and it characterized by a high mortality rate in spite great progress diagnosis treatment achieved recent years. Early sepsis important elements effective treatment. The clinical symptoms are not specific biomarkers considered to be useful tools diagnostics.The aim our study was evaluate diagnostic value sCD163 as marker comparison with procalcitonin neopterin ICU patients.Concentrations PCT, NPT were measured 52 serum samples collected...
The present study investigated whether Rho-associated protein kinase (RhoA/ROCK) signaling pathway inhibitor simvastatin inhibits matrix metalloproteinase 2 (MMP-2) activity in a rat ischemia-reperfusion injury (I/Ri) model by inhibiting the RhoA/ROCK and reducing MMP-2 mRNA levels. Isolated hearts were subjected to aerobic perfusion or I/Ri control. effect of was assessed I/Ri. We determined cardiac mechanical function, content RhoA, phosphorylated myosin light chain subunit 1...
20 patients undergoing routine carotid endarterectomy and 40 healthy volunteers were enrolled in this study. MMPs activity OPG FN concentrations measured atherosclerotic plaques nonchanged contiguous tissue after homogenization as well plasma from reference group. The of was evaluated by gelatin zymography, the concentration assessed ELISA.OPG MMP-9 showed differences between plaque tissue; higher adjacent (P=0.0009), whereas (proMMP-9 P=0.0003; P < 0.0001). both (OPG 0.001; proMMP-2...
Many studies have proven the involvement of RhoA/ROCK pathway in autoimmune and cardiovascular diseases beneficial effects its downregulation. Here, we examined whether effect simvastatin on experimental myocarditis (EAM) may be through targeting Ras homolog family member A/Rho-associated coiled-coil containing kinases (RhoA/ROCK) previously shown downregulation metalloproteinase 9 (MMP-9) could associated with MLC phosphorylation. Two doses were administered to rats by gastric gavage for 3...
Polyphenols have antioxidant and anti-inflammatory properties maintain the immune system in balance; therefore, aim of study was to investigate effect polyphenols present pomegranate peel extract on spleens rats with metabolic syndrome. The objects were adult male Zucker Diabetic Fatty (ZDF-Leprfa/Crl, fa/fa) rats. divided into a control group (MetS) consisting syndrome four groups (MetS + 100 mg MetS 200 mg) or healthy animals (H H receiving polyphenol at dose mg/kg, respectively....
Strokes and their complications are major clinical social problems. Stroke diagnosis is limited to imaging evaluation – mainly by computed tomography (CT), which particularly low sensitive early ischemic stroke. Due diagnostic problems, there many studies conducted find a laboratory marker of stroke, can play similar role troponins in the acute coronary syndrome. The aim this article review scientific research usefulness potential stroke markers was assessed. Among analyzed parameters are:...
Introduction: Point of care testing (POCT) are tests carried out near to the patient, outside laboratory. There is a continuing increase interest in POCT, however issue quality those rises concerns. Glucose concentration measurements using glucometers, which makes analyzers POCT tool. All devices laboratory should be included internal control system according ISO 22870, so it necessary glucometers as well.<br>Aim: To perform tools University Hospital Wroclaw, evaluate correct use...
Introduction: Diagnostic process may be divided into three phases: preanalytical, analytical and postanalytical. Errors with potential impact on the patient’s treatment can made at each phase, however, most of them are preanalytical errors. Therefore, ongoing assessment these errors is extremely important. Aim: Analysis in medical diagnostic laboratories. Materials methods: Data collected for two years (January 2015 – December 2016) were obtained from Wroclaw laboratories: one located a...
Background.Platelets play a fundamental role in myocardial infarction and the pathogenesis of ischemia/ reoxygenation (I/R) injuries.They contain matrix metalloproteinases (MMPs) that are involved arterial thrombosis.The MMP inhibitor doxycycline has been shown to exert protective effects I/R injuries involving various organs mechanisms.Objectives.To explore influence on platelet activation MMP-2 activity during I/R. Materials methods.Platelets isolated from blood healthy human volunteers...