A5101461169- Effects and risks of endocrine disrupting chemicals
- Pesticide Residue Analysis and Safety
- Drug Transport and Resistance Mechanisms
- Agricultural safety and regulations
- Pesticide Exposure and Toxicity
- Pharmacological Effects and Toxicity Studies
- Pesticide and Herbicide Environmental Studies
- RNA Interference and Gene Delivery
- Contact Dermatitis and Allergies
- Advanced biosensing and bioanalysis techniques
- Insect and Pesticide Research
- Carcinogens and Genotoxicity Assessment
- Acute Lymphoblastic Leukemia research
- Pregnancy and Medication Impact
- Pharmacogenetics and Drug Metabolism
- Risk and Safety Analysis
- Folate and B Vitamins Research
- Glycosylation and Glycoproteins Research
- Toxin Mechanisms and Immunotoxins
- Nanoparticles: synthesis and applications
- Neonatal Respiratory Health Research
- Polymer Surface Interaction Studies
- Force Microscopy Techniques and Applications
- Trace Elements in Health
- Health, Environment, Cognitive Aging
Federal Institute for Risk Assessment
2016-2025
d-fine (Germany)
2023
Wageningen University & Research
2023
Benaki Phytopathological Institute
2018
Environmental Protection Agency
2018
Durham University
2018
Pension Fund for Care and Well-Being
2018
European Commission
2015
Leipzig University
2003-2008
Philipps University of Marburg
2006
This guidance on the assessment of dermal absorption has been developed to assist notifiers, users test facilities and Member State authorities critical aspects related setting values be used in risk assessments active substances Plant Protection Products (PPPs).It is based 'scientific opinion science behind revision document absorption' issued 2011 by EFSA Panel their Residues (PPR).The refers PPR many instances.In addition, first version this guidance, 2012 Panel, revised 2017 basis new...
Diverse polycationic polymers have been used as nonviral transfection agents. Here we report the ability of colloidal silica particles with covalently attached cationic surface modifications to transfect plasmid DNA in vitro and make an attempt describe structure resulting complexes. In analogy terms lipoplex polyplex, propose nanoparticle−DNA complexes by term "nanoplex". Three batches, Si10E, Si100E, Si26H, sized between 10 100 nm ζ potentials ranging from +7 +31 mV at pH 7.4 were...
Considering emerging and newly identified health risksOn request of the European Commission, independent Scientific Committee on Emerging Newly Identified Health Risks (SCENIHR) was requested to assess whether use nanosilver, in particular medical care or consumer products, could result additional risks compared more traditional uses silver nanosilver control bacterial growth resistance micro-organisms.The full text SCE-NIHR Opinion is freely accessible [1].This Comment looks at several...
A retrospective chronic cumulative risk assessment of dietary exposure to pesticide residues, supported by an uncertainty analysis based on expert knowledge elicitation, was conducted for two effects the thyroid, hypothyroidism and parafollicular cell (C-cell) hypertrophy, hyperplasia neoplasia. The pesticides considered in this were identified characterised scientific report establishment groups their thyroid. Cumulative assessments through probabilistic modelling EFSA Dutch National...
A retrospective acute cumulative risk assessment of dietary exposure to pesticide residues, supported by an uncertainty analysis based on expert knowledge elicitation, was conducted for two effects the nervous system: brain and/or erythrocyte acetylcholinesterase inhibition, and functional alterations motor division. The pesticides considered in this were identified characterised scientific report establishment groups their system. Cumulative assessments through probabilistic modelling EFSA...
With the increased production and widespread commercial use of silver nanoparticles (AgNPs), human environmental exposures to are inevitably increasing. In particular, persons manufacturing handling nanoparticle containing products at risk exposure, potentially resulting in health hazards. While dusts, consisting micro-sized particles soluble compounds have established occupational exposure limits (OELs), exhibit different physicochemical properties from bulk materials. Therefore, we...
The future of risk assessment cannot neglect to consider the vast literature produced through application new approach methodologies (NAMs). This, however, constitutes a challenge for assessor, as availability data in this context is huge and heterogeneous both methods applied standardisation quality results. integration results generated from NAMs hence only feasible under some degree automation workflow, specifically searching, extracting integrating such "AOP-like" knowledge networks (AOP...
Consumers are exposed to multiple residues of different pesticides via the diet. Therefore, EU legislation for requires evaluation single active substances as well consideration combination effects. Hence analysis combined effects in a broad dose range represents key challenge current experimental and regulatory toxicology. Here we report evidence additive (tri)azole fungicides, widely used group antifungal agents, human placental cell line Jeg-3. In addition triazoles cyproconazole,...
Abstract For endocrine disrupting chemicals (EDC) the existence of “safe exposure levels”, that is levels do not present an appreciable risk to human health most controversially discussed, as health-based reference values. Concerns have been especially raised EDCs might possess a threshold level such no can be considered safe. To explore whether or identified, we performed screening exercise on 14 pesticidal and biocidal active substances previously identified in European Union. The...
In light of the broad spectrum products containing nanosilver, harmfulness nanosilver to human health and environment was intensively discussed at a conference held in February 2012 BfR. The agenda covered aspects analytics materials, exposure toxicology as well effects on microorganisms environment. discussion recovered major gaps related commonly agreed guidelines for sample preparation central analytical techniques. particular, characterization nanoparticles complex matrices regarded...
In Europe, the data requirements for hazard and exposure characterisation of chemicals are defined according to REACH regulation its guidance on information chemical safety assessment (Regulation (EC) No 1907/2006 European Parliament Council 18 December 2006 concerning Registration, Evaluation, Authorisation Restriction Chemicals (REACH), documents; available at: http://eur-lex.europa.eu/LexUriServ/LexUriServ.do?uri=OJ:L:2006:396:0001:0849:EN:PDF ;...
Evaluation of data relevance, reliability and contribution to uncertainty is crucial in regulatory health risk assessment if robust conclusions are be drawn. Whether a specific study used as key study, additional information or not accepted depends part on the criteria according which its relevance judged. In addition GLP-compliant studies following OECD Test Guidelines, from peer-reviewed scientific literature have evaluated pesticide active substances. Publications should taken into...