A5064857129- Vascular Malformations Diagnosis and Treatment
- Intracranial Aneurysms: Treatment and Complications
- Meningioma and schwannoma management
- Thyroid Disorders and Treatments
- Cerebrospinal fluid and hydrocephalus
- Cardiac Arrhythmias and Treatments
- Growth Hormone and Insulin-like Growth Factors
- Atrial Fibrillation Management and Outcomes
- Neurofibromatosis and Schwannoma Cases
- Cardiac pacing and defibrillation studies
- Traumatic Brain Injury and Neurovascular Disturbances
- Moyamoya disease diagnosis and treatment
- Neurosurgical Procedures and Complications
- Cerebral Venous Sinus Thrombosis
- Neuropeptides and Animal Physiology
- Head and Neck Surgical Oncology
- Hypothalamic control of reproductive hormones
- Glioma Diagnosis and Treatment
- Cerebrovascular and Carotid Artery Diseases
- DNA Repair Mechanisms
- Cardiac electrophysiology and arrhythmias
- Epilepsy research and treatment
- Thyroid Cancer Diagnosis and Treatment
- Aortic Disease and Treatment Approaches
- Ion channel regulation and function
Fujita Health University
2015-2025
Fukuoka University
2024-2025
Fujita Health University Okazaki Medical Center
2021-2024
New Tokyo Hospital
2024
Fujita Health University Hospital
2014-2022
Fujita Health University Bantane Hospital
2015
Yokohama Municipal Minato Red Cross Hospital
2005
Red Cross Hospital
2003
University of the Ryukyus
1999-2000
Shiga University of Medical Science
1997-1998
Background Thromboembolic complications (TECs) are frequent during the endovascular treatment of unruptured aneurysms. To prevent TECs, dual antiplatelet therapy using aspirin and clopidogrel is recommended for perioperative period. In patients with a poor response, risk factor TECs. our study assessed stratified use prasugrel. Methods Patients who underwent cerebral aneurysms from April 2017 to August 2019 were enrolled in this clinical given premedication 2 weeks prior procedure. P2Y12...
Knowledge of the location tumor-feeding arteries is necessary for safe surgery intracranial meningiomas. Hence, this retrospective study aimed to comprehensively analyze distribution arteries. Patients who underwent meningioma at our institution between 2015 and 2023 were included in study. The tumor attachment sites evaluated based on results preoperative examinations. classified as non-skull bases (convexity, parasagittal, falx) or skull (anterior base, sphenoid ridge, sphenopetroclival,...
It is important to know whether a patient with Graves' disease will get into remission or not during antithyroid drug (ATD) treatment. Thyrotropin (TSH) receptor antibodies (TRAb) cause disease. Thyroid-stimulating antibody (TSAb) and TSH-binding inhibitor immunoglobulin (TBII) have been measured as TRAb diagnose follow patients. Smooth decreases of TSAb TBII ATD treatment predict the hyperthyroidism. We followed serial changes in 58 patients before, during, after treatment; was stimulator...
Resistance to temozolomide and intratumoral heterogeneity contribute the poor prognosis of glioma. The mechanisms resistance can vary within a heterogeneous tumor. Temozolomide adds methyl group DNA. primary cytotoxic lesion, O6-methylguanine, mispairs with thymine, leading futile DNA mismatch repair cycle, formation double-strand breaks, eventual cell death when O6-methylguanine methyltransferase (MGMT) is absent. N7-methylguanine N3-methyladenine are repaired by base excision (BER). study...
There are two types of TSH receptor antibodies (TRAb); thyroid stimulating antibody (TSAb) and TSH-stimulation blocking (TSBAb). TSAb causes Graves' hyperthyroidism. TSBAb hypothyroidism. Both block TSH-binding to cells as (TRAb). TSBAb-positive patients with hypothyroidism hyperthyroidism may have both TSAb. We studied in 43 55 untreated TSBAb-activities were expressed percentage inhibition bovine (b) TSH-stimulated cAMP production by test IgG. Two formulas used calculate TSBAb-activities;...
Three-dimensional visualization of cardiac activation has become important for providing further insights into the pathophysiological mechanisms arrhythmias and to increase efficacy catheter ablation. The noncontact mapping system enables a single-beat analysis reconstructed geometry chamber. In 8 patients with various kinds (3 atrial flutter, 2 right ventricular outflow tract tachycardia, 1 idiopathic left atrioventricular nodal reentrant tachycardia concealed Wolff-Perkinson-White...
Temozolomide (TMZ) induces prolonged arrest of human glioma cells in the G2/M phase and inhibition G2 checkpoint intensifies effect TMZ. These findings suggest that is linked to DNA repair mechanisms.To clarify mechanism TMZ resistance, we established TMZ-resistant (TR) clones by serial treatment U87MG with We evaluated TMZ-induced cell cycle various inhibitors.We observed longer exposure (over 6 months) enriched proportion TR underwent only minimal following compared short (4 Expression...
Cyclic adenosine monophosphate (cAMP) production during a 5-hour incubation using porcine thyroid cells (PTC) was stimulated significantly more by polyethylene glycol (PEG) 22.5% precipitated fractions (ppt frs) than PEG 12.5% ppt frs from almost all Graves' sera. However, the thyrotropin (TSH) binding inhibition (TBI) activities of and membranes were similar, did not change in incubation. When fr serum normal human (NHS) coincubated, cAMP also as much serum. purified stimulating antibody...
<h3>ABSTRACT</h3> <h3>BACKGROUND AND PURPOSE:</h3> Tumor embolization through the meningohypophyseal trunk and inferolateral is known to be effective in skull-based tumors; however, microcatheter cannulation into these arteries difficult, number of cases that can safely embolized limited. In this study, we present a novel procedure for using distal balloon protection technique detail its clinical efficacy complication risks. We developed allow safe patients who cannot adequately cannulated...
// Shunsuke Nakae 1 , Takema Kato 2 Kazuhiro Murayama 3 Hikaru Sasaki 4 Masato Abe 5 Masanobu Kumon Tadashi Kumai Kei Yamashiro Joji Inamasu Mitsuhiro Hasegawa Hiroki Kurahashi and Yuichi Hirose Department of Neurosurgery, Fujita Health University, Toyoake, Japan Division Molecular Genetics, Institute for Comprehensive Medical Science, Radiology, Keio Tokyo, Pathology, Correspondence to: Hirose, email: Keywords : IDH mutant gliomas, radiological classification recurrence, Intracranial remote...
The increase in the detection of unruptured cerebral aneurysms has led to management dilemma. Prediction risk based on size aneurysm is not always accurate. There no objective way predicting rupture so far. Computational fluid dynamics (CFDs) was proposed as a tool identify risk.To know correlation CFD findings with intraoperative microscopic and relevance prediction intracranial aneurysms.A prospective study involving nine cases over period 6 months an initial analysis.Both males females...
Thyroid stimulation blocking antibodies (TSBAb) inhibit TSH action and may have a role in the pathogenesis of hypothyroidism. In order to study relationship between stimulating activities we examined biologically active fragments TSBAb-IgG molecules after papain digestion.Both thyroid (TS) activity (cAMP production cells) binding inhibitory (TBI) (determined by receptor assay) sera from patients with primary hypothyroidism were digestion papain-Sepharose presence cysteine. The digested IgG...
The fenestration of the cerebral arteries is infrequent anomaly mostly occurring in posterior communicating artery, vertebral basilar and middle artery.[1] We report a case unilateral A1 associated saccular aneurysm, focusing on its features surgical treatment.